A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease
NCT06881836
Recruiting
This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess safety, tolerability, pharmacokinetics, and efficacy of ONO-2020 in participants with mild to moderate Alzheimer's disease (AD). This study aims to determine whether administering ONO-2020, an epigenetic regulator, may improve cognitive functions like memory and cognition in individuals with Alzheimer's disease dementia.
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
04/29/2025
Locations: Sandhill Research, LLC d/b/a Accel Research Sites - NeuroStudies CRU, Decatur, Georgia +11 locations
Conditions: Alzheimer Disease
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Natural Product System and Lifestyle Modification
NCT06931977
Recruiting
The goal of this clinical trial is to learn whether four dietary supplements and lifestyle changes can affect gene expression and blood markers in healthy volunteers. The main questions it aims to answer are: 1. How does daily ingestion of dietary supplements affect gene expression and hsCRP and vitamin D levels measured in blood? 2. How does daily ingestion of dietary supplements affect anthropometric measurements, sleep and physical activity, and gut microbiome composition? 3. How does daily... Read More
Gender:
ALL
Ages:
Between 30 years and 55 years
Trial Updated:
04/29/2025
Locations: doTERRA International, Pleasant Grove, Utah
Conditions: Healthy
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Early-Stage Partner in Care Living Alone Plus
NCT06962111
Recruiting
EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being, manage challenges, and plan for the future. Researchers will gather feedback from individuals about their experience to continue to improve programs for early-stage memory loss.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/29/2025
Locations: Arizona State University, Phoenix, Arizona
Conditions: Dementia, Mild Cognitive Impairment (MCI), Alzheimer Disease
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Viral Infections in Healthy and Immunocompromised Hosts
NCT01306084
Recruiting
Background: - Viral infections are an important cause of illness and death in hospitalized patients as well as outpatients. New strains of viruses may appear and infect both healthy people and those with weak immune systems. A better understanding of these new virus strains (such as SARS-CoV-2, the virus that causes COVID-19) may help to control and prevent these infections. In particular, some viral infections that are less problematic in healthy persons can be life threatening in persons with... Read More
Gender:
ALL
Ages:
Between 6 months and 120 years
Trial Updated:
04/29/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Anogenital Herpes, COVID-19, Herpes Labialis
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The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).
NCT02998229
Recruiting
The purpose of this study is to assess the safety and effectiveness of the Artisse™ Intrasaccular Device in the treatment of unruptured and ruptured wide-neck bifurcating intracranial aneurysms.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/29/2025
Locations: Baptist Medical Center Jacksonville, Jacksonville, Florida +6 locations
Conditions: Intracranial Aneurysm
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Functional Endoscopic Sinus Surgery Study
NCT03970655
Recruiting
The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus surgery (FESS).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/29/2025
Locations: UF Health of University of Florida, Gainesville, Florida
Conditions: Chronic Rhinosinusitis (Diagnosis)
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A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence
NCT04298606
Recruiting
This early phase I trial studies the side effects of a vaccine called CIMAvax-EGF and to see how well it works in preventing lung cancer from developing in patients at high risk for lung cancer or coming back (recurrence) in stage IB-IIIA non-small cell lung cancer survivors. In many cancers such as lung cancer, there is a protein receptor called EGFR (epidermal growth factor receptor) that is overexpressed within these cancers. Activation of EGFR has shown to lead to tumor growth and developmen... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
04/29/2025
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Chronic Obstructive Pulmonary Disease, Lung Non-Small Cell Carcinoma, Pneumonia, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
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Stress and Congestive Heart Failure
NCT04551560
Recruiting
The purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: St. Francis Hospital, Hartford, Connecticut +1 locations
Conditions: Congestive Heart Failure
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A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI
NCT04825743
Recruiting
This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the ambulance if they meet all eligibility criteria. These subjects will be evaluated by (para)medics who transport the subjects to the participating hospitals in Europe and North America. Hospitals and ambulance services with experience in ambulance studies will be selected. Each subject will receive a single subcutaneous injection containing either za... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Providence Alaska Medical Center, Anchorage, Alaska +44 locations
Conditions: ST-elevation Myocardial Infarction (STEMI)
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Patient-Specific Computational Walking Models in Improving Surgical and Rehabilitation Treatment in Patients With Pelvic Sarcomas
NCT05054335
Recruiting
This trial studies the development of patient-specific computational walking models to improve the surgical planning and rehabilitation treatment of patients with pelvic sarcomas. Every pelvis and pelvic sarcoma are different, and the orthopedic oncologist faces significant challenges when removing a tumor from the complex anatomy of the pelvis. These challenges make it difficult to achieve excellent oncological and functional outcomes together. Computational walking models may be used to predic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Pelvic Sarcoma
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Evolut™ EXPAND TAVR II Pivotal Trial
NCT05149755
Recruiting
Obtain safety and effectiveness data to support indication expansion for the Medtronic TAVR System to include patients with moderate, AS.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/29/2025
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +98 locations
Conditions: Moderate Aortic Valve Stenosis
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Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis
NCT05333471
Recruiting
Background: Chronic granulomatous disease (CGD) weakens the body's defense against germs. CGD can also damage the colon. It can cause inflammation (colitis) that disrupts the good bacteria. Placing good bacteria from donor stool into the intestine of a person with CGD (called fecal microbiota transplantation, or FMT) may help. Objective: To see if FMT can reduce inflammation in the colon. Eligibility: People aged 10-60 who have CGD and colitis, and the treatments they have tried are not hel... Read More
Gender:
ALL
Ages:
Between 10 years and 60 years
Trial Updated:
04/29/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Chronic Granulomatous Disease-associated Colitis
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