Corticosteroids for Post-Extubation Dysphagia
NCT06670521
Recruiting
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal edema. Study was leveraged using the existing R01 grant infrastructure COMIRB # 21-3873, study design, and research methods. Patients for the study proposed will have already been enrolled in the R01 longitudinal cohort study. The sites to perform this study include Colo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Dysphagia, Laryngeal Edema
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Gonadal Tissue Cryopreservation for Fertility Preservation in Children with a Disorder of Sex Development
NCT06692049
Recruiting
The purpose of this study is to offer gonadal tissue freezing and storage to children who are diagnosed with a disorder of sex development (DSD), who are at increased risk of infertility and certain malignancies (cancer). This study involves the storage of gonadal tissue that is being removed for medical reasons (e.g. prevention of cancer development). It includes the processing and freezing of this gonadal tissue, hopefully for potential future use. The tissue will then be stored long-term unti... Read More
Gender:
ALL
Ages:
30 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: DSD, 46,XY, DSD, Ovotesticular, DSD, Sex Chromosome, Disorders of Sex Development, Disorder of Sex Development, 46,XY, Disorder of Sex Development, 46,Xy, Cbx2-Related
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Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
NCT06693622
Recruiting
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer. The plan is to use this information to modify screening practices in the United States with the goal to decrease the number of people who die from esophageal cancer.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
11/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Gastro Esophageal Reflux Disease, Barrett Esophagus
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Endovascular Exclusion of Thoracoabdominal And/or Paravisceral Abdominal Aortic Aneurysm
NCT00483249
Recruiting
This is a study to assess the safety and effectiveness of endovascular treatment of thoracoabdominal (TAAA) and paravisceral abdominal (PVAAA) aortic aneurysms. The investigational operation involves placing a stent-graft over the aortic aneurysm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Division of Vascular Surgery, SFVAMC, San Francisco, California +1 locations
Conditions: Thoracoabdominal Aortic Aneurysm, Paravisceral Abdominal Aortic Aneurysm
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Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183
Recruiting
Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.
Gender:
ALL
Ages:
All
Trial Updated:
11/13/2024
Locations: Clinical Trial Site, Aurora, Colorado +137 locations
Conditions: Atypical Hemolytic-Uremic Syndrome
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Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
NCT02323581
Recruiting
Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch aneurysms) in patients at high risk for open surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: New York Presbyterian Hospital, New York, New York +1 locations
Conditions: Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic, Aortic Dissection, Thoracoabdominal
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Deployment-Related Lung Disease Research Database and Biorepository
NCT03035097
Recruiting
The purpose of this research study is to establish a research database and biorepository for patients at National Jewish Health (NJH) who served in Operation Iraqi Freedom (OIF) or Operation Enduring Freedom (OEF). This study will also include civilian contractors who worked as part of these military operations in Iraq or Afghanistan. The biorepository would store blood samples obtained from these patients during a clinic visit. The research database would store prospectively and retrospectively... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: National Jewish Health, Denver, Colorado
Conditions: Bronchiolitis
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Families of Youth with Developmental Disabilities: a Theory-Based Intervention
NCT03495440
Recruiting
This study is designed to evaluate a preventive intervention program designed to support families (parents and typically developing adolescent siblings) that include a child with an intellectual and/or developmental disability. Participant families will be randomly assigned to either the treatment condition, in which they will receive psychoeducation and communication coaching over a four-week period, or the control condition, in which they will receive self-study materials. All subjects will pa... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/13/2024
Locations: Wm. J. Shaw Center for Children and Families, Fort Wayne, Indiana +1 locations
Conditions: Family Conflict, Marital Conflict, Communication
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Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
NCT04094090
Recruiting
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
11/13/2024
Locations: Goodman Eye Center, San Francisco, California
Conditions: Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
NCT04787042
Recruiting
This is a multiphase, multicenter study, which includes a Phase 1a open-label, dose escalation monotherapy study of ST-067 given as an SC injection with or without obinutuzumab \[Gazyva®\] pre-treatment, by IV infusion, and in combination with pembrolizumab. A Phase 2 monotherapy arm is also planned; the exact design of the Phase 2 study elements with respect to formulation and pre-treatment will be determined after completion of the Phase 1 study portion of the trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: HonorHealth Research Institute, Scottsdale, Arizona +5 locations
Conditions: Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma, Triple-negative Breast Cancer, Non Small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Carcinoma, MSI-High
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The Effect of Celecoxib on Neuroinflammation in MDD
NCT04814355
Recruiting
Major depressive disorder (MDD) affects an estimated 350 million people worldwide and is a leading contributor to global disease burden. Commonly used monoamine reuptake-inhibiting treatments for depression are suboptimal, resulting in only 30% of patients achieving remission. This may be because monoamine dysfunction is not the primary pathophysiology in all MDD patients. One avenue for the development of novel MDD treatments is through anti-inflammatory drugs; MDD is linked to a pro-inflammato... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2024
Locations: Psychiatry Department at Stony Brook University, Stony Brook, New York
Conditions: Major Depressive Disorder, Neuroinflammation
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The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
NCT04980794
Recruiting
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
Gender:
ALL
Ages:
4 years and above
Trial Updated:
11/13/2024
Locations: Fort Wayne Center for Children and Families, Fort Wayne, Indiana +2 locations
Conditions: Mental Health, Conflict
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