Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
Recruiting
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Misuse, Opioid
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
Recruiting
The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN. This study consists of a screening, a 4-week dapagliflozin run-in period for participants naïve to SGLT2i at baseline; a 24-month double-blind period in which participants will receive either baxdrostat/dapagliflozin or dapagliflozin; and a 6-week open-label period in which all participants will discontinue baxdrostat/placebo and receive dapagliflozin a... Read More
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/05/2025
Locations: Research Site, Fairhope, Alabama +623 locations
Conditions: Chronic Kidney Disease and Hypertension
Evaluating Clinical Hiatal Hernia Outcomes Using OviTex®
Recruiting
This study will evaluate hiatal hernia recurrence rate and post-operative complications following the use of OviTex Core Resorbable or OviTex 1S Resorbable.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
08/04/2025
Locations: The University of Texas at Austin - Dell Medical School, Austin, Texas
Conditions: Hiatal Hernia
Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers
Recruiting
This phase II trial compares therapeutic plasma exchange followed by enfortumab vedotin and pembrolizumab to standard of care next-line therapy for the treatment of patients with bladder or upper urinary tract cancers that have spread from where they first started (primary site) to other places in the body (metastatic) and that have not responded to previous treatment (refractory). TPE is a process that slowly removes a patient's blood through an intravenous or central line. The blood is sent th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma, Refractory Bladder Urothelial Carcinoma, Refractory Renal Pelvis and Ureter Urothelial Carcinoma, Stage IV Bladder Cancer AJCC v7, Stage IV Renal Pelvis and Ureter Cancer AJCC v7
Speech Understanding and Listening Effort Benefits of Hearing Instruments
Recruiting
The goal of this clinical study is to investigate the benefits of hearing instrument use in adults with hearing loss. The main questions it aims to answer are: Does hearing instrument use improve speech understanding and listening effort amount people with hearing loss? Researchers will compare varying models of hearing instruments to see how speech understanding and listening effort are impacted. Participants will be asked to wearing varying hearing instruments and participate in lab-based ac... Read More
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
08/04/2025
Locations: University of South Florida Auditory Neurosciences & Technology Lab, Tampa, Florida
Conditions: Hearing Loss, Bilateral
A Vaccine Promotion Package (TweenVax) to Improve Adolescent HPV Vaccination, TweenVax Trial
Recruiting
This clinical trial compares the effect of a vaccine promotional intervention, TweenVax, to standard of care vaccination promotion practices on rates of human papillomavirus (HPV) vaccination in adolescents. HPV vaccination has been identified as a priority for cancer prevention and control by the Cancer Moonshot Blue Ribbon Panel, which estimated that increasing HPV vaccination rates can prevent 400,000 HPV-related cancers in the next 5-10 years. The goal is for HPV vaccinations to be completed... Read More
Gender:
ALL
Ages:
9 years and above
Trial Updated:
08/04/2025
Locations: Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Conditions: Human Papillomavirus-Related Carcinoma
A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD
Recruiting
This study is testing the safety, tolerability, pharmacokinetics and pharmacodynamics of GB-0895.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/04/2025
Locations: Alcanza, DeLand, Florida +12 locations
Conditions: Asthma, COPD (Chronic Obstructive Pulmonary Disease)
Assessing Claims of Cannabis as an Anti-cancer Agent (CATA)
Recruiting
The purpose of the study is to find out how cannabis may help control cancer growth by reviewing medical records of patients who report cannabis helped treat their cancer.
Gender:
ALL
Ages:
All
Trial Updated:
08/04/2025
Locations: HealthPartners Institute Cancer Research Center, Saint Louis Park, Minnesota
Conditions: Cancer, Cancer (With or Without Metastasis)
Phase 3, Open-label, Single-dose Study of CSL222 in Adolescent Male Subjects (≥ 12 to < 18 Years of Age) With Severe or Moderately Severe Hemophilia B
Recruiting
This is a phase 3, prospective, open-label, single-arm, single-dose, multicenter study investigating the efficacy, safety, and tolerability of CSL222 (AAV5-hFIXco-Padua) in adolescent male participants with severe or moderately severe hemophilia B.
Gender:
MALE
Ages:
Between 138 months and 206 months
Trial Updated:
08/04/2025
Locations: University of Florida - 84000399, Gainesville, Florida +1 locations
Conditions: Hemophilia B
Inspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval Study
Recruiting
The purpose of this observational clinical study is to provide evaluation of long-term safety and effectiveness in a newly expanded patient population including patients with a higher AHI and a higher BMI.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Colorado ENT & Allergy, Colorado Springs, Colorado +4 locations
Conditions: Obstructive Sleep Apnea (OSA)
Opiophobia in Adults With Advanced Cancer
Recruiting
To explore the barriers and fears related to use of opioids among a population of adult outpatients with advanced cancer who continue to experience pain after receiving a prescription for opioid analgesia and hypothesized associations among opiophobia, anxiety, depression, pain intensity, pain interference, and opioid medication adherence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Conditions: Cancer
Partial-enteral Nutrition Protocol for Crohn's Disease
Recruiting
A novel dietary intervention combining a standardized IBD diet (IBD-AID) with supplementation from a pea protein plant-based oral nutrition supplement (ONS) (Kate Farms Peptide 1.5) to improve protein, calorie, and nutrient intake in adult patients experiencing a Crohn's disease flare starting new immunologic therapy. Additionally, this study will include objective measures of body composition to improve nutrition status assessment and provide a more sensitive measure of intervention efficacy co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Crohn's Disease(CD)