A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP
Recruiting
The principal aim of this study is to obtain safety and tolerability data when MRT-8102 is administered orally as single and multiple doses to healthy participants and participants at cardiovascular risk with elevated CRP. This information, together with the pharmacokinetic (PK) data, will help establish the dose and dosing regimen suitable for future studies. The study drug, MRT-8102, is experimental. This is the first study in which MRT-8102 will be given to humans. Part 1: Healthy participa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/05/2025
Locations: ICON Clinical Research, Lenexa, Kansas
Conditions: Healthy Volunteers, Elevated CRP
A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
Recruiting
The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to t... Read More
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
08/05/2025
Locations: Orange County Research Center, Lake Forest, California +4 locations
Conditions: Streptococcus Pneumoniae
Telehealth to Improve Quality of Life in Persons Living in Rural Texas
Recruiting
The overarching goal of this project is to evaluate a current evidence-based practice, Cognitive Behavioral Therapy, for mental health conditions against Cognitive Behavioral Therapy plus two check-in calls a week for adults living in rural Texas.
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
08/05/2025
Locations: Garrison Institute on Aging, Lubbock, Texas
Conditions: Mental Health Issue, Quality of Life
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Recruiting
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
08/05/2025
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Preterm PROM (Pregnancy)
Yeast Mannans and Stool Frequency
Recruiting
Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Se... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2025
Locations: Department of Food Science and Human Nutrition, Gainesville, Florida
Conditions: Defecation Frequency
A Study of BG-C477 in Participants With Advanced Solid Tumors
Recruiting
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-C477 alone and in combination with anticancer agents in participants with selected advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: City of Hope National Medical Center, Duarte, California +12 locations
Conditions: Advanced Solid Tumors
REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome
Recruiting
The purpose of this study is to evaluate the efficacy and safety of ION582 in children and adults with Angelman syndrome caused by a deletion or mutation of the UBE3A gene.
Gender:
ALL
Ages:
Between 2 years and 50 years
Trial Updated:
08/05/2025
Locations: Rady Children's Hospital, San Diego, California +2 locations
Conditions: Angelman Syndrome
Circadian Mechanisms, Glucose, and CV Risks in T1D
Recruiting
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance t... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/05/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Type 1 Diabetes (T1D)
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Recruiting
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Parkinson Disease
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
Recruiting
This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +212 locations
Conditions: Metastatic Castration-Resistant Prostate Cancer
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
Recruiting
Pfizer MEVPRO-1 (C2321014) is a randomized, open-label, multi-center clinical trial evaluating whether combining the study medicine (PF-06821497) with enzalutamide is safe and effective compared to physician's choice of either second-line androgen receptor (AR) directed therapy with enzalutamide or docetaxel (chemotherapy) for treating metastatic castration-resistant prostate cancer (mCRPC) after progression on prior abiraterone acetate treatment. The primary objective of this clinical trial is... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Urology Centers of Alabama, Homewood, Alabama +220 locations
Conditions: Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Recruiting
The objective of this study is to pilot a multifaceted, optimized intervention for metabolic syndrome (MetS) in emergency department patients to establish feasibility. Participants (n=20) will be randomized to intervention or control (usual care). The composite intervention will include an educational video outlining the adverse effects of MetS and the benefit of walking, a written exercise prescription with a defined goal of walking 150 minutes per week, a Fitbit accelerometer device, resources... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Sidney & Lois Eskenazi Hospital, Indianapolis, Indiana
Conditions: Hypertension, Hyperglycemia, Dyslipidemia, Metabolic Syndrome, Obesity &Amp; Overweight, Diabetes, Hyperlipidemia, Emergency Medicine