To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation
NCT05881863
Recruiting
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Central Airway Obstruction
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DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
NCT05824585
Recruiting
This study will treat patients with B-NHL who have relapsed, progressed, or were intolerant to systemic therapy progressed following prior therapy. This study will help to understand what type of side effects may occur with the drug treatment. It will also measure the levels of drug in the body and assess its anti-cancer activity as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Research site, New York, New York +4 locations
Conditions: Lymphoma, Non-Hodgkin
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P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies
NCT06014762
Recruiting
Phase 1 study comprised of open-label, dose escalation and expansion cohort study of P-CD19CD20-ALLO1 allogeneic T stem cell memory (Tscm) CAR-T cells in subjects with relapsed/refractory B cell malignancies
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: University of California San Diego, La Jolla, California +12 locations
Conditions: Primary Mediastinal Large B-cell Lymphoma (PMBCL), Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High-grade B-cell Lymphoma, Transformed Follicular Lymphoma (tFL), Follicular Lymphoma Grade 3B, DLBCL, DLBCL - Diffuse Large B Cell Lymphoma, DLBCL Arising From Follicular Lymphoma, DLBCL, Diffused Large B Cell Lymphoma, DLBCL NOS
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Precision Medicine and Physical Function
NCT05877846
Recruiting
The investigators aim to conduct a 12-week, single-arm, pre/post-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary outcomes of physical function and changes in multi-omics patterns, and exploratory outcomes that will allow the team to describe physical function phenotype. The investigators' primary outcomes are the: feasibility of the study procedures (including safety), feasibility... Read More
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
08/06/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Frailty, Weakness, Muscle, Multiple Chronic Conditions
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Clinical Utility of Residual Hearing in the Cochlear Implant Ear
NCT04707885
Recruiting
The current study is a randomized multi-center clinical trial that investigates the role an intraoperative hearing monitoring system (electrocochleography) has on helping to save residual hearing in patients undergoing cochlear implantation (CI).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/06/2025
Locations: Mayo Clinic, Rochester, Minnesota +4 locations
Conditions: Hearing Loss, Sensorineural, Hearing Loss, Hearing Loss, Bilateral
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Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to ER+/HER-2- Breast Cancer
NCT05386108
Recruiting
This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain metastases from estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER-2) negative breast cancer. Phase 1b was designed to select the recommended phase 2 dose and is followed by an ongoing phase 2 evaluation of elacestrant in combination with abemaciclib in patients with active brain metastases from ER-positive, HER-... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Providence Medical Foundation, Fullerton, California +83 locations
Conditions: Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms, Breast Diseases, Central Nervous System Neoplasms, Brain Diseases, Central Nervous System Diseases
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ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies
NCT05653271
Recruiting
ACE1831 is an off-the-shelf, allogeneic gamma delta T (gdT) cell therapy derived from healthy donors, that is under investigation for the treatment of CD20-expressing B-cell malignancies. The ACE1831-001 study is an open-label, Phase I, first-in-human (FIH) study that aims to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and efficacy of ACE1831 in patients with CD20-expressing Non-Hodgkin lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: AdventHealth Orlando, Orlando, Florida +12 locations
Conditions: B-cell Lymphoma, Non Hodgkin Lymphoma, DLBCL, Primary Mediastinal Large B Cell Lymphoma, Marginal Zone Lymphoma, Follicular Lymphoma, Burkitt Lymphoma, High-grade B-cell Lymphoma
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Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine
NCT06003036
Recruiting
In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that a... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/06/2025
Locations: UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder
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A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT06161025
Recruiting
This study will evaluate the safety and efficacy of R-DXd therapy in participants with ovarian, peritoneal, or fallopian tube cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Alaska Women's Cancer Care, Anchorage, Alaska +114 locations
Conditions: Solid Cancer
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Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)
NCT05355272
Recruiting
The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD). The main questions the study aims to answer are: 1. Is growth hormone effective at reducing fat in the trunk of the body and symptoms of GWI among veterans with GWI and growth hormone deficiency? 2. Do the results of the study suggest there is merit in pursuing a larger trial to examine the effic... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/06/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, Texas +1 locations
Conditions: Gulf War Syndrome, Adult Growth Hormone Deficiency
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Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
NCT05866419
Recruiting
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA). All enrolled subjects will undergo implantation of the investigational device (ThecaFlex DRx™ System) and will be followed for 12 months after receiving the implant. The 12-month data will be used to assess the primary endpoint support a Pre-Market Approval (PMA) application.
Gender:
ALL
Ages:
3 years and above
Trial Updated:
08/06/2025
Locations: Children's Hospital Orange County, Orange, California +18 locations
Conditions: Spinal Muscular Atrophy, Spine Deformity, Scoliosis
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Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421
Recruiting
The purpose of this study is to establish the safety and preliminary antitumor activity of ORIC-944 as a single agent and in combinations with ARPIs in patients with metastatic prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Rocky Mountain Cancer Center, Colorado Springs, Colorado +26 locations
Conditions: Metastatic Prostate Cancer
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