Ruxolitinib for Premalignant Breast Disease
NCT02928978
Recruiting
This study is evaluating how ruxolitinib affects premalignant breast cells. One half of the study participants will receive ruxolitinib for approximately 15 days, and the other half will receive a placebo (sugar pill) for approximately 15 days. Once study participants have completed their ruxolitinib or placebo, participants will undergo surgery to remove the premalignant breast tissue.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama +6 locations
Conditions: Ductal Carcinoma In Situ, Atypical Lobular Hyperplasia, Atypical Ductal Hyperplasia, Lobular Carcinoma In Situ
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Cortisone Shots for Neck Pain
NCT03534531
Recruiting
The purpose of this study is to determine if cortisone shots in the neck are helpful in patients with certain MRI findings. Additionally, the investigators hope to learn if cervical facet joint steroid injections are beneficial in the subset of patients with MRI findings consistent with facet joint synovitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: Stanford University, Palo Alto, California +2 locations
Conditions: Neck Pain, Cervicalgia, Facet Joint Pain
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Blood Pressure-Improving Control Among Alaska Native People" (BP-ICAN)
NCT03872856
Recruiting
The investigators have designed a group randomized, multi-level, sustainable stroke and cardiovascular disease (CVD) prevention trial - "Blood Pressure: Improving Control among Alaska Native People" (BP-ICAN) - that targets blood pressure control among Alaska Native and American Indian people diagnosed with hypertension. Washington State University will assist with design, provides general scientific and clinical consulting, will help guide implementation and conduct statistical analyses. The pu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: Anchorage Native Primary Care Center, Anchorage, Alaska +1 locations
Conditions: Hypertension
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Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
NCT04209543
Recruiting
This is a two-part study designed to evaluate the effect of Estetrol (E4) 15 or 20 mg, or placebo on the severity and frequency of vasomotor symptoms (VMS) (Efficacy Study Part) and the safety of E4 20 mg (Endometrial and General Safety Study Part)
Gender:
Female
Ages:
Between 40 years and 65 years
Trial Updated:
05/09/2022
Locations: Precision Trials AZ, LLC, Phoenix, Arizona +188 locations
Conditions: Vasomotor Symptoms, Menopausal Symptoms
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Reversing Glucose and Lipid-mediated Vascular Dysfunction
NCT04832009
Recruiting
The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
05/09/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Blood Pressure, Hypertension
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Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery
NCT05092828
Recruiting
This study aims to compare the effects of intrathecal morphine to traditional pain management strategies on post-operative recovery for deformity surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2022
Locations: Sonoran Spine in Collaboration with HonorHealth, Tempe, Arizona +1 locations
Conditions: Low Back Pain
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Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus
NCT04187521
Recruiting
The hypothesis for this study is that women with different physiologic subtypes of gestational diabetes (GDM) (insulin secretion deficit vs. insulin sensitivity deficit) will differ in their glycemic responses to meals with different portions of dietary macronutrients. Investigators will determine GDM subtype based on glucose and insulin levels taken at multiple time points during an oral glucose tolerance test. Participants will consume two meals with different macronutrient content while weari... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Gestational Diabetes
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Rib Fixation for Clinically Severe Rib Fractures From Trauma
NCT02595593
Recruiting
This is a multicenter randomized study investigating the differences in clinical outcomes of patients between two standard of care pathways for rib trauma: patients who receive rib fixation versus patients who receive modern critical care and pain control after sustaining clinically significant rib fractures from trauma.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/07/2022
Locations: Lawnwood Regional Medical Center, Fort Pierce, Florida +9 locations
Conditions: Rib Fracture, Flail Chest
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Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
NCT03591302
Recruiting
The study will determine whether patients with functioning Human Leukocyte Antigen (HLA) matched kidney transplants for at least one year and who want to discontinue immunosuppressive drugs can be treated with Total Lymphoid Irradiation (TLI) and rabbit Anti-Thymocyte Globulin (rATG) and an HLA matched donor hematopoietic progenitor cell infusion such that their drugs are successfully withdrawn while maintaining normal renal function.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/06/2022
Locations: Stanford University Medical Center, Palo Alto, California
Conditions: Immune Tolerance
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Buprenorphine Treatment Engagement and Overdose Prevention
NCT03677986
Recruiting
Office-based buprenorphine could be expanded to treat many of the opioid users who are not in treatment and who are at great risk for opioid overdose, but effective approaches are needed to help individuals with opioid use disorder initiate and remain in office-based buprenorphine treatment. Investigators propose to develop and pilot test a novel intervention that will combine video-based directly observed therapy and incentives to promote buprenorphine treatment engagement and adherence in out-... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/06/2022
Locations: Center for Learning and Health, Baltimore, Maryland
Conditions: Opioid-use Disorder
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Peri-neural Electrical Dry Needling Migraine Treatment Study
NCT04252391
Recruiting
This study seeks to determine the effectiveness of a specific treatment protocol using dry needling with perineural electrical stimulation in comparison to standard treatment in physical therapy for patients with migraine headaches. This will be a randomized cross-over study in which participants will be in the first arm of the study, have a washout period, then cross over to the other arm of the study.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/06/2022
Locations: Ascension Rehabilitation Services, Milwaukee, Wisconsin
Conditions: Migraine Headache
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Enhancing Analgesia in Chronic Pain Through Exercise
NCT04862871
Recruiting
Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies. To date, experiencing a painful stimulus has been known to disrupt motor activity in an attempt to minimize injury. However, physical activity, even when it increases ongoing pain initially, has been shown to significantly reduce pain symptoms eventually through neuromodulation. In both acute and chronic pain cohorts, exercise protocols and neuromodulatio... Read More
Gender:
All
Ages:
Between 10 years and 24 years
Trial Updated:
05/06/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pain, Chronic Widespread Pain, Fibromyalgia
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