Tissue Repository: CTCL Collection Protocol
NCT02840747
Recruiting
This document is a protocol for a non-interventional human research study in which the investigator hopes to better understand the changes that take place in T cells in Cutaneous T-cell lymphoma (CTCL). The purpose of this study is to establish a protocol for the collection and storage of tissue samples from patients with CTCL for future research studies. Collection and storage of tissue samples from control patients will also be carried out.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Lymphoma, T-Cell, Cutaneous, Lymphomatoid Papulosis, Sézary Syndrome
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Restoration of Hypoglycemia Awareness With Metoclopramide
NCT03970720
Recruiting
Metoclopramide is a drug approved by the FDA for gastroesophageal reflux and to relieve symptoms in adults with acute and recurrent diabetic gastroparesis. The objective of this study is to determine whether metoclopramide can improve hypoglycemia awareness and decrease the incidence of hypoglycemia in type 1 diabetes patients with hypoglycemia unawareness.
Gender:
ALL
Ages:
Between 20 years and 60 years
Trial Updated:
04/30/2024
Locations: University of Kentucky, Lexington, Kentucky +1 locations
Conditions: Hypoglycemia Unawareness
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The COCOA-PAD II Trial
NCT04794530
Recruiting
Among people with peripheral artery disease (PAD) age 55 and older, the investigators will test the hypothesis that PAD participants randomized to cocoa flavanols will have greater improvement or less decline in six-minute walk distance at six-month follow-up, compared to those randomized to placebo. The study will randomize 190 participants with PAD age 55 and older to one of two groups for six months: cocoa flavanols vs placebo. Our primary outcome is change in six-minute walk distance at six-... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
04/30/2024
Locations: Northwestern University, Chicago, Illinois +2 locations
Conditions: Peripheral Artery Disease
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Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD
NCT05614115
Recruiting
The purpose of this study is to find out if empagliflozin, a new diabetic medication that has been shown to be very effective in lowering the risk of heart failure, is safe and tolerated in dialysis patients. In the recent years, empagliflozin has become a major tool to prevent heart failure hospitalization and to reduce the risk for cardiovascular death in diabetic and non-diabetic patients. Although patients with severe chronic kidney disease and ESKD have very high risk of heart failure and c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: University of Utah, Salt Lake City, Utah
Conditions: End-stage Kidney Disease, Kidney Disease, Chronic, Dialysis, Diabetic, Non-diabetic, Kidney Dysfunction, Kidney Failure, Hemodialysis
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Methylphenidate and Response to Alcohol Cues
NCT06063200
Recruiting
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues. The study will observe the effects of methylphenidate or a placebo on attentional bias and craving responses to alcohol cues through fMRI, EEG, and behavioral testing. Participants will be involved in one remote and two in-person sessions.
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
04/30/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder
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Clinic-Based School Readiness Coaching
NCT06390215
Recruiting
The goal of this clinical trial is to examine how a clinic-based school readiness coaching session conducted by a community health worker for parents of 3-5-year-olds affects children's School Readiness (SR) skills and parents early SR knowledge and behaviors. The main questions it aims to answer are: What impact does the clinic-based coaching session have on preschool-aged children's school readiness skills and their parents' confidence in supporting and practicing early math and literacy behav... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/30/2024
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: School Readiness
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Strengthening of the First Dorsal Interosseous for Thumb Carpometacarpal Osteoarthritis
NCT03177577
Recruiting
To determine the effect of first dorsal interosseus (FDI) strengthening in patients with thumb carpometacarpal (CMC) osteoarthritis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Thumb Osteoarthritis, First Dorsal Interosseous Strengthening
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A Study of sEphB4-HSA in Kaposi Sarcoma
NCT03993106
Recruiting
sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to learn if sEphB4-HSA will decrease the number or size of Kaposi sarcoma lesions in people.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: AIDS Healthcare Foundation, Beverly Hills, California +2 locations
Conditions: Kaposi Sarcoma
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BabyStrong Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Paired Bottle Feeding to Improve Oral Feeding
NCT04849507
Recruiting
Feeding is critical for pre-term infants and term infants with hypoxic ischemic brain injury, in order to be discharged home with their families and avoid a gastrostomy tube (G-tube) placement. The proposed study will employ a novel system that stimulates the vagus nerve through the skin in front part of the ear, the BabyStrong feeding system, to delivered transcutaneous auricular vagus nerve stimulation (taVNS) paired with oral feedings daily for 10 days. In an earlier study at Medical Universi... Read More
Gender:
ALL
Ages:
Between 2 weeks and 5 months
Trial Updated:
04/30/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Infant Feeding Problems, taVNS
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Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831
Recruiting
This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Kaiser Permanente Center, Vallejo, California +82 locations
Conditions: Endometrial Cancer
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Trial to Evaluate Safety, PD & PK of IV Study Drug, QN-302, in Pts w/ Advanced or Metastatic Solid Tumors
NCT06086522
Recruiting
Goal: learn about QN-302 in patients with solid tumors (metastatic, or advanced cancer). Main questions: * What does the study drug do to human body (Pharmacodynamics \[='PD'\]) * What does the body do to study drug (how processed in body (Pharmacokinetics \[='PK'\]) - Safety Study drug by intravenous infusion ('IV') once weekly for 3 weeks every 4-week 'cycle.' Study treatment continues as long as patient and their study doctor agree that study treatment is in the best interest of the patien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: HonorHealth, Scottsdale, Arizona +3 locations
Conditions: Solid Tumor
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A Multi-site Clinical Evaluation of Capillary Blood Samples Collected Using the Tasso+SST Device for Downstream Analyte Testing
NCT06392269
Recruiting
This is a prospective, multi-center study within the U.S. Study participants will take part in two study visits a minimum of 14 days apart. During each visit, participants will self-collect capillary blood samples. Additionally, a healthcare provide will obtain capillary and venous serum samples. All capillary samples will be collected from the upper arm using the Tasso+ device paired with a commercially-available serum separator gel microtainer. The samples will be shipped to a clinical laborat... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/30/2024
Locations: Tasso Research Clinic, Seattle, Washington
Conditions: Serum Analytes
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