3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
NCT00935090
Recruiting
RATIONALE: Diagnostic procedures, such as 3'-deoxy-3'-\[18F\] fluorothymidine (FLT) PET imaging, may help find and diagnose cancer. It may also help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This phase I trial is studying FLT PET imaging in patients with cancer.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
06/26/2024
Locations: Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Conditions: Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Unspecified Adult Solid Tumor, Protocol Specific
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Computational Neuroscience of Language Processing in the Human Brain
NCT05222594
Recruiting
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Language, Epilepsy
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Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD)
NCT05616793
Recruiting
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of subretinal gene therapy with OPGx-001 in patients with inherited retinal degeneration due to biallelic mutations in the LCA5 gene.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
06/26/2024
Locations: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: LCA5
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IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
NCT05934669
Recruiting
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for successful and efficient procedure completion. This is the first study that will compare three intranasal medications (Intranasal Midazolam, Dexmedetomidine, and Ketamine) to evaluate the length of stay after medication administration along with patient and provider sat... Read More
Gender:
ALL
Ages:
Between 1 year and 5 years
Trial Updated:
06/26/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Laceration of Skin, Anxiety, Discharge Time
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Enzalutamide Implants (Enolen) in Patients With Prostate Cancer
NCT06257693
Recruiting
The study is to assess whether the Enolen is safe and delivers anti-androgen medication locally in patients that are planning for radical prostatectomy.
Gender:
MALE
Ages:
21 years and above
Trial Updated:
06/26/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Prostate Adenocarcinoma
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Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder
NCT06471374
Recruiting
The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadian rhythms and sensitivity to light compared to healthy controls. The investigators will also test a new method of predicting circadian rhythms form a blood sample.
Gender:
ALL
Ages:
Between 16 years and 30 years
Trial Updated:
06/26/2024
Locations: University of Colorado, Boulder, Colorado +1 locations
Conditions: Delayed Sleep Phase Syndrome, Delayed Sleep Phase
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MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
NCT03053193
Recruiting
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive design, where additional targeted substudies and arms can be added after the initial study is opened.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: CHS Grandview, Birmingham, Alabama +133 locations
Conditions: Breast Cancer
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Ubuntu - I Am Because We Are
NCT05314179
Recruiting
The program will provide Advocacy and Support for Black patients with advanced-stage cancer in the Pittsburgh area. The goals are to: 1) provide a community-based, trained companion to journey alongside the patient with advanced cancer, 2) to help the individual explore meaning and create legacy, 3); offer support and navigation for practical needs of illness (e.g., financial assistance for food and housing, accessing and affording medications, transportation); and 4) to provide support and conn... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Metastatic Cancer
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Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
NCT05661084
Recruiting
This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/26/2024
Locations: Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts
Conditions: Dementia, Memory Loss, Alzheimer Disease, Executive Dysfunction, Mobility Limitation
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Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
NCT05937854
Recruiting
The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, and lung function. Veterans who enroll in the trial will be allocated by chance to either active tadalafil or an i... Read More
Gender:
ALL
Ages:
Between 35 years and 89 years
Trial Updated:
06/26/2024
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +4 locations
Conditions: Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Dyspnea
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RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
NCT06305793
Recruiting
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic ta... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: All sites listed under NCT06305780, Durham, North Carolina
Conditions: Long COVID, Long Coronavirus Disease 2019 (Covid19), Long Covid-19
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Exploratory Study for Toivoa-001 on Human Factors
NCT06477913
Recruiting
The Study will evaluate Rauha as an experimental digital therapeutic for persons with Disabilities suffering from anxiety and/or depression. The study will evaluate completion rates of the program and survey the user's experience upon completion. Changes in anxiety and depression scores will be monitored during the study.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
06/26/2024
Locations: The Steven A. Cohen Military Family Clinic at Endeavors, San Antonio, Texas
Conditions: Anxiety Depression, Disability Physical
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