Dose Escalation Study Evaluating Safety of TheraSphere Prostate Cancer (PCa) Device
Recruiting
The VOYAGER Study is an interventional, non-randomized, single-arm, dose escalation trial with the goal of determining the safety of TheraSphere PCa device in patients with clinically localized prostate cancer across US-based centers.
Gender:
MALE
Ages:
50 years and above
Trial Updated:
05/27/2025
Locations: Ronald Reagan UCLA Medical Center (UCLA Health, Los Angeles), Los Angeles, California +4 locations
Conditions: Prostate, Cancer
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
Recruiting
This study will collect information from participants with Primary Biliary Cholangitis (PBC) as they use the drug elafibranor in real world setting. PBC is a progressive rare liver disease in which tubes in the liver called bile ducts are damaged. The liver damage in PBC may lead to scarring (cirrhosis). PBC may also be associated with multiple symptoms. Many participants with PBC may require liver transplant or may die if the disease progresses and a liver transplant is not done. In this stu... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/27/2025
Locations: Southern California Research Center, Coronado, California +35 locations
Conditions: Primary Biliary Cholangitis
Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users
Recruiting
Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users (PRIMULA Lac) is a Post Marketing Requirements (PMR) study designed to fulfill the FDA post-marketing requirements. The study will collect data about the presence of anifrolumab in human breast milk and serum (maternal and infant) among lactating individuals who receive anifrolumab therapeutically.
Gender:
FEMALE
Ages:
Between 18 years and 130 years
Trial Updated:
05/27/2025
Locations: Research Site, Las Vegas, Nevada
Conditions: Systemic Lupus Erythematosus
A Study to Evaluate the Safety and Efficacy of AV-1 Against Dengue Virus 3 (DENV-3) Infection
Recruiting
The goal of this clinical trial is to determine the prophylactic and therapeutic effect of AV-1 in healthy adults using a DENV-3 controlled human infection model (CHIM)
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/27/2025
Locations: Center for Immunization Research (CIR) JHBSPH, Baltimore, Maryland +2 locations
Conditions: DENV-3 Controlled Human Infection Model
Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid
Recruiting
The overall goal of the randomized control trial (RCT) will be to evaluate the efficacy of modifications to a web-based tool for patient decision-making regarding return of genomic results that will more closely focus on rare cancers. Participants will be given access to a web-based decision aid (or a standard control) that guides participants in making decisions about what type of genomic results they would like to receive from testing performed in the PE-CGS study (NCT06340646).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Cholangiocarcinoma, Colorectal Cancer, Multiple Myeloma
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
Recruiting
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.
Gender:
ALL
Ages:
Between 11 years and 75 years
Trial Updated:
05/27/2025
Locations: Cenexel, Englewood, Colorado +38 locations
Conditions: Huntington's Disease
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
Recruiting
The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). The main objectives are to compare the effects of Standard rehabilitation vs. rehabilitation that includes whole body vibration (WBV) or local muscle vibration (LMV) on: * Quadriceps muscle function *... Read More
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
05/27/2025
Locations: MOTION Science Institute, Chapel Hill, North Carolina +1 locations
Conditions: Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
IUD Self-Removal Study
Recruiting
This is a pilot study designed to test the effectiveness of several techniques for intrauterine device (IUD) self-removal and to understand patient preferences regarding IUD self-removal and indicators of success as well as understanding the impacts of IUD self-removal on other clinical care.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/27/2025
Locations: Oregon Health & Science Univeristy, Portland, Oregon
Conditions: IUD
Prenatal Aspirin and Postpartum Vascular Function
Recruiting
Preeclampsia is a pregnancy disorder affecting \~5-10% of pregnancies in the United States. Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be related to blood vessel damage and increased inflammation that occurs during the preeclamptic pregnancy and persists postpartum. Low dose aspirin (LDA; 75-150mg/daily) is currently the most effective... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/27/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Preeclampsia, Microvascular Function
Healthy Communities Through CHW Initiatives
Recruiting
Latino(a)s suffer from poor social determinants of health (SODH) conditions more than non-minority populations, and being a minority is risk factor alone for diabetes. In the proposed study, investigators will assist church members in becoming Community Health Workers (CHWs), train them in diabetes, and to track the ability to address healthcare access and quality barriers using an online platform.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: University of Texas Medical Branch at Galveston, Galveston, Texas
Conditions: Diabetes Mellitus, Type 2, Diabetes Mellitus Risk
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma
Recruiting
The goal of this interventional clinical trial is to provide proof-of-principle data for the biologic activity of defactinib in combination with avutometinib in brain metastases from melanoma, and to define the potential role of the combination with mutant BRAF inhibitors or after BRAF/MEK inhibitors in BRAF V600E/K mutant tumors, in individuals with advanced melanoma who experience the development or progression of brain metastases after treatment with immune checkpoint inhibitors. The main qu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: University of Iowa, Iowa City, Iowa +1 locations
Conditions: Melanoma
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
Recruiting
The purpose of this study is to establish the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) inadequately controlled by non-sedating second generation H1-antihistamines in comparison to placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Allervie Clinical Research - Cullman, Cullman, Alabama +182 locations
Conditions: Chronic Spontaneous Urticaria