Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +431 locations
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
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Interstitial Assessment of Architectural Heterogeneity in Prostate Cancer Using a Fine Needle Photoacoustic Probe
NCT05965180
Recruiting
In this project, we will integrate the Photoacoustic (PA) technology into a prostate biopsy procedure through a fine needle probe. The needle probe will be in the shape of a biopsy needle and compatible with the needle insertion mechanism in the transrectal ultrasound (TRUS) probe. When inserted into the prostate, the fine needle PA probe will assess the histological information in its surrounding tissue without any tissue extraction. The needle probe has been tested in prostate tissue samples a... Read More
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
10/29/2024
Locations: University of Michigan Rogel Cancer Center, Ann Arbor, Michigan
Conditions: Prostate Cancer
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One-Month DAPT in CABG Patients
NCT05997693
Recruiting
The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Weill Cornell Medicine, New York, New York +11 locations
Conditions: Chronic Coronary Disease
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Examining the Effectiveness of the Early Start Denver Model in Community Programs Serving Young Autism
NCT06005285
Recruiting
This study tests the effectiveness of the Early Start Denver Model (ESDM) in community agencies that serve young autistic children. The feasibility, usability and acceptability of the model will be explored. Understanding effectiveness of new evidence-based models will increase the quality of autism care available to more diverse children and families in more geographic locations.
Gender:
ALL
Ages:
12 months and above
Trial Updated:
10/29/2024
Locations: University of California, Davis MIND Institute, Sacramento, California
Conditions: Autism
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Sacituzumab Govitecan in Combination With Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer
NCT06040970
Recruiting
This is an open-label, Phase 1 study with a dose expansion cohort of Sacituzumab Govitecan in Combination with Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer. The goal of the study is to determine the optimal dose of sacituzumab govitecan for use in combination with cisplatin for treatment of epithelial ovarian and endometrial cancers.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Icahn School of Medicine at Mount Sinai Division of Hematology and Medical Oncology, New York, New York
Conditions: Ovarian Cancer, Malignant Neoplasm of Uterus
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Capsule Microbiota Transplant Therapy for Hidradenitis Suppurativa
NCT06058520
Recruiting
HS is relatively common in the United States with a prevalence of 0.1-1.0%. 1 HS has a dramatic impact on quality of life, significantly more so than other chronic skin diseases, such as psoriasis or atopic dermatitis (AD). HS also has a large economic impact, due to frequent emergency department and inpatient care utilization, and re-hospitalization rates similar to congestive heart failure. Unfortunately, few treatment options are effective. There is only one currently FDA-approved treatment,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hidradenitis Suppurativa
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Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
NCT06127667
Recruiting
This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are... Read More
Gender:
ALL
Ages:
Between 21 years and 95 years
Trial Updated:
10/29/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Neurotypical, Cognitively Normal
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Feasibility Study for Bevonescein-Assisted Nerve Visualization in Head & Neck Surgery
NCT06227585
Recruiting
A feasibility study to evaluate the usability of the REVEAL 475 system in patients treated with bevonescein for nerve visualization during surgery.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/29/2024
Locations: Jacobs Medical Center at UC San Diego Health, San Diego, California
Conditions: Head and Neck Surgery
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Avutometinib and Defactinib in Diffuse Gastric Cancer
NCT06487221
Recruiting
The purpose of this study is to determine if the combination study treatment with avutometinib and defactinib will prolong life in participants, is effective in decreasing the size of the tumor(s), and if it is safe in subjects with diffuse-type stomach cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Gastric Cancer, Stomach Cancer
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Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction
NCT06529679
Recruiting
The goal of this study is to determine short-term adaptations (aftereffects) in knee loading after a 20-minute split-belt treadmill training session in patients with ACL reconstruction. Our main question for this aim are: 1. Are training-mediated aftereffects in the knee joint moment greater for tied-belt walking or split-belt walking? 2. Are training-mediated aftereffects in the knee joint moment different between subjects who train early stance knee loading versus subjects who train mid-stan... Read More
Gender:
ALL
Ages:
Between 14 years and 45 years
Trial Updated:
10/29/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: ACL, ACL Injury
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Integrative Breathwork Intervention for Chronic Pain
NCT06546956
Recruiting
The proposed research is to develop and refine a multicomponent breathwork intervention, Guided Respiration Mindfulness Therapy, and to iteratively evaluate its feasibility, acceptability, and plausibility for clinically significant effects in people with chronic low back pain. This integrative breathwork intervention involves a 60-minute breathing session where the focus is to maintain a conscious connected breathing pattern (no pause between inhale and exhale), apply mindful acceptance to soma... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/29/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Chronic Low-back Pain
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Food for Thought - a Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer
NCT06582615
Recruiting
The goal of this randomized clinical trial is to learn if a healthy eating pattern called the MIND eating plan can reduce cancer-related cognitive impairment (commonly called "chemobrain") and other symptoms commonly experienced by women with newly diagnosed stage II-III triple negative breast cancer as they go through chemotherapy. The symptoms that will be measured include changes in memory and mental function, fatigue, sleep quality, anxiety, and depression. Researchers will compare measures... Read More
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
10/29/2024
Locations: Yale University, New Haven, Connecticut +1 locations
Conditions: Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Triple-Negative Breast Carcinoma
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