Cytomegalovirus (CMV) Transmission and Immune Tracking (TransmIT) Study
NCT06522880
Recruiting
The goal of STAGE I of the CMV TransmIT Study is to determine the prevalence of CMV shedding in children up to and including 36 months of age in large group childcare centers and in staff who regularly work at the center. Participants will complete a health survey and provide one saliva sample for CMV PCR testing. In addition, infrastructure for the study will be developed (e.g. community engagement to build the network of centers, data pipelines, digital platform, sampling workflows) and partic... Read More
Gender:
ALL
Ages:
Between 1 day and 36 months
Trial Updated:
07/25/2024
Locations: UMass Chan Medical School, Worcester, Massachusetts
Conditions: Cytomegalovirus Infections
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Improving Independent Multi-joint Arm Control After Stroke
NCT06523335
Recruiting
The purposes of this study include: 1. - To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. - To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
07/25/2024
Locations: University of Houston, Houston, Texas
Conditions: Stroke
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Investigation on the Bidirectional Cortical Neuroprosthetic System
NCT03161067
Recruiting
The Bidirectional Cortical Neuroprosthetic System (BiCNS) consists of NeuroPort Microelectrode Array Systems and NeuroPort Electrodes (Sputtered Iridium Oxide Film), Patient Pedestals, the NeuroPort BioPotential Signal Processing System, and the CereStim C96 Programmable Stimulator. The goals of this early feasibility study consist of safety and efficacy evaluations of this device.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
07/24/2024
Locations: Department of Neurology, Baltimore, Maryland
Conditions: Tetraplegia, Quadriplegia
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Efficacy of Non-invasive Vagus Nerve Stimulation for Treatment of Low Weight Eating Disorders
NCT05554172
Recruiting
This project includes a 4-week randomized trial comparing pre-meal vagal nerve stimulation (taVNS) to pre-meal sham stimulation. The aims will assess if taVNS results in greater satisfaction, greater calorie consumption, less self-reported fullness, decrease in eating disorder symptoms, and less anxiety than sham stimulation.
Gender:
ALL
Ages:
Between 14 years and 22 years
Trial Updated:
07/24/2024
Locations: Department of Psychiatry, Eating and Weight Disorders Program, New York, New York
Conditions: Anorexia Nervosa
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Expanding Medication-Assisted Therapies in Central Asia
NCT05579470
Recruiting
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the most cost-effective strategy to prevent new HIV infections, and more effective when combined with antiretroviral therapy (ART). The investigators propose to use the Network for the Improvement of Addiction Treatment (NIATx) implementation strategy to scale-up OAT in three... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: Yale University, New Haven, Connecticut +3 locations
Conditions: Opioid Use Disorder
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Early Life Feeding Exposure and Infant Immune and Health Status.
NCT05986539
Recruiting
Background: Although breastfeeding has known protective effects, such as preventing childhood obesity, the specific mechanisms remain unclear. Idaho has a high breastfeeding initiation rate (92%) but a significant prevalence of childhood obesity (30.5% overweight/obese). Limited research exists on the impact of maternal inflammation, maternal body mass index (BMI), C-reactive protein (CRP), and interleukin-6 (IL-6) concentrations in breastmilk on infant health outcomes, especially in healthy ful... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: University of Idaho, Moscow, Idaho
Conditions: Maternal Behavior, Maternal Obesity, Breast Milk Collection, Infant Development
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Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis
NCT06194123
Recruiting
The objective of this study is to evaluate how well the study product, Crest Daily Whitening Serum, alleviates Xerostomia and perceived halitosis over 1 week of use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: Tufts University School of Dental Medicine, Boston, Massachusetts
Conditions: Xerostomia, Halitosis
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A Study of AMDX-2011P in Participants With Alzheimer's Disease
NCT06514001
Recruiting
The purpose of this study is to assess safety, tolerability, plasma pharmacokinetics and biologic activity of a single intravenous dose of AMDX-2011P in participants with Alzheimer's Disease (AD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: Associated Retina Consultants, Phoenix, Arizona +2 locations
Conditions: Alzheimer Disease
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Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251
Recruiting
A multicenter, open-label Phase 2b study of selinexor (KPT-330) in participants with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have no therapeutic options of demonstrated clinical benefit.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: UACC Arizona, Tucson, Arizona +175 locations
Conditions: Diffuse Large B-cell Lymphoma
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Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics
NCT03348280
Recruiting
This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.
Gender:
ALL
Ages:
Between 25 years and 80 years
Trial Updated:
07/23/2024
Locations: Barnes-Jewish & Washington University Diabetes Center, Saint Louis, Missouri +1 locations
Conditions: Diabetes Mellitus, Type 2, Hypertension, Vitamin D Deficiency
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Post-authorization Safety Study of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Treated With Mogamulizumab
NCT04014374
Recruiting
This is a non-interventional cohort study evaluating non-relapse mortality and toxicities in patients with CTCL or ATLL treated with mogamulizumab pre- or post- alloHCT for patients transplanted beginning January 1, 2012 until accrual is complete.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: CIBMTR, Milwaukee, Wisconsin
Conditions: Leukemia/Lymphoma, Cutaneous T Cell Lymphoma, ATLL
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Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose
NCT04278898
Recruiting
The goal of this study is to target the neurobiology of restricted and repetitive behaviors in children with autism spectrum disorder using N-acetylcysteine (NAC), a well-tolerated nutritional supplement that has shown promise for reducing symptom severity in recent small-scale trials. The findings from this research will shed light on the mechanisms of action underlying the clinical benefits of NAC.
Gender:
ALL
Ages:
Between 3 years and 12 years
Trial Updated:
07/23/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism Spectrum Disorder
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