A Phase 2 Basket Study of Vosoritide in Children With Turner Syndrome, SHOX Deficiency and Noonan Syndrome With an Inadequate Response to Human Growth Hormone
NCT06668805
Recruiting
The purpose of this basket study in children with Turner syndrome, SHOX deficiency, and Noonan syndrome is to evaluate the effect of 3 doses of vosoritide versus hGH on growth as measured by AGV after 6 months of treatment. The long-term efficacy and safety of vosoritide at the therapeutic dose will be evaluated up to FAH.
Gender:
ALL
Ages:
Between 3 years and 11 years
Trial Updated:
08/01/2025
Locations: Children's Hospital Colorado, Aurora, Colorado +19 locations
Conditions: Short Stature Homeobox- Containing Gene SHOX Deficiency, Noonan Syndrome, Turner Syndrome
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A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
NCT06683742
Recruiting
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/01/2025
Locations: Associated Retina Consultans, Gilbert, Arizona +154 locations
Conditions: Wet Age Related Macular Degeneration, wAMD
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Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
NCT06959550
Recruiting
The goal of this clinical research study is to learn if ivonescimab can help to control previously treated, metastatic colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Conditions: Metastatic Colorectal Cancer
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PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department
NCT07086560
Recruiting
Supraventricular tachycardia (SVT) is a dysrhythmia characterized rapid heart rate, typically with rapid onset. SVT accounts for over 50,000 emergency department visits per year. Of patients with regular, narrow-complex SVT, the mainstay of therapy includes adenosine and diltiazem. Adenosine is recommend by American and European guidelines as first-line therapy, however adenosine carries unique side effects that are potentially distressing to patients, including: "feeling of impending death or d... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/01/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Supraventricular Tachycardia (SVT)
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An Observational Study of Individuals With Isolated Dystonia
NCT07111663
Recruiting
This is an observational study in individuals with isolated (or primary) dystonia that involves more than one body region. The purpose of the study is to collect detailed information to help your physician and other researchers understand how dystonia impacts your and other patients' lives and how the disease changes over time. The study may also help researchers better understand the clinical scales that are commonly used to evaluate dystonia symptoms and how they affect various areas of life s... Read More
Gender:
ALL
Ages:
Between 12 years and 65 years
Trial Updated:
08/01/2025
Locations: Vima Site #004, Scottsdale, Arizona +20 locations
Conditions: Isolated/Primary Dystonia That Affects More Than One Region of the Body
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Generalization and Specificity of Visual Learning During Sleep
NCT07015840
Recruiting
A growing body of evidence suggests that sleep facilitates and is beneficial to perceptual learning. However, the underlying mechanism of this facilitatory action is largely unknown. One must know what type of processing occurs during sleep to clarify the mechanism of sleep facilitating perceptual learning. For this purpose, investigators will obtain highly localized spatio-temporal information about brain activation during sleep using magnetic resonance imaging (MRI) and polysomnography (PSG) m... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
08/01/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Visual Learning, Healthy Volunteers
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Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib
NCT07075471
Recruiting
The goal of this observational study is to better understand real-world use of vimseltinib, treatment patterns, and health-related quality of life in participants treated with vimseltinib for TGCT. This study will collect data in an observational disease registry involving no intervention to the participants and will not influence standard medical care or impact treatment decisions for participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: Synexus Clinical Research, US INC, Wilmington, North Carolina
Conditions: Tenosynovial Giant Cell Tumor
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A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
NCT07112001
Recruiting
This study will adapt and assess the preliminary effectiveness of a community health worker-delivered mental health counselling intervention delivered remotely to reduce anxiety and depression among people with HIV in Florida.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/01/2025
Locations: University of Florida, Gainesville, Florida
Conditions: HIV, Depression, Anxiety
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Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
NCT07103200
Recruiting
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
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A Study of Tarlatamab for People With Prostate Cancer
NCT07111507
Recruiting
The researchers are doing this study to find out whether tarlatamab is an effective treatment for DLL3-positive prostate cancer that has spread to other parts of your body (metastasized) and has either come back after treatment (relapsed) or not responded to treatment (refractory).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Metastatic Prostate Cancer
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A Study of LY4088044 in Healthy Participants
NCT07090785
Recruiting
The purpose of this study is to evaluate how well LY4088044 is tolerated and what side effects may occur in healthy participants. The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to check how much LY4088044 gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 92 weeks for Parts A, B, and C, excluding screening.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/01/2025
Locations: Collaborative Neuroscience Network - CNS, Los Alamitos, California +1 locations
Conditions: Healthy
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A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose
NCT07102095
Recruiting
This is a research study to understand how liver impairment affects the way the body processes a new cancer medicine called sevabertinib (BAY 2927088). Sevabertinib is an experimental drug being developed to treat certain types of cancers that have specific genetic changes called HER2 mutations. This includes lung cancer, tumors that have spread to other parts of the body (metastatic), and tumors that cannot be removed with surgery (unresectable). Before this medicine can be given to cancer pat... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/01/2025
Locations: Clinical Pharmacology of Miami, LLC - Oncology Department, Miami, Florida +1 locations
Conditions: Hepatic Insufficiency, Liver Diseases, Pharmacokinetics, Drug Metabolism
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