Rapamycin - Effects on Alzheimer's and Cognitive Health
NCT04629495
Recruiting
This study will evaluate the safety, tolerability, and feasibility of 12 month oral rapamycin treatment in older adults with amnestic mild cognitive impairment (aMCI) and early stage Alzheimer's disease (AD).
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
08/12/2024
Locations: Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, San Antonio, Texas
Conditions: Mild Cognitive Impairment, Alzheimer Disease
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ROX Index for the Timing of Intubation in Nasal High Flow
NCT04707729
Recruiting
Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of NHF failure and those with a high probability of success. Whether or not the ROX index may improve patient outcome remains to be shown. To do so, a strategy using the ROX index must lead to earlier in... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/12/2024
Locations: Rush University Chicago Hospital, Chicago, Illinois +11 locations
Conditions: Acute Hypoxemic Respiratory Failure
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Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Chemotherapy
NCT04829539
Recruiting
This phase III trial compares BBT-CI to HEAL for the reduction of insomnia in patients with stage I-IV cancer who are receiving cancer treatment. Cancer treatment can cause side effects such as sleep problems. Sleep problems such as insomnia, are common for cancer patients. Insomnia can be described as difficulty falling asleep, waking up many times during the night or waking up earlier than patient would like. Insomnia can increase fatigue and worsen quality of life. This trial may help researc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: Kingman Regional Medical Center, Kingman, Arizona +129 locations
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
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Individualized Vocational and Educational Support and Training for Clinical High Risk for Psychosis (InVEST)
NCT05114733
Recruiting
The purpose of this study is to test the efficacy of InVEST (Individualized Vocational and Educational Support and Training) for CHR-P (clinical high risk for psychosis) to address specific role functioning difficulties associated with the CHR-P phase. Our specific goals are: 1. Part 1: Preliminary open trial of InVEST (n = 8) to collect preliminary feasibility and acceptability data by providing the intervention, administering assessments, and collecting focus group and self-report feedback fr... Read More
Gender:
ALL
Ages:
Between 12 years and 22 years
Trial Updated:
08/12/2024
Locations: Beth Israel Deaconess Medical Center/ Massachusetts Mental Health Center, Boston, Massachusetts
Conditions: Clinical High Risk for Psychosis
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Ketone Ester and Acute Salt (KEAS) in Young Adults
NCT05545501
Recruiting
Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs the ability of systemic blood vessels and the kidneys to control blood pressure, which contributes to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. There is a critical need for strategies to counteract the effects of... Read More
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
08/12/2024
Locations: Auburn University, Auburn, Alabama
Conditions: Salt; Excess, Hypertension
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Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
NCT06053229
Recruiting
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and mus... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/12/2024
Locations: Brigham Young University, Provo, Utah
Conditions: Massage Therapy, Muscular Atrophy
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Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning
NCT06332144
Recruiting
The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: 1. whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; 2. how children's brains automatically learn patterns from speech and prints; 3. whether children's learning in th... Read More
Gender:
ALL
Ages:
Between 72 months and 90 months
Trial Updated:
08/12/2024
Locations: Northeastern University, Boston, Massachusetts +1 locations
Conditions: Autism Spectrum Disorder, Language Development, Literacy
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General Pre-Trial Screening Protocol for Infectious Diseases Research
NCT06463704
Recruiting
The purpose of this general screening protocol is to facilitate recruitment into studies conducted at the Center for Virology and Vaccine Research (CVVR) or Division of Infectious Diseases at Beth Israel Deaconess Medical Center. This general screening protocol will help to determine the eligibility of potential volunteers for any vaccine or therapeutic trials open for recruitment or soon to be opened.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Healthy Volunteers
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Home-Based Cardiac Rehabilitation for Patients With Heart Failure
NCT06479876
Recruiting
The vast majority of individuals with heart failure do not participate in center based cardiac rehabilitation (CBCR). While steps to increase utilization of CBCR are important, many individuals will still not participate for a variety of reasons. This pilot randomized controlled trial is evaluating a home-based cardiac rehabilitation (HBCR) intervention delivered using a custom app and digital tools in patients with heart failure. After a brief roll-in period, participants are randomized to one... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Cardiovascular Diseases
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Enhanced SUPport for Initiation and paRticipation in a FOOD is Medicine Program
NCT06500962
Recruiting
The purpose of this research is to see if offering more navigation and text-message support will help increase participation and engagement in a Food is Medicine program. The study will recruit people currently participating in cardiac rehabilitation. People will be randomly assigned to 1 of 4 study groups: navigation, text-messaging, both, or neither. People will complete surveys at the start of the study and after 3 months. After 3 months, we will compare how many Food is Medicine meals or gro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Cardiac Rehabilitation, Nutrition, Healthy, Nutrition Poor
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Surgeon Core-strengthening Program as a Modifier for Exertion Associated With Vaginal Surgery
NCT06525701
Recruiting
Work-related musculoskeletal pain and injury is a growing concern in surgery. Vaginal surgery has unique ergonomic risks, but no studies have addressed the potential for an exercise regimen to reduce physical strain by vaginal surgeons
Gender:
ALL
Ages:
All
Trial Updated:
08/12/2024
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Musculoskeletal Pain, Musculoskeletal Injury
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Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair
NCT06551077
Recruiting
This study will be a prospective observation study of the use of PoRSHA for repair in patients with challenging paraesophageal hernias. One of the most challenging problems facing foregut surgeons is the large and complex paraesophageal hernia (PEH) repair in the older patient. The investigator has demonstrated good outcomes and durability with the initial use of a novel permanent autologous vascularized biologic fascial flap to reconstruct the diaphragmatic hiatus following standard hiatal her... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2024
Locations: The University of Chicago, Chicago, Illinois
Conditions: Paraesophageal Hernia
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