Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients
Recruiting
Despite medical and surgical advances, long-term survival in liver transplant (LT) recipients is compromised by an increased risk of cardiovascular disease (CVD) after transplant, the mechanisms of which are still not fully understood. TMAO is an attractive therapeutic target to improve vascular health and diastolic function toward preventing CVD in LT patients. Therefore, the purpose of this study is to better understand the role of TMAO in cardiovascular dysfunction patients with chronic kidne... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Liver Transplant
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)
Recruiting
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) by assessing its safety and tolerability in subjects with OUD.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
03/04/2024
Locations: West Virginia University: Rockefeller Neuroscience Institute, Morgantown, Virginia
Conditions: Opioid-use Disorder
A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men
Recruiting
The goal of this clinical trial is to test a new smartphone-based program designed to help African American men get screened for colorectal cancer (CRC). The main question it aims to answer is: ° Are African American men who complete the smartphone-based program more likely to get screened for colorectal cancer than men who do not? Participants will: Complete a baseline survey asking about their colorectal cancer screening history and their thoughts and beliefs about colorectal cancer and the... Read More
Gender:
Male
Ages:
Between 45 years and 75 years
Trial Updated:
03/04/2024
Locations: ISA Associates, Inc., Alexandria, Virginia
Conditions: Colorectal Cancer
Impact VR: An Emotion Recognition and Regulation Training Program for Youth With CD
Recruiting
Conduct disorder (CD) is one of the most prevalent childhood psychiatric disorders. Unfortunately, there are limited treatments available for CD. The present study aims to test an innovative virtual reality intervention called Impact VR for symptom reduction in a sample of 60 youth with CD.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
03/03/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Conduct Disorder, Conduct Disorders in Children, Conduct Disorders in Adolescence, Callous-Unemotional Traits
Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
Recruiting
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuropathic Pain
Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)™
Recruiting
A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and failures in the presence of liver cirrhosis (Acute-on-Chronic Liver Failure, ACLF) and accumulation of fluid in the abdominal cavity (ascites)
Gender:
All
Ages:
Between 18 years and 69 years
Trial Updated:
02/28/2024
Locations: Richmond VA Medical Center, Richmond, Virginia +12 locations
Conditions: Acute-On-Chronic Liver Failure, Ascites
A Pilot Prospective Clinical Trial Using Remote Monitoring for Cancer Patients Undergoing Outpatient Chemotherapy
Recruiting
A pilot study using remote monitoring technology developed by Locus Health in cancer patients undergoing chemotherapy treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Inova Schar Cancer Institute, Fairfax, Virginia
Conditions: Solid Tumor, Hematological Malignancy
Integration of Neurofunctional Phenotyping Into Investigation of CBT4CBT for AUD
Recruiting
Alcohol use and misuse are prevalent in the United States. Alcohol use disorder (AUD) is the most common substance use disorder. Evidence-based treatments are effective; however, most people with AUD do not receive treatment, and among those who do, responses to treatment modalities vary. Technology provides the opportunity to expand treatment and improve outcomes. Therefore, the overall goal of this project is to incorporate neurofunctional phenotyping into a preliminary investigation of the fe... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Alcohol Abuse, Alcohol Use Disorder
Gaps in Periodontal Care in Cirrhosis
Recruiting
The goal of this observational study is to learn about dental evaluation and periodontal cleaning along with scheduled follow -up on the dental health and overall health of patients with cirrhosis and also to determine what barrier(s) if any exist to improve oral health in this population.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, Virginia +1 locations
Conditions: Cirrhosis, Periodontal Diseases
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Recruiting
TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairment (cognitive and behavioral foremost, along with motor, sensory, and balance), that limits their functional independence and participation, and increases their risk for secondary medical conditions,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Traumatic Brain Injury
Effect of Parenting With Positive Interven on Comm Inclusion for Military Connected and Dependents With Autism
Recruiting
The purpose of this research study is to find out if a training program for parents with military dependent or connected children with autism (ASD) who have challenging behavior will help those children and their families participate in more community activities. The training program, called Parenting with Positive Behavior Interventions, may help military parents learn new tools that will help their children with autism and challenging behavior attend community activities more easily.
Gender:
All
Ages:
Between 5 years and 11 years
Trial Updated:
02/26/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Autism
Epidural Stimulation and Resistance Training After SCI
Recruiting
Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life. A new scientific breakthrough called "lumbosacral epidural stimulation" or "ES" can help people with SCI to stand, step and even walk again. At present, for ES to work, people must train with a specialized treadmill that requires several other qualified personnel to train them, which makes it hard... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/23/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, Virginia
Conditions: Spinal Cord Injuries