Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
NCT07044323
Recruiting
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/07/2025
Locations: Jefferson Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania +2 locations
Conditions: Phantom Pain Following Amputation of Lower Limb, Amputation
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Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
NCT07108166
Recruiting
The purpose of this randomized study is to demonstrate direct clinical benefit, i.e., observed benefits in how humans with COPD feel in terms of symptoms (e.g., cough frequency, shortness of breath, and other respiratory symptoms) and function (e.g., lung function, and six-minute walking test \[6MWT\]) after switching to THS compared to continuing to smoking cigarettes.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/07/2025
Locations: Florida International Medical Research, Coral Gables, Florida +63 locations
Conditions: COPD, Smoking, Tobacco Use
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Study to Access the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis
NCT07039916
Recruiting
This is a 26-week study to assess the efficacy, safety and tolerability of IMVT-1402 in adult participants with mild to severe generalized myasthenia gravis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/07/2025
Locations: Site Number - 1017, Phoenix, Arizona +13 locations
Conditions: Generalized Myasthenia Gravis
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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC
NCT06627647
Recruiting
The purpose of ARTEMIDE-Lung03 is to evaluate the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line treatment of patients with non-squamous mNSCLC whose tumors express PD-L1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: Research Site, Mobile, Alabama +275 locations
Conditions: Non-squamous Non-small Cell Lung Cancer
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A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
NCT06617325
Recruiting
The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/07/2025
Locations: Sl0044 50058, Avondale, Arizona +158 locations
Conditions: Systemic Lupus Erythematosus
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Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.
NCT07125079
Recruiting
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) is a condition where high levels of inflammation damage the lung. This is a highly morbid condition with no specific pharmacologic therapies. The investigators posit that ARDS is caused due to an exaggerated activation of immune cells and that blockade of this activation may reduce lung damage/injury and help in ARDS management and possibly recovery. To test this hypothesis, the investigators propose to generate an in vitro i... Read More
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
08/07/2025
Locations: Hospital Of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: ARDS (Acute Respiratory Distress Syndrome)
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Non-Narcotic Pain Control After ACL Reconstruction
NCT06973785
Recruiting
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses taken and documenting the number of patients with no exposure to any narcotics (take zero oxycodone) after undergoing primary knee ACL reconstruction outpatient surgery.
Gender:
ALL
Ages:
Between 15 years and 55 years
Trial Updated:
08/07/2025
Locations: Cleveland Clinic Coral Springs, Coral Springs, Florida +2 locations
Conditions: ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
NCT07013474
Recruiting
This is a Phase 3, randomized, actively controlled, double-blinded, double-dummy, superiority study to evaluate the efficacy and safety of ibuzatrelvir alone and in combination with remdesivir IV compared to remdesivir IV alone for the treatment of symptomatic COVID-19 in severely immunocompromised adult participants who are non-hospitalized or are hospitalized for observation but do not require supplemental oxygen for COVID-19.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: Hope Clinical Research, Inc., Canoga Park, California +25 locations
Conditions: COVID-19 Infection
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Acuvue Oaysis Contact Lens Wearers Being Refit Into P7 Contact Lenses
NCT06955403
Recruiting
Determine the likelihood of successfully refitting a satisfied AOA CL wearers into P7A CLs
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
08/07/2025
Locations: The Southern College of Optometry, Memphis, Tennessee
Conditions: Contact Lens Comfort
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A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)
NCT07011576
Recruiting
This is an open-label multicenter, single-arm Phase II study of Fruquintinib in combination with FOLFIRI (leucovorin calcium (folinic acid), fluorouracil, and irinotecan) in participants with metastatic colorectal cancer (mCRC). The main goals of this study are to: * Evaluate the efficacy of the combination of fruquintinib + FOLFIRI in the 2nd-line mCRC setting * Evaluate the safety of the combination of fruquintinib + FOLFIRI
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: SCRI Oncology Partners, Nashville, Tennessee +1 locations
Conditions: Colon Cancer, Rectal Cancer, Colorectal Cancer, Colorectal Cancer (CRC)
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AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
NCT06991114
Recruiting
A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically modified allogeneic NK cell, in combination with rituximab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: Artiva Clinical Trial Site, Aventura, Florida +5 locations
Conditions: Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA, IIM, Myositis, Scleroderma, Sjogren Syndrome, Sjogrens Disease
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Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
NCT06988176
Recruiting
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery. The main questions it aims to answer are: * Do measures of frailty and muscle strength, taken before surgery, predict complications after surgery? * Can these tests be easily done during a routine pre-surgical visit? Participants will: * Complete brief tests measuring muscle stren... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/07/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Frailty, Sarcopenia, Sarcopenia in Elderly, Post Operative Complications, Nutrition Assessment, Risk Assessment, Elderly (People Aged 65 or More), Hand Strength, Muscle Strength
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