Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma
NCT04150640
Recruiting
This is an open label, phase II, multi-site trial evaluating the efficacy and safety of the combination of 5-FU, oxaliplatin, nal-IRI, and immunotherapy (plus trastuzumab for HER2-positive tumors) as first-line therapy for participants with advanced Esophageal and Gastric Adenocarcinoma (EGA). The investigators hypothesize that this drug combination will be better tolerated than current first-line chemotherapy combinations for this disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Esophageal Adenocarcinoma, Gastric Adenocarcinoma
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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
NCT05658913
Recruiting
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/13/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Alzheimer's Disease
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First Face Training Evaluation in Tribal Communities
NCT05998005
Recruiting
The goal of this study is to evaluate a culturally grounded training curriculum, First Face for Mental Health, in Tribal communities, using a waitlist controlled trial design. This curriculum will train Tribal community members in how to respond to youth and adults experiencing mental health crises and serve as a bridge between these individuals and the help they need. The main questions the study aims to answer are: * Does the training increase mental health knowledge, capacity and ability to... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
08/13/2024
Locations: Kootenai Tribe of Idaho, Bonners Ferry, Idaho +8 locations
Conditions: Mental Health, Substance-Related Disorders
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Mobile App-based Approach for Reducing Pain and Hazardous Drinking: a Pilot Study
NCT06281821
Recruiting
Chronic pain and heavy drinking are common co-occurring conditions among patients presenting to primary care settings. Given their impact on functioning and medical outcomes, there would be considerable benefit to developing an accessible, easily utilized, integrative approach to reduce alcohol use and pain that can be readily incorporated into the health care settings. The objective of this study is to test a modified version of a smartphone-based intervention for reducing pain and alcohol use... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Alcohol Drinking, Chronic Pain
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Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease
NCT06540989
Recruiting
The goal of this clinical trial is to learn whether noise-augmented feedback using automatic speech recognition improves intelligibility and social participation in individuals with Parkinson's disease. The main questions the investigators will address are: Does noise-augmented feedback lead to increased intelligibility, as measured by transcription accuracy scores? Does a self-managed speech protocol lead to increased social participation, as measured by the Communicative Participation Item B... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
08/13/2024
Locations: Teachers College, Columbia University, New York, New York
Conditions: Parkinson Disease
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Skin Imaging With Technologies in Development
NCT00764920
Recruiting
The purpose of this research is to develop non-invasive imaging modalities for assessment of skin. This is a pilot study which will use multiple imaging modalities to collect information on normal and lesional skin. The researchers understand that the purpose of this study is not to evaluate any particular treatment and an investigation of a new therapeutic intervention would require an additional protocol. Skin conditions to be studied include vascular lesions, pigmentary disorders, inflammator... Read More
Gender:
ALL
Ages:
7 years and above
Trial Updated:
08/12/2024
Locations: Beckman Laser Institute Medical clinic, Irvine, California
Conditions: Pigmented Skin Lesion of Uncertain Nature
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Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Chemotherapy
NCT04829539
Recruiting
This phase III trial compares BBT-CI to HEAL for the reduction of insomnia in patients with stage I-IV cancer who are receiving cancer treatment. Cancer treatment can cause side effects such as sleep problems. Sleep problems such as insomnia, are common for cancer patients. Insomnia can be described as difficulty falling asleep, waking up many times during the night or waking up earlier than patient would like. Insomnia can increase fatigue and worsen quality of life. This trial may help researc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: Kingman Regional Medical Center, Kingman, Arizona +129 locations
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
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Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
NCT06053229
Recruiting
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and mus... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/12/2024
Locations: Brigham Young University, Provo, Utah
Conditions: Massage Therapy, Muscular Atrophy
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Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair
NCT06551077
Recruiting
This study will be a prospective observation study of the use of PoRSHA for repair in patients with challenging paraesophageal hernias. One of the most challenging problems facing foregut surgeons is the large and complex paraesophageal hernia (PEH) repair in the older patient. The investigator has demonstrated good outcomes and durability with the initial use of a novel permanent autologous vascularized biologic fascial flap to reconstruct the diaphragmatic hiatus following standard hiatal her... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: The University of Chicago, Chicago, Illinois
Conditions: Paraesophageal Hernia
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Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy
NCT01771718
Recruiting
The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions for characterization of their morphologic and functional features. .
Gender:
ALL
Ages:
All
Trial Updated:
08/12/2024
Locations: Beckman Laser Institute Medical Clinic, Irvine, California
Conditions: Skin Lesion
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Individualized Vocational and Educational Support and Training for Clinical High Risk for Psychosis (InVEST)
NCT05114733
Recruiting
The purpose of this study is to test the efficacy of InVEST (Individualized Vocational and Educational Support and Training) for CHR-P (clinical high risk for psychosis) to address specific role functioning difficulties associated with the CHR-P phase. Our specific goals are: 1. Part 1: Preliminary open trial of InVEST (n = 8) to collect preliminary feasibility and acceptability data by providing the intervention, administering assessments, and collecting focus group and self-report feedback fr... Read More
Gender:
ALL
Ages:
Between 12 years and 22 years
Trial Updated:
08/12/2024
Locations: Beth Israel Deaconess Medical Center/ Massachusetts Mental Health Center, Boston, Massachusetts
Conditions: Clinical High Risk for Psychosis
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Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
NCT06136195
Recruiting
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
08/12/2024
Locations: Connecticut Mental Health Center (SAC and SATU), New Haven, Connecticut +1 locations
Conditions: Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
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