Hearing Aids for Veterans With Functional Hearing Difficulties
NCT06117254
Recruiting
Every year, approximately 100,000 Veterans seek help at VA Audiology clinics for hearing and communication difficulties only to learn that they have normal hearing sensitivity. Unfortunately, there are very few established options to improve hearing and listening for these patients. To address this need, audiologists are increasingly prescribing hearing aids set to provide a small amount of amplification. Patients may benefit from the amplification or from modern hearing aid features such as noi... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
04/29/2025
Locations: VA Portland Health Care System, Portland, OR, Portland, Oregon
Conditions: Auditory Processing Disorder
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INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC
NCT06295731
Recruiting
This seamless phase 2/3 randomized controlled study will evaluate the efficacy and safety of the hexavalent OX40 agonist antibody INBRX-106 combined with the anti-PD-1 antibody pembrolizumab versus pembrolizumab (+ placebo in phase 3) as first-line treatment for patients with locally advanced recurrent or metastatic head and neck squamous cell carcinoma (R/M HSNSCC) incurable by local therapies, expressing PD-L1 with a combined proportion score (CPS) ≥20.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: City of Hope Medical Center, Duarte, California +38 locations
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
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Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis.
NCT06364176
Recruiting
The goal of this clinical trial is to test use of losartan in those with cystic fibrosis (CF) on modulator therapy. The main question it aims to answer is if treatment with losartan improves response of the CF transmembrane conductance regulator (CFTR) channel to modulator therapy. Participants will be asked take losartan or placebo for twelve weeks and will have changes in sweat chloride levels measured as a marker of CFTR function.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/29/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Cystic Fibrosis
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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NCT06423430
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
04/29/2025
Locations: University of Alabama at Birmingham - Dept. of Psychiatry, Birmingham, Alabama +21 locations
Conditions: Treatment Resistant Depression
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Exercise as Maintenance Therapy in Advanced Lung Cancer
NCT06513663
Recruiting
The purpose of this study is to examine how a multimodality (having or using a variety of methods to do something) exercise intervention may improve survival, function, and quality of life in participants with advanced lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Indiana University Health Methodist Hospital, Indianapolis, Indiana +2 locations
Conditions: Lung Cancer, Non Small Cell Lung Cancer, Metastatic Lung Cancer
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Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
NCT06597019
Recruiting
This is a pivotal phase III study designed to evaluate safety, tolerability, and efficacy of inclisiran in children (aged 6 to \<12 years) with heterozygous familial hypercholesterolemia (HeFH) and elevated low density lipoprotein cholesterol (LDLC).
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
04/29/2025
Locations: UC San Francisco Medical Center, San Francisco, California +35 locations
Conditions: Familial Hypercholesterolemia - Heterozygous
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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
NCT06692738
Recruiting
The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Research Site, Springdale, Arkansas +283 locations
Conditions: Non-small Cell Lung Cancer
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An Intervention to Reduce Sedentary Behavior for Black Adults With Chronic Kidney Disease
NCT06754280
Recruiting
RESET-CKD is evaluating an intervention to support Black adults with chronic kidney disease (CKD) to reduce their sedentary (e.g., sitting) time. Half of the participants will be randomized to the intervention, where the goal is to support individuals to reduce their sitting time, and the other half will be randomized to an attention control condition that provides CKD-related education not related to sedentary behavior. All participants will be followed for 12 weeks.
Gender:
ALL
Ages:
Between 35 years and 80 years
Trial Updated:
04/29/2025
Locations: UI Health/University of Illinois Chicago, Chicago, Illinois
Conditions: Chronic Kidney Disease(CKD)
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Health Without Barriers/Salud Sin Barreras- Northern Colorado
NCT06822387
Recruiting
The overarching goal of this work is to address the limited access to evidence-based health behavior and lifestyle interventions for youth and families most impacted by preventable chronic diseases, including obesity and type 2 diabetes. In the current project, we implement a small single-arm pilot and feasibility trial of Health Without Barriers/Salud Sin Barreras (HWB/SSB), a culturally-adapted, whole-family intensive health behavior and lifestyle intervention to 11-19-year-old adolescents and... Read More
Gender:
ALL
Ages:
11 years and above
Trial Updated:
04/29/2025
Locations: Colorado State University, Fort Collins, Colorado
Conditions: Lifestyle Risk Reduction, Adolescent Health, Family Health, Cardio-metabolic Health, Mental Health, Wellness Program, Type 2 Diabetes, Obesity, Adolescent
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Implementation Strategies for Self-Measured Blood Pressure Monitoring in Racially and Ethnically Diverse Populations
NCT06871462
Recruiting
This clinical trial aims to assess the impact of patient-focused and clinical-focused implementation strategies on blood pressure control. The investigators will assess the costs of these strategies and how effective they were at safely and equitably increasing home blood pressure monitoring.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Zuckerberg San Francisco Hospital, San Francisco, California
Conditions: Blood Pressure Monitoring, Home, Hypertension
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DMD Voice: Qualitative Interviews With Patients and Caregivers
NCT06925269
Recruiting
The purpose of this study is to understand DMD functional losses or abilities and their association with independence and quality of life from the perspective of individuals with DMD and/or and their caregivers. This is a qualitative interview study in which individuals with DMD and/or their caregivers will be asked to participate in a semi-structured, approximately 60- minute interview. Interviews will focus on functional abilities and independence. Caregivers and boys with DMD will be intervi... Read More
Gender:
MALE
Ages:
10 years and above
Trial Updated:
04/29/2025
Locations: Red Nucleus, Yardley, Pennsylvania
Conditions: Duchenne Muscular Dystrophy (DMD)
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Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment
NCT06960837
Recruiting
This study is a prospective cohort study implementing a point-of-care ultrasound (POCUS) simulation case-based workshop in emergency (EM) physicians at different training levels as an educational and competency-based assessment tool. The investigators incorporate elements of Miller's pyramid (second and third levels of "knows how" and "shows how") and the latter part of Kern's six step model framework for curriculum development (intervention implementation and student assessment, program evaluat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: Point-of-care Ultrasound, Simulation Training, Medical Education in Emergency Ultrasound
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