A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)
Recruiting
This open-label, multicenter, within-participant dose escalation study examining up to 2 dose levels of DISC-3405 will assess the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of DISC-3405 in participants with polycythemia vera (PV).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Mayo Clinic in Arizona, Phoenix, Arizona +4 locations
Conditions: Polycythemia Vera (PV)
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
Recruiting
A phase 3b, Randomized, Controlled Trial of Nadofaragene Firadenovec vs. Observation in Participants with Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR NMIBC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of South Alabama (USA) Health System - USACM, Mobile, Alabama +32 locations
Conditions: Intermediate Risk Non-Muscle Invasive Bladder Cancer
Self-efficacy-based Auditory Rehabilitation With Over-the-Counter Hearing Aids
Recruiting
This goal of this study is to learn if a new audiology treatment process called the self-efficacy-based auditory rehabilitation (SEBAR) can improve confidence and success with over-the-counter (OTC) hearing aids. The main questions it aims to answer are: * Can the SEBAR improve participants' confidence related to managing their over-the-counter hearing aids? * Can the SEBAR improve participants' willingness to adopt over-the-counter hearing aids, their satisfaction, quality of life, and their... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/13/2025
Locations: Department of Audiology, University of Arkansas for Medical Sciences, LIttle Rock, Arkansas
Conditions: Hearing Loss, Sensorineural
A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.
Recruiting
This study is to investigate the ability of LXE408 to reduce or remove the level of parasites in the blood of people with chronic Chagas disease. Participants must have chronic Chagas disease without severe organ dysfunction.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/13/2025
Locations: Boston Medical Center, Boston, Massachusetts +14 locations
Conditions: Chagas Disease
A Study of Vosoritide Versus Placebo in Children With Hypochondroplasia Aged 0 to < 36 Months
Recruiting
The purpose of this study is to evaluate the safety and efficacy of daily administration of vosoritide in participants with HCH aged 0 to \< 36 months over a 52-week period.
Gender:
ALL
Ages:
Between 0 months and 36 months
Trial Updated:
08/13/2025
Locations: Phoenix Children's Hospital - Thomas Campus (Main), Phoenix, Arizona +18 locations
Conditions: Hypochondroplasia
Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata
Recruiting
This study evaluates the safety and effectiveness of deuruxolitinib in adolescents aged 12 to less than 18 years who have 50% or greater scalp hair loss.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/13/2025
Locations: Total Skin And Beauty Dermatology Center, Birmingham, Alabama +21 locations
Conditions: Alopecia Areata
Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery
Recruiting
The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Duke Univeristy, Durham, North Carolina +1 locations
Conditions: Brain Function, Hemiarch Cardiac Procedure
A Study to Examine Anktiva for the Treatment of COVID-19.
Recruiting
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/13/2025
Locations: Chan Soon-Schiong Institute for Medicine (CSSIFM), El Segundo, California
Conditions: Long COVID, Long COVID Syndrome, Long Covid 19
Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)
Recruiting
The primary objective of this study is to evaluate the safety and tolerability of subcutaneous (SC) tarlatamab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California +28 locations
Conditions: Extensive Stage Small Cell Lung Cancer
SIMPLAAFY Clinical Trial
Recruiting
The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following post-implant with the WATCHMAN FLX Pro device in a commercial clinical setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +77 locations
Conditions: Atrial Fibrillation, Stroke, Bleeding
Task Practice and Spinal Cord Stimulation
Recruiting
The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity. Transcutaneous stimulation has been shown to improve motor function in some individuals with chronic spinal cord injury. The study intends to explore scientifically the association between higher stimulation frequencies and spasticity/hypertonicity.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
08/13/2025
Locations: University of Miami - Christine E. Lynn Rehabilitation Center, Miami, Florida +1 locations
Conditions: Spinal Cord Injury Cervical, Spastic
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
Recruiting
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER. The target sample will be up to 125 patients enrolled to achieve 100 evaluable at 6 months of follow-up. Enrollment will occur at up to eight centers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota +5 locations
Conditions: Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation