Providing an Optimized and Empowered Pregnancy for You (POPPY) Aim 3: Randomized Controlled Trial
Recruiting
The PᵌOPPY study is designed to support the American Heart Association's mission to improve maternal/infant health outcomes and address inequities in maternal/infant health care. The P3OPPY Project is one of five projects within the American Heart Association P3 EQUATE Network. The overarching goal of the P3 EQUATE American Heart Association Health Equity Research Network (HERN) is to promote equity in Maternal and Infant Health outcomes by identifying innovative and cost-effective strategies to... Read More
Gender:
FEMALE
Ages:
Between 16 years and 49 years
Trial Updated:
08/13/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Pregnancy Complications, Maternal Distress, Adverse Birth Outcomes, Infant Conditions
Rapid Response of Stem Cells and Immune Cells for Efficacy
Recruiting
The goal for this clinical trial is to compare rapid effects of four products on stem cells, immune activation, and mitochondrial function. A double-blind, placebo-controlled, cross-over study design will be used.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/13/2025
Locations: NIS Labs, Klamath Falls, Oregon
Conditions: Stem Cell Surveillance
Comparing Integrative Interventions for Chronic Pelvic Pain
Recruiting
The researchers will conduct a pilot randomized trial to assess functional changes with two different remote integrative non-pharmacologic interventions for women with chronic pelvic pain (CPP). The study team will compare a novel web-based, cognitive-behavioral program designed for patients with CPP and a commercially available physical activity remote application. The team aims to gather information about differences in sexual function, physical function, pain, and quality of life.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
08/13/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Pelvic Pain
Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery
Recruiting
The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Duke Univeristy, Durham, North Carolina +1 locations
Conditions: Brain Function, Hemiarch Cardiac Procedure
Task Practice and Spinal Cord Stimulation
Recruiting
The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity. Transcutaneous stimulation has been shown to improve motor function in some individuals with chronic spinal cord injury. The study intends to explore scientifically the association between higher stimulation frequencies and spasticity/hypertonicity.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
08/13/2025
Locations: University of Miami - Christine E. Lynn Rehabilitation Center, Miami, Florida +1 locations
Conditions: Spinal Cord Injury Cervical, Spastic
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
Recruiting
This research is being done to test the feasibility of 24-48 hours of water-only fasting to improve delivery of 4 cycles of chemotherapy in those receiving breast cancer treatment either before or after surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Sibley Memorial Hospital, Washington, District of Columbia
Conditions: Breast Cancer, Early-stage Breast Cancer
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
Recruiting
Genes contain genetic code which tell the body which proteins to make. Many types of cancer are caused by changes, or mutations, in a gene called KRAS. Researchers are looking for ways to stop the actions of abnormal proteins made from the mutated KRAS gene. ASP5834 is being studied in people with solid tumors who have certain KRAS gene mutations. Some people with solid tumors of the colon or rectum (colorectal cancer), will be given ASP5834 with panitumumab. Panitumumab is a treatment for colo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: START Midwest, Grand Rapids, Michigan +2 locations
Conditions: Solid Tumor, Non-Small-Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer
SIMPLAAFY Clinical Trial
Recruiting
The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following post-implant with the WATCHMAN FLX Pro device in a commercial clinical setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +77 locations
Conditions: Atrial Fibrillation, Stroke, Bleeding
Breathwork Intervention for Posttraumatic Stress
Recruiting
The goal of this single-site, single-arm pilot study is to examine the impact of breathwork training for posttraumatic stress symptoms in an adult veteran population. Participants will complete a single, in-person breathwork session (2 hours) led by a certified breathwork facilitator and engage in an integration session (30 minute) with a licensed psychologist. Participants will be invited to engage in two, optional, virtual follow up breathwork sessions (40 minute practice each) during weeks 2... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Diamond Rose Sanctuary, Branford, Connecticut +1 locations
Conditions: PTSD
Methamphetamine and Troriluzole
Recruiting
This will be a human laboratory study evaluating the influence of troriluzole treatment on the effects of methamphetamine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/13/2025
Locations: Psychopharmacology of Addiction Laboratory, Lexington, Kentucky
Conditions: Methamphetamine Use Disorder
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Recruiting
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Banner MD Anderson Cancer Center ( Site 0181), Gilbert, Arizona +155 locations
Conditions: Carcinoma, Non-Small-Cell Lung
Home Blood Transfusions
Recruiting
This is a pilot single arm study to evaluate the feasibility and acceptability of a home blood transfusion program. Patients will be enrolled with hematologic malignancies and other bone marrow failure syndromes who are transfusion dependent and interested in a home blood transfusion program. Participants enrolled in the study will receive 1-5 units of blood products at home. Data on barriers to administration will be recorded. Surveys and qualitative interviews will be completed to better under... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Hematologic Malignancy, Myelodysplastic Syndromes, Acute Myeloid Leukemia, Transfusion Dependent Cytopenias