Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis
NCT05975983
Recruiting
The goal of this clinical trial is to learn about INS018_055 in adults with Idiopathic Pulmonary Fibrosis (IPF). The primary objective is to evaluate the safety and tolerability of INS018_055 orally administered for up to 12 weeks in adult subjects with IPF compared to placebo.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/25/2024
Locations: Keck School of Medicine of USC, Los Angeles, California +8 locations
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
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Cytomegalovirus (CMV) Transmission and Immune Tracking (TransmIT) Study
NCT06522880
Recruiting
The goal of STAGE I of the CMV TransmIT Study is to determine the prevalence of CMV shedding in children up to and including 36 months of age in large group childcare centers and in staff who regularly work at the center. Participants will complete a health survey and provide one saliva sample for CMV PCR testing. In addition, infrastructure for the study will be developed (e.g. community engagement to build the network of centers, data pipelines, digital platform, sampling workflows) and partic... Read More
Gender:
ALL
Ages:
Between 1 day and 36 months
Trial Updated:
07/25/2024
Locations: UMass Chan Medical School, Worcester, Massachusetts
Conditions: Cytomegalovirus Infections
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Genetics of Cardiovascular and Neuromuscular Disease
NCT00138931
Recruiting
We are studying the genetics of human cardiovascular and neuromuscular disease. There are many different genetic regions that have been associated with the development of cardiomyopathy. An equal number of genetic regions have been associated with muscular dystrophy and there is overlap because some of the identical genes, when mutated, produce both cardiomyopathy and muscular dystrophy. We are working to identify genes and gene mutations associated with cardiomyopathy, arrhythmias and muscular... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/25/2024
Locations: University of Chicago, Chicago, Illinois
Conditions: Cardiomyopathy, Arrhythmia, Muscular Dystrophy
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Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
NCT03901924
Recruiting
The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: The University of Chicago Medical Center, Chicago, Illinois +1 locations
Conditions: Mechanical Ventilation Complication
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Stick2PrEP Cisgender Women and Trans Individuals
NCT05165745
Recruiting
Taking a daily anti-HIV pill can protect people from HIV infection. This is called preexposure prophylaxis \[PrEP\]. Many cisgender women and trans individuals do not know this medication is available; others struggle to take the pill every day. It is important to understand attitudes and preferences about HIV prevention options, especially as new options become available. This study plans to evaluate preferences over time among cisgender women and trans individuals who are taking medication to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: Columbia University Medical Center, New York, New York
Conditions: HIV Prevention, Pre-exposure Prophylaxis
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PODER Familiar: Health Promotion for Latino Families of Children With IDD
NCT05713617
Recruiting
The goal of this clinical trial is to test a culturally tailored health promotion intervention for children with IDD and their families. First investigators will conduct a single group design pilot study of a health promotion intervention, followed by second, a small-scale randomized control trial (RCT). of the intervention with Latino parents of children with intellectual and developmental disabilities (IDD) in the Chicago, Illinois and Austin, Texas areas. The following research questions will... Read More
Gender:
ALL
Ages:
Between 6 years and 100 years
Trial Updated:
07/25/2024
Locations: University of Illinois at Chicago, Chicago, Illinois +1 locations
Conditions: Health-Related Behavior, Quality of Life, Psychological Distress, Diet, Healthy, Physical Inactivity
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First-in-Human, Phase I, Open-label, Multicenter, Dose Escalation Clinical Study
NCT06130722
Recruiting
First-in-Human, Phase I, open-label, multicenter, dose-escalation study to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary antitumor activity of FL115 in patients with advanced solid tumors who have progressed or are intolerant to current standard-of-care therapies, including immune check-point inhibitors administered in single-agent or combination use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: HOAG Memorial Hospital Presbyterian, Newport Beach, California +2 locations
Conditions: Locally Advanced/Metastatic Solid Tumors
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Improving Independent Multi-joint Arm Control After Stroke
NCT06523335
Recruiting
The purposes of this study include: 1. - To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. - To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
07/25/2024
Locations: University of Houston, Houston, Texas
Conditions: Stroke
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Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
ALL
Ages:
All
Trial Updated:
07/25/2024
Locations: RANGER & MATCH: Arizona Center for Hand Surgery, Phoenix, Arizona +48 locations
Conditions: Peripheral Nerve Injuries
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Breast Cancer Patient Engagement With Patient Reported Outcome Measure Survey
NCT03995082
Recruiting
The purpose of this research protocol is to measure Patient Reported Outcome Measures (PROMs) in breast cancer patients. PROM results will be provided to patients and providers and the investigators will evaluate the relationship between patient engagement with PROM results and patient and clinicopathologic variables, utilization of supportive and hospital services, and patient satisfaction with patient-provider communication.
Gender:
FEMALE
Ages:
All
Trial Updated:
07/25/2024
Locations: University of Colorado Hospital, Denver, Colorado +2 locations
Conditions: Breast Cancer
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Cortisol and Food Insecurity
NCT05191030
Recruiting
This study will use a within-subjects design in a sample of individuals with a range of food insecurity recruited from the Los Angeles community (N = 400; 50% men). These participants will then, in counterbalanced order, be exposed to a gold-standard laboratory stressor and a control condition, one month apart. Moderation analyses will test whether cortisol reactivity to the stressor acts as a modulator of the relationship between high levels of food insecurity and increased hyperpalatable food... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Food Insecurity
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Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis
NCT05740618
Recruiting
This study will provide important mechanistic information regarding the effect of inhaled mannitol (Bronchitol) in people with cystic fibrosis (PwCF) with moderate to severe disease who are already using elexacaftor/tezacaftor/ivacaftor (E/T/I). Many patients have already discontinued hypertonic saline and other pulmonary therapies because of the profound effect of E/T/I of their symptoms and lung function. Further, because both inhaled osmotic agents (i.e., Bronchitol, hypertonic saline \[HS\])... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Cystic Fibrosis
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