Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Young Adults
Recruiting
The purpose of the CliniMACS® TCRαβ-Biotin System and CliniMACS® CD19 is to improve the safety and efficacy of allogeneic HLA-partially matched related or unrelated donors HSCT when no matched donors are available, to treat malignant and nonmalignant disorders for which HSCT is the recommended best available therapy. Initially this device will be used in a single-center, open-label, single-arm, phase II clinical trial to evaluate the efficacy of haploidentical PBSC grafts depleted of TCRα/β+ and... Read More
Gender:
ALL
Ages:
Between 1 month and 60 years
Trial Updated:
05/22/2025
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: Hematologic Diseases
Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry
Recruiting
The objective of this post market, clinical registry is to evaluate the performance of the products of the TVT family of products or vaginal vault or uterine prolapse repair (with laparotomic or laparoscopic approach including robotic assisted) using either Gynemesh PS Mesh or Artisyn Mesh in women undergoing surgery for SUI and POP.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
05/22/2025
Locations: Yale University, New Haven, Connecticut +10 locations
Conditions: Stress Urinary Incontinence, Pelvic Organ Prolapse
A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis
Recruiting
The purpose of this study is to evaluate the pharmacokinetics (PK), efficacy, safety and immunogenicity of ustekinumab and guselkumab in active juvenile psoriatic arthritis (jPsA).
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
05/22/2025
Locations: Childrens Hospital Los Angeles, Los Angeles, California +49 locations
Conditions: Arthritis, Juvenile
A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma
Recruiting
This is a Phase Ib multicenter, open-label study of JNJ-90014496, an autologous bi-specific chimeric antigen receptor (CAR) T-cell therapy, targeting both cluster of differentiation (CD) CD19 and CD20 for the treatment of adult participants with B-Cell non-Hodgkin lymphoma (B-NHL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: City of Hope, Duarte, California +27 locations
Conditions: Lymphoma, Non-Hodgkin, Lymphoma, B-Cell
The Patient and Family Centered I-PASS LISTEN Study: Language, Inclusion, Safety, and Teamwork for Equity Now
Recruiting
In 2014, a team of parents, nurses, and physicians created Patient and Family Centered I-PASS (PFC I-PASS), a bundle of communication interventions to improve the quality of information exchange between physicians, nurses, and families, and to better integrate families into all aspects of daily decision making in hospitals. PFC I-PASS changed how doctors and nurses talk to patients and families on rounds when they're admitted to the hospital. (Rounds are when a team of doctors visit patients eve... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +7 locations
Conditions: Communication
Personalizing Treatment Delivery
Recruiting
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society. The proposed research will use digital technology to examine person-specific risk factors predicting problematic alcohol use in individuals vulnerable to anxiety and anxiety-related disorders and will use this information to design a personalized intervention for individuals seeking psychological treatment. Results from this research will integra... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/22/2025
Locations: Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey
Conditions: Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
Recruiting
Proton pump inhibitors (PPIs) are widely used for the control of gastric ulcer-gastritis, erosive esophagitis (gastroesophageal reflux disease), peptic ulcer disease (duodenal ulcer), and heartburn. Despite their efficacy, their use has been implicated in possibly causing fragility fractures (osteoporosis), hypomagnesemia (magnesium deficiency) and increased risk of chronic kidney disease (CKD). The current trial represents the investigators ongoing effort to discern whether these complications... Read More
Gender:
ALL
Ages:
Between 21 years and 99 years
Trial Updated:
05/22/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas +1 locations
Conditions: Osteoporosis, Hypomagnesemia
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Cardurion Investigative Site, Birmingham, Alabama +83 locations
Conditions: Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
Recruiting
Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining treatment strategy. Despite this, there are currently no reliable biomarkers established to detect LNM in ICC. This study seeks to develop a liquid biopsy assay that can accurately detect LNM before treatment in ICC patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: City of Hope Medical Center, Duarte, California +3 locations
Conditions: Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic, Cholangiocarcinoma Resectable, Cholangiocarcinoma; Liver
Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)
Recruiting
The GORE Tissue Reinforcement for Breast Reconstruction (TRBR) research study will look at breast reconstruction during mastectomy procedures. There will be two arms in this study, a Treatment Arm, where data will be collected for a new medical device called the Tissue Reinforcement for Breast Reconstruction (TRBR) Device and a Control Arm where data will be collected from subjects who have previously had surgery and received no additional tissue reinforcement in their breast reconstruction surg... Read More
Gender:
FEMALE
Ages:
22 years and above
Trial Updated:
05/22/2025
Locations: University of Mississippi, Jackson, Mississippi +1 locations
Conditions: Breast Reconstruction Surgery
A Study of JNJ-89402638 for Metastatic Colorectal Cancer
Recruiting
The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) of JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: University of Colorado Denver Anschultz Medical Campus, Aurora, Colorado +7 locations
Conditions: Unresectable Metastatic Colorectal Cancer
Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis
Recruiting
The AURORA Study is evaluating the safety, tolerability, and efficacy of an investigational mRNA CAR T-cell therapy known as Descartes-08 in adults with acetylcholine receptor autoantibody -positive generalized myasthenia gravis. Part 1 of the study will last around 6 months. For eligible participants, Part 2 will last around 8 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: A13, Carlsbad, California
Conditions: Myasthaenia Gravis