A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced.
NCT04416321
Recruiting
The purpose of this trial is to collect clinical outcomes including radiographic and CT outcomes in patients who undergo spinal fusion using the Keos Lumbar Interbody Fusion Device.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Neurosurgical Associates of Lancaster, Lancaster, Pennsylvania
Conditions: Degenerative Disc Disease, Spondylolisthesis, Retrolisthesis
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Biomarker of Diabetic Retinopathy
NCT05079399
Recruiting
Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional. This can lead to an improper supply of oxygen and nutrients to the retinal tissue, or it may trigger the formation of new blood vessels in response to the oxygen/nutrient deficiency. Ultimately affecting the normal vision. There is no known marker that will provide information on the health status of retinal blood vessels. Using highly specialized cell... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Spring Mill Clinic, Carmel,, Indiana +2 locations
Conditions: Diabetic Retinopathy
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Comparing Two Ways to Manage Head and Neck Lymphedema
NCT05182229
Recruiting
This randomized clinical trial aims to compare clinic-based CDT and home-based (a hybrid model) CDT on changes in the severity of lymphedema, symptom burden, functional status, and healthcare utilization in HNC survivors with lymphedema.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Jefferson Cherry Hospital Jefferson Health, Cherry Hill, New Jersey +5 locations
Conditions: Head and Neck Cancer, Lymphedema
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A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
NCT05362773
Recruiting
CP-MGD024-01 is a Phase 1, open-label, multi-center study of MGD024 as a single agent in participants with select blood cancers that have not responded to treatment with standard therapies or who have relapsed after treatment. The study is designed to determine the safety, tolerability, pharmacokinetics (affect of the body on the drug), pharmacodynamic (affect of the drug on the body), immunogenicity (development of antibodies against the drug), and preliminary anti-cancer effect of MGD024. Par... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Colorado Blood Cancer Network, Denver, Colorado +6 locations
Conditions: Leukemia, Acute Myeloid, Myelodysplastic Syndromes, Classical Hodgkin Lymphoma, Leukemia, B-cell, Leukemia, Hairy Cell, Mastocytosis, Aggressive Systemic, Blastic Plasmacytoid Dendritic Cell Neoplasm, Chronic Myeloid Leukemia
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Exercise in Metastatic Breast Cancer: EMBody
NCT05468034
Recruiting
The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance training exercise for 16 weeks in this population will significantly improve 1) cardiorespiratory fitness, functional status, and sarcopenia (low muscle mass), all established predictors of survival, and 2)... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Yale Cancer Center, New Haven, Connecticut +5 locations
Conditions: Breast Cancer, Indolent Metastatic Breast Cancer
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Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
NCT05552053
Recruiting
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs. This rate doubles for those with adverse perinatal outcomes (APO) and triples in Black women. Recent research points to racism as one significant source of these health disparities. Cultural adaptations to improve communication with providers decrease rates of depression in minority patients as well as im... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
04/29/2025
Locations: Cedars Sinai, Los Angeles, California
Conditions: Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk, Depression, Depression, Postpartum, Perinatal Depression, Anxiety, Anxiety in Pregnancy, Stress, Psychological, Racism, Discrimination, Racial, Inflammation
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Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking
NCT05679349
Recruiting
This clinical trial tests how well providing education improves screening for lung cancer in patients with a history of smoking. Screenings may help doctors find lung cancer sooner when it may be easier to treat. Education and counseling may be an effective method to help providers and patients learn about lung cancer screening. Providing education and decision counseling to providers and patients may increase lung cancer screening.
Gender:
ALL
Ages:
Between 50 years and 77 years
Trial Updated:
04/29/2025
Locations: Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Lung Carcinoma, Tobacco-Related Carcinoma
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A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
NCT05836688
Recruiting
This study is a randomized controlled biobehavioral efficacy trial designed to investigate the feasibility and acceptability of a novel intervention, Goal-focused Emotion-Regulation Therapy (GET) aimed at improving distress symptoms, emotion regulation, goal navigation skills, and stress-sensitive biomarkers in young adult testicular cancer patients. Participants will be randomized to receive six sessions of GET or Individual Supportive Listening (ISL) delivered over eight weeks. In addition to... Read More
Gender:
MALE
Ages:
Between 18 years and 39 years
Trial Updated:
04/29/2025
Locations: University of California, Irvine, Irvine, California
Conditions: Testicular Cancer
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Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
NCT05937854
Recruiting
The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, and lung function. Veterans who enroll in the trial will be allocated by chance to either active tadalafil or an i... Read More
Gender:
ALL
Ages:
Between 35 years and 89 years
Trial Updated:
04/29/2025
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +4 locations
Conditions: Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Dyspnea
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A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults
NCT06047444
Recruiting
The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic migraine. A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head, and is often accompanied by feeling or being sick and a sensitivity to bright lights and sound. Chronic migraine is defined as having at least 15 days of headache a month with at least 8 of those days being migraine headache day... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Central Research Associates, Birmingham, Alabama +111 locations
Conditions: Chronic Migraine
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Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform
NCT06099665
Recruiting
This multi-center, prospective, cluster-randomized controlled trial will evaluate Tempus Next automated notifications as an intervention to support identification and evaluation of patients possibly indicated for Valve Intervention (VI). This study will evaluate the impact of Tempus Next's automated notifications on: (1) Transcatheter or surgical procedure for AS or MR; and (2) Clinic visit with at least one member of the Multidisciplinary Heart Team (including time to evaluation) for patients w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Saint Luke's Health System, Kansas City, Missouri +5 locations
Conditions: Aortic Valve Stenosis, Mitral Regurgitation
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Postoperative Respiratory and Activity Monitoring
NCT06239831
Recruiting
This study plans to learn more about specific breathing and activity recommendations for patients after surgery. Participants will be monitored after abdominal surgery to identify what activities help them breathe better and reduce complications after surgery.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/29/2025
Locations: UC Health, Aurora, Colorado
Conditions: Hypoventilation, Hypoxemia, Postoperative Pulmonary Complications
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