U-POEM vs CO2-POEM
NCT06918730
Recruiting
Multicenter randomized trial comparing post-procedural pain intensity after Per-Oral endoscopic myotomy (POEM) between two types of standard of care insufflation methods (CO2 vs Underwater). POEM is routinely performed under carbon dioxide insufflation (CO2-POEM) as this gas is more rapidly absorbed than air, which has been shown to reduce gas-related complications. Water immersion for luminal distension of the GI tract as opposed to carbon dioxide insufflation has been shown to be associated... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: AdventHealth Orlando, Orlando, Florida
Conditions: Esophageal Motility Disorders
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Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+
NCT06919328
Recruiting
This study evaluates the subjective effects of injection administration of NR on healthy adult populations.
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
04/07/2025
Locations: Nutraceuticals Research Institute, Huntsville, Alabama
Conditions: Healthy Aging
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A Study of Ivonescimab in People With Endometrial and Cervical Cancers
NCT06925724
Recruiting
The researchers are doing this study to find out if ivonescimab is an effective treatment for people with endometrial cancer (EC) and/or cervical cancer (CC). The researchers will also look at whether the study drug is safe and causes few or mild side effects in participants.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Endometrial Cancer, Cervical Cancer
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A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD
NCT06925867
Recruiting
The goal of this clinical trial is to learn if the addition of frequency filtered music (Safe and Sound Protocol) to daily cognitive processing therapy improves effectiveness for reducing PTSD symptoms. The main questions it aims to answer are: * Does the addition of frequency filtered music reduce PTSD symptoms for patients receiving cognitive processing therapy for PTSD? * Does the addition of frequency filtered music to cognitive processing therapy improve stress physiology (arousal)? * Does... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: The Ohio State University, Columbus, Ohio +1 locations
Conditions: PTSD - Post Traumatic Stress Disorder
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Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011
NCT06925919
Recruiting
Phase 1 randomized, double-blind, placebo-controlled trial to evaluate safety, tolerability, pharmacokinetics (PK) and immunogenicity of IDB-011 following intramuscular (IM )administration of single ascending doses to healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Cypress, California
Conditions: Rift Valley Fever
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Evaluation of the Safety, Tolerability and Pharmacokinetics of AH-001 Following Topical Single and Multiple Ascending Dose Administration
NCT06927960
Recruiting
The goal of this clinical trial is to assess the safety of the AH-001 drug substance at concentrations of 0.2%, 0.5%, 1%, and 2% in healthy volunteers and male subjects with androgenetic alopecia (AGA). Primary objective: * To evaluate the safety, tolerability, and pharmacokinetics profiles of a single ascending dose (SAD) of AH-001 in healthy volunteers. * To evaluate the safety, tolerability, and pharmacokinetics profiles of multiple ascending doses (MAD) of AH-001 in male subjects with andr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Inc., Los Angeles, California
Conditions: Androgenetic Alopecia
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This Study Explores Whether Adding Natural Elements Like Plants and Sunlight to Indoor Gyms Makes Exercise Feel Easier, More Enjoyable, and Improves Performance. By Comparing Workouts in Nature-inspired and Plain Gym Settings, it Aims to Find Better Ways to Design Fitness Spaces in Cities.
NCT06928311
Recruiting
The goal of this observational study is to examine whether exercising in a biophilic environment - a space designed to include natural elements like real plants, simulated sunlight, nature sounds, and outdoor views - can improve exercise performance and enjoyment compared to a standard indoor gym environment in male college students age 18-25 who have regularly exercised prior. The main question it aims to answer is: "Can biophilic design enhance the physical and mental benefits of indoor exerc... Read More
Gender:
MALE
Ages:
Between 18 years and 25 years
Trial Updated:
04/07/2025
Locations: Colorado State University Cardio Room (Moby Arena 134), Fort Collins, Colorado
Conditions: Biophilic Environmental Design, Traditional Exercise Design
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Data Collection Protocol for the Development of CHLOE-OQ, an AI Model for Assessing Oocytes Quality.
NCT06928337
Recruiting
This data collection protocol is aimed to allow the reliable and robust development (training, verification, and validations) of CHLOE technology-based applications as well as improve the machine learning stage of released devices/applications. Additionally, a simulated use assessments will be conducted to ensure the correct and easy use of the CHLOE applications.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: The World Egg and Sperm Bank, Scottsdale, Arizona
Conditions: Fertility Disorders
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Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
NCT06928467
Recruiting
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. The overarching goal of this project is to improve education and support for caregivers of persons living with dementia so that they can take better care of themselves and also their person living with dementia. Building Better Caregivers workshop i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: University of California, San Francisco, San Francisco, California +1 locations
Conditions: Family Caregivers, Dementia, Self-management, Depression, Internet-based Intervention
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Effects of Natural Sourdough Fermentation Duration and Acid Development on Postprandial Blood Glucose in Prediabetic Adults
NCT06925451
Recruiting
The primary intervention for management of prediabetes is lifestyle changes. Eating healthier and increasing physical activity was found to slow the progression of prediabetes into diabetes, reduce the risk of other diseases like cardiovascular disease and hypertension, and have a lasting impact even after the intervention is discontinued. Studies found that increasing the intake of fiber, pre- and probiotics, and fermented foods have been linked to improved glycemic biomarkers. The goal of this... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/06/2025
Locations: 850 PBC, Phoenix, Arizona
Conditions: Insulin Resistance
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A Study to Test Radium-223 With Docetaxel in Patients With Prostate Cancer
NCT03574571
Recruiting
The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetaxel alone. Earlier studies helped show that the combination is safe, but the combination has not been proven to work better than either drug alone. The goal of this study is to find out if combining docetaxel and radium-223 is better than giving either drug by itself.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +70 locations
Conditions: Prostate Cancer
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Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS
NCT05350748
Recruiting
Background: Myelodysplastic syndromes (MDS) occur when the cells that make blood cells are abnormal. There are limited treatment options for MDS. Researchers want to learn more through this natural history study so they can develop better treatments. Objective: To study the natural course of MDS and MDS/myeloproliferative neoplasms (MPN) and collect biological samples that can help researchers understand the disease. Eligibility: People with suspected or confirmed MDS or MDS/MPN. Healthy do... Read More
Gender:
ALL
Ages:
Between 1 day and 120 years
Trial Updated:
04/04/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Myelodysplastic Syndromes
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