Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia
NCT06493825
Recruiting
Children with "bothersome" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT). CBT resources are expensive and scarce for the pediatric population. Immersive virtual reality (IVR) has been shown in the adult population to be a proxy for CBT for several mental health disorders. There is sufficient published evidence that IVR is useful in treating adults with anxiety and depr... Read More
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
04/11/2025
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Tinnitus, Misophonia
Register for Updates
Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)
NCT06556654
Recruiting
The GORE Tissue Reinforcement for Breast Reconstruction (TRBR) research study will look at breast reconstruction during mastectomy procedures. There will be two arms in this study, a Treatment Arm, where data will be collected for a new medical device called the Tissue Reinforcement for Breast Reconstruction (TRBR) Device and a Control Arm where data will be collected from subjects who have previously had surgery and received no additional tissue reinforcement in their breast reconstruction surg... Read More
Gender:
FEMALE
Ages:
22 years and above
Trial Updated:
04/11/2025
Locations: University of Mississippi, Jackson, Mississippi +1 locations
Conditions: Breast Reconstruction Surgery
Register for Updates
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
NCT06631287
Recruiting
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomarkers of inflammation and viral measures, in participants with Long COVID.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of California San Francisco, San Francisco, California +2 locations
Conditions: Long COVID, Sars-CoV-2 Infection, Coronavirus Infections, COVID-19
Register for Updates
The Minimalist Trial-2
NCT06702033
Recruiting
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer. Oropharynx SCC (OPSCC) is a common sub-type of HNSCC. Each year, 16,000 new cases of OPSCC are diagnosed in the USA. Most cases of OPSCC (\>90%) are caused by the human papillomavirus (HPV) and are often cured with current therapy. However, patients treated with surgery followed by postoperative adjuvant chemotherapy and radiation therapy (POA(C)RT) still experience substantial morbidity. In this highly curable disea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: HPV-Related Oropharynx Squamous Cell Carcinoma
Register for Updates
Efficacy of Synchronous, Virtual Cognitive Behavioral Therapy for Insomnia Across Phases of Cancer Survivorship
NCT06807086
Recruiting
This project is a single center, prospective randomized controlled trial (N=198) primarily evaluating the efficacy of the Survivorship Sleep Program vs. Enhanced Usual Care on insomnia severity among cancer survivors. The investigators will also examine secondary outcomes associated with cancer-related insomnia including subjective and objective sleep measures (i.e., sleep diaries, actigraphy), emotional distress, fatigue, and use of sleep medications. Notably, most CBT-I trials with cancer sur... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/11/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Insomnia Chronic
Register for Updates
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
NCT06874374
Recruiting
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects on symptoms of depression in people with major depressive disorder.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/11/2025
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Register for Updates
Effect of Tao Calligraphy Meditation and Energized Water on Depression
NCT06934330
Recruiting
The goal of this controlled randomized clinical study is to learn if a Tao Calligraphy Mindfulness and Energized water Practice works to improve Unipolar Depression. The main questions it aims to answer are: * Does Tao Calligraphy Mindfulness practice and drinking Energized water improve the subjective symptoms of Unipolar Depression in adults? * Does Tao Calligraphy Mindfulness practice and drinking Energized water improve the clinical symptoms and signs of Unipolar Depression in adults? * Wil... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
04/11/2025
Locations: Satori Family Wellness Center, Kahului, Hawaii
Conditions: Unipolar Depression
Register for Updates
Fecal Microbiota Transplantation for C Diff Infection
NCT01905709
Recruiting
The objective of this study is to provide treatment with Fecal Microbiota Transplantation (FMT) to patients with recurrent or refractory Clostridium difficile infection (CDI). It has been shown that good bacteria (like that found in the stool from a healthy donor) attack Clostridium difficile in multiple ways: they make substances that kill Clostridium difficile - and they attach to the surface of the colon lining, which prevents the Clostridium difficile toxin (poison) from attaching. FMT invo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Englewood Hospital and Medical Center, Englewood, New Jersey
Conditions: Clostridium Difficile Infection
Register for Updates
Mevrometostat Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977
Recruiting
A Phase 1 Dose Escalation and Expanded Cohort Study Of PF-06821497 (Mevrometostat) in Adult Patients With Relapsed/Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) And Follicular Lymphoma (FL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Urological Associates of Southern Arizona, P.C ., Tucson, Arizona +88 locations
Conditions: Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL), Metastatic Castration Resistant Prostate Cancer (mCRPC)
Register for Updates
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
NCT03854344
Recruiting
Donor site pain study comparing post-operative donor site pain and opioid consumption after use of Lidocaine, Liposomal Bupivicaine or regional nerve block for split thickness skin graft harvesting in patients with less than 20% TBSA burn wounds and less than %5 Deep partial or full thickness burn wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: The University of Kansas Health System, Kansas City, Kansas
Conditions: Pain, Postoperative, Burns
Register for Updates
Phase II Panitumumab-IRDye800 in Head & Neck Cancer
NCT04511078
Recruiting
The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this drug.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Head and Neck Cancer
Register for Updates
The Stimulation To Induce Mothers Study
NCT05079841
Recruiting
The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term. The central hypothesis is that intrapartum nipple stimulation to induce labor increases spontaneous vaginal delivery, improves patient-centered outcomes such as childbirth satisfaction, labor agentry, and pain scores, and reduces adverse neonatal and maternal outcomes in nulliparous women. The inve... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut +2 locations
Conditions: Oxytocin, Labor Pain, Induction of Labor Affected Fetus / Newborn, Physiologic Effects of Drugs
Register for Updates