Obeticholic Acid for Prevention in Barrett's Esophagus
NCT04939051
Recruiting
This phase II trial studies the effect of obeticholic acid in treating patients with Barrett's esophagus. Bile acids present in duodenogastroesophageal reflux contribute to neoplastic progression in Barrett's esophagus. Obeticholic acid has shown anti-cholestatic, anti-inflammatory and anti-fibrotic effects mediated by FXR activation. It down regulates bile acid availability and decreases proinflammatory cytokine production including IL-1beta and TNFalpha in human enterocytes and immune cells. T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Kansas Cancer Center, Kansas City, Kansas +6 locations
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma
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Radiofrequency Ablation of Adenomyosis
NCT05130190
Recruiting
To observe the effects of radiofrequency ablation on adenomyosis through the pathological analysis of treated tissue that has been removed during planned hysterectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Adenomyosis
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Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer
NCT05358704
Recruiting
To evaluate the safety and preliminary efficacy of Preoperative ChemoRadiation and FOLFOXIRI and to Escalate Complete Response for Rectal Cancer patients.Go through laboratory and medical tests to verify eligibility to enter the study, receive the experimental combination of drugs (chemoradiation (capecitabine and radiation) + FOLFOXIRI (Oxaliplatin, leucovorin, irinotecan, and fluorouracil) prior to surgery and undergo laboratory tests and study procedures on specified days during the study per... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: RWJBarnabas Health - Monmouth Medical Center, Lakewood, New Jersey +4 locations
Conditions: Cancer of Rectum
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A Study of SDX-7320 in Combination With Eribulin for People With Breast Cancer
NCT05570253
Recruiting
The researchers are doing this study to find out whether the study drug, SDX-7320, when combined with the standard chemotherapy eribulin, is an effective treatment for people with TNBC and metabolic dysfunction. The researchers will also look at whether the study treatment (SDX-7320 combined with eribulin) is safe and causes few or mild side effects in participants. The researchers will compare this treatment approach to eribulin alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: BAPTIST ALLIANCE - MCI (Data Collection Only), Miami, Florida +9 locations
Conditions: Breast Cancer, Metastatic Triple-Negative Breast Cancer
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Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
NCT05665465
Recruiting
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults. The investigators assess responses to nicotine exposure by giving participants a small amount of nicotine or placebo, and then asking them to answer questionnaires. The investigational drugs used in this study are a nicotine nasal spray (i.e., Nicotrol) and/or a nasal spray placebo (made of common kitchen ingredients, inclu... Read More
Gender:
ALL
Ages:
Between 18 years and 21 years
Trial Updated:
04/11/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
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A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Non-Ambulatory and Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)
NCT05881408
Recruiting
The study will evaluate the safety and efficacy of delandistrogene moxeparvovec gene transfer therapy in non-ambulatory and ambulatory males with DMD. This is a randomized, double-blind, placebo-controlled 2-part study. Participants will be in the study for approximately 128 weeks. All participants will have the opportunity to receive intravenous (IV) delandistrogene moxeparvovec in either Part 1 or Part 2.
Gender:
MALE
Ages:
All
Trial Updated:
04/11/2025
Locations: Arkansas Children's Hospital, Little Rock, Arkansas +42 locations
Conditions: Duchenne Muscular Dystrophy
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A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer
NCT05984602
Recruiting
The goal of this Single Arm Phase Ib clinical trial is to test standard of care chemotherapy and anti PD1 and IL1b to evaluate the safety and preliminary toxicity of this quadruplet regimen prior to resection in patients with pancreatic cancer. The main objectives it aims to answer are to: * Determine the recommended Phase II dose regimen of canakinumab and tislelizumab in combination with gemcitabine and nab-paclitaxel in patients with localized pancreatic ductal adenocarcinoma. * Estimate the... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/11/2025
Locations: Ambulatory Care Center, New York, New York +2 locations
Conditions: Pancreatic Cancer
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An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing Head and Neck Cancer Surgery
NCT06079697
Recruiting
This clinical trial evaluates a prehabilitation exercise intervention for improving mobility and recovery outcomes in patients undergoing surgery for head and neck cancer. Prehabilitation focuses on optimizing health before surgery in order to improve outcomes after surgery. Prehabilitation may include aspects of nutrition, exercise, mental health, or a combination of these. Exercise has been proven to improve anxiety, depression, fatigue, health related quality of life, and physical function am... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/11/2025
Locations: OHSU Knight Cancer Institute, Portland, Oregon
Conditions: Head and Neck Carcinoma
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An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
NCT06278207
Recruiting
This is an observational study, in which data from people in Japan and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their doctors. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys' ability to work properly. In people wit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Many Locations, Multiple Locations, New Jersey +2 locations
Conditions: Chronic Kidney Disease, Type 2 Diabetes Mellitus
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The Effects of Palmar Cooling on Repeated Sprinting Ability
NCT06356142
Recruiting
Repeated sprinting ability is key for athletic performance in a variety of sport settings. Significant degradations in work output (i.e. fatigue) have been shown to develop after just one sprinting bout1. This pilot study aims to investigate the effects that noninvasive transient temperature manipulation has on an individual's ability to perform repeated sprints. The investigators aim to enroll 90 healthy individuals, 18-30 years of age. Participants will be randomized into two groups (Group A,... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/11/2025
Locations: University of Mississippi Medical Center, Jackson, Mississippi
Conditions: Exercise Induced Fatigue
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Speech Motor Learning and Retention (Aim 1)
NCT06467305
Recruiting
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic reso... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/11/2025
Locations: Yale Child Study Center, New Haven, Connecticut
Conditions: Speech
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A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)
NCT06510816
Recruiting
The primary purpose of the study is to determine if IVT injections of ANX007 every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/11/2025
Locations: Retina Macula Institute of Arizona, Scottsdale, Arizona +104 locations
Conditions: Geographic Atrophy
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