Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
Recruiting
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a healthy meal, will promote the absorption of zinc into cells, where the zinc will have greater effects on zinc-dependent metabolic processes supporting cardiovascular health. To maximize the observabi... Read More
Gender:
ALL
Ages:
Between 55 years and 70 years
Trial Updated:
10/29/2024
Locations: University of California, Davis; Department of Nutrition, Davis, California
Conditions: Zinc Deficiency, Inflammation, Metabolic Diseases, Vascular Diseases
Bevonescein for Intra-Operative Nerve Visualization in Head and Neck Surgery
Recruiting
This protocol describes prospective, open-label, blinded, randomized controlled, multicenter pivotal studies to evaluate ALM-488.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/29/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Surgery
The DRAGON 2 Trial
Recruiting
In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE/HVE (interventional group).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut +23 locations
Conditions: Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR)
Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer
Recruiting
This phase II clinical trial will study the safety and efficacy of onvansertib to treat patients with small cell lung cancer (SCLC) who have either not responded to or are unable to tolerate chemotherapy. Onvansertib is a drug that inhibits polo-like kinase 1 (PLK-1), an enzyme that is over-expressed in many cancer cells and is involved in cellular repair.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland +1 locations
Conditions: Small-cell Lung Cancer, Small Cell Lung Carcinoma
Non-weight Bearing Exercise for Accelerated Healing of Diabetic Foot Ulcers
Recruiting
The goal of this study is to improve the therapeutic management of diabetic foot ulcers (DFU). The main questions to answer are if a program of non-weight bearing exercise helps the DFU heal faster than standard wound care. This randomized clinical trial will determine how blood flow to the ulcer and whole body metabolism may be improved with exercise. Participants will be randomized to either exercise + standard wound care or standard wound care alone and undergo testing for leg blood flow, fit... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/29/2024
Locations: School of Kinesiology, Ann Arbor, Michigan
Conditions: Type2diabetes, Foot Ulcer
Enhanced Nutritional Optimization in LVAD Trial
Recruiting
The goal of this clinical trial is to assess whether a peri-operative intervention with nutritional immune modulating intervention (Ensure Surgery Immunonutrition shake) has beneficial effects on the complex interplay between gut microbiome, systemic inflammation and malnutrition that is commonly present in advanced heart failure and the adverse events associated with left ventricular assist device (LVAD) placement in hospitalized advanced heart failure patients awaiting LVAD implantation. The m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Columbia University Medical Center, New York, New York
Conditions: Heart Failure, Gut Microbiome, Nutritional Deficiency
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Recruiting
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
Gender:
ALL
Ages:
Between 6 months and 59 months
Trial Updated:
10/29/2024
Locations: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland +1 locations
Conditions: Severe Malaria, Thrombocytopenia
Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment
Recruiting
This phase 2 trial studies the side effects and best dose of tazemetostat and zanubrutinib in combination with tafasitamab and lenalidomide, and to see how well these combinations work in treating patients with large B-cell lymphoma that returned or did not respond to earlier treatment. Tazemetostat is in a class of medications called EZH2 inhibitors. It helps to stop the spread of cancer cells. Zanubrutinib is in a class of medications called kinase inhibitors. It works by blocking the action o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Saint Joseph Mercy Hospital, Ann Arbor, Michigan +10 locations
Conditions: Grade 3b Follicular Lymphoma, High Grade B-Cell Lymphoma, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements, Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Transformed Non-Hodgkin Lymphoma
Goals for Epilepsy Clinic Visits Trial
Recruiting
The purpose of this project is to conduct a trial to assess whether patients that receive a tablet-based waiting room priority communication tool (the "Epilepsy Visit Planner") have improved outcomes compared to patients that do not receive the tool. The project's hypotheses are: * Patients that receive the Epilepsy Visit Planner will have improved patient-provider communication compared to the non-planner group. * Patients that receive the Epilepsy Visit Planner will have improved quality of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Drug Resistant Epilepsy
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +431 locations
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
Interstitial Assessment of Architectural Heterogeneity in Prostate Cancer Using a Fine Needle Photoacoustic Probe
Recruiting
In this project, we will integrate the Photoacoustic (PA) technology into a prostate biopsy procedure through a fine needle probe. The needle probe will be in the shape of a biopsy needle and compatible with the needle insertion mechanism in the transrectal ultrasound (TRUS) probe. When inserted into the prostate, the fine needle PA probe will assess the histological information in its surrounding tissue without any tissue extraction. The needle probe has been tested in prostate tissue samples a... Read More
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
10/29/2024
Locations: University of Michigan Rogel Cancer Center, Ann Arbor, Michigan
Conditions: Prostate Cancer
One-Month DAPT in CABG Patients
Recruiting
The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Weill Cornell Medicine, New York, New York +11 locations
Conditions: Chronic Coronary Disease