AZD6738 for Patients With Progressive MDS or CMML
Recruiting
This research study is studying a research drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia .
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: BIDMC, Boston, Massachusetts +3 locations
Conditions: Leukemia, Myelodysplastic Syndrome
The Role of Oxytocin in the Second Stage of Labor
Recruiting
This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.
Gender:
FEMALE
Ages:
All
Trial Updated:
03/12/2024
Locations: Barnes Jewish Hospital, Saint Louis, Missouri
Conditions: Labor Complication
Targeting Insomnia in School Aged Children With Autism Spectrum Disorder
Recruiting
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 4 sessions of behavioral therapy for sleep problems followed by 4 bimonthly booster sessions. Children and their families will be randomly assigned to one of three conditions: cognitive behavioral therapy (in-person), cognitive behavioral therapy (remote), or behavioral therapy (remote). Arousal will be measured through heart-rate variability. Sleep and secondary outcomes (child daytime behavior, parent s... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/12/2024
Locations: Thompson Center for Autism and Neurodevelopmental Disorders, Columbia, Missouri
Conditions: Insomnia Chronic, Autism Spectrum Disorder
Multimodal Machine Learning Characterization of Solid Tumors
Recruiting
This research study wants to develop advanced imaging methods to more accurately characterize prostate cancer or solid tumor aggressiveness. This observational study involves \[18F\]DCFPyL positron emission tomography and magnetic resonance imaging (PET/MRI)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Adenocarcinoma of Prostate, Radical Prostatectomy, Hepatocellular Carcinoma (HCC), Glioma, Prostate Cancer, Renal Cell Carcinoma (RCC)
Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
Recruiting
This cross-sectional prevalence assessment study involves a single blood draw in specific patient populations to assess for enzymatic and genomic evidence for acquired pyruvate kinase deficiency.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pyruvate Kinase Deficiency, Pyruvate Kinase Deficiency Anemia, Hereditary Hemolytic Anemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm, Clonal Myeloid Neoplasm, Myeloproliferative Neoplasm, Acute Myeloid Leukemia, Clonal Cytopenia of Undetermined Significance, Other Clonal Myeloid Neoplasm, Unexplained Coombs-negative Non-immune Hemolytic Anemia
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
Recruiting
Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the management of post-limb amputation pain. We will use the data that we collect to inform the design of a larger, appropriately powered study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Maine Medical Center, Portland, Maine
Conditions: Pain, Postoperative, Amputation
177Lu-DOTA-EB-TATE in Adult Patients With Advanced, Well- Differentiated Neuroendocrine Tumors
Recruiting
This is a Phase I clinical trial to assess the safety and dosimetry profiles of 177Lu-DOTA-EB-TATE in patients with advanced, metastatic or inoperable, somatostatin receptor-positive, well-differentiated GEP-NETs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Memorial Sloan Kettering Cancer Center, New York, New York
Conditions: Neuroendocrine Tumors
The Synchrony Study: Examining Music Training for Children With FASD
Recruiting
The goal of this clinical trial is to examine if music training improves behavioral or cognitive performance in children with prenatal alcohol exposure who meet research criteria for a fetal alcohol spectrum disorder. The main questions it aims to answer are: * Does music training improve behavioral regulation for children with an FASD * Does music training improve cognitive performance (attention and working memory) for children with an FASD. The study has two interventions for each participa... Read More
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
03/12/2024
Locations: The Mind Research Network, Albuquerque, New Mexico
Conditions: Fetal Alcohol Spectrum Disorders
Risk-ADAPTed Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation
Recruiting
This is a prospective, single-arm, phase II study. Patients will be treated with an allogeneic stem cell transplantation (AHSCT) using fludarabine, melphalan and total body irradiation (TBI) conditioning with different melphalan and TBI doses based on patient- and disease-related risk.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/12/2024
Locations: Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, Hematologic Malignancies
Biomarkers Related to Bone in Pediatric Gaucher Disease
Recruiting
Aims of the observational study is to establish novel blood-based biomarkers for grading bone disease in pediatric patients with Gaucher disease (GD). Patients with clinically confirmed GD: deficient GCase enzyme activity and corresponding genetic analysis will be eligible for enrollment. Levels of Lyso-Gb1, chitotriosidase, and CCL18 will be established for future bone biomarkers correlation analysis. Skeletal involvement will be assessed using standard clinical diagnostic tools, such as skelet... Read More
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
03/12/2024
Locations: Lysosomal and Rare disorder research and treatment center, Fairfax, Virginia
Conditions: Gaucher Disease, Bone Diseases
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Recruiting
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
LOWER: Lomitapide Observational Worldwide Evaluation Registry
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Brookwood Baptist Medical Center, Birmingham, Alabama +74 locations
Conditions: Homozygous Familial Hypercholesterolemia