A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)
NCT06615050
Recruiting
The purpose of this study is to assess Tacrolimus/Methotrexate/Ruxolitinib versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Blood and Marrow Transplant Group of Georgia, Atlanta, Georgia +2 locations
Conditions: Graft-versus-host Disease (GVHD)
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A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease.
NCT06675175
Recruiting
The purpose of this study is to evaluate the safety, tolerability and the pharmacodynamics (PD) of AZD4144 following oral administration in participants with atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/09/2025
Locations: Research Site, Glendale, California +18 locations
Conditions: Chronic Kidney Disease, Atherosclerotic Cardiovascular Disease
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A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)
NCT06719141
Recruiting
This (DEEp OCEAN Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DEE. The study consists of 3 main phases: Screening, Titration period, Maintenance period, followed by a Taper period and Follow-Up. The total duration of the study will be approximately 24 months.
Gender:
ALL
Ages:
Between 2 years and 65 years
Trial Updated:
04/09/2025
Locations: Site Number - USA19, Little Rock, Arkansas +98 locations
Conditions: Developmental and Epileptic Encephalopathy
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A Digital Health Intervention to Improve Symptoms and Physical Activity During Breast Radiation
NCT06772181
Recruiting
This clinical trial evaluates a digital health intervention for improving symptoms and physical activity among patients with breast cancer undergoing radiation. Cancer-related fatigue is common and strongly associated with quality of life during and after treatment. Increasing emphasis on early symptom detection and management has prompted initiatives to collect patient-reported fatigue from all patients during treatment. Mind-body interventions including physical activity and yoga are recommend... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington +1 locations
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Carcinoma
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A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM
NCT06897202
Recruiting
This study is designed to test how well once-weekly MET097 (an ultra-long-acting GLP-1 receptor agonist) works to treat adults with obesity or overweight and type 2 diabetes mellitus (T2DM) compared to placebo. MET097 or placebo will be administered to individuals via subcutaneous injection once weekly for 28 weeks. If an individual is randomly assigned to MET097 they will receive one of four different dose regimens.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/09/2025
Locations: Research Site 097202-001001, Hollywood, Florida +4 locations
Conditions: Obesity in Diabetes, Type 2 Diabetes Mellitus (T2DM)
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A Phase 2a Study of LLX-424 in Patients With a History of Kidney Stones
NCT06932146
Recruiting
This is a Phase 2a study of glycolate oxidase inhibitor LLX-424 in patients with a history of kidney stones. Eligible subjects with a history of kidney stones will be randomized to receive study drug (LLX-424 or placebo) for 8 weeks.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/09/2025
Locations: Clinical Research Site #2, Saint Paul, Minnesota +2 locations
Conditions: Kidney Stones
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NutritiOUs fRuIts and veggieS to Improve Health: A Culinary Medicine Intervention
NCT06926972
Recruiting
This study includes a 12-week culinary medicine intervention integrated within the existing YMCA Suncoast Survivorship and Wellness Program Powered by Moffitt. Members of the John Geigle YMCA will be assigned to the NOURISH intervention, which includes biweekly provision of fruit and vegetable bundles, recipe cards, and nutritional education handouts plus 30-minute culinary medicine demonstrations with skill-building training (six total demonstrations focused on fruit and vegetable recipes).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Cancer, Nos
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MagDI U.S. Registry
NCT06928545
Recruiting
Assess the incidence and severity of internal hernia and bowel obstruction at one year in a U.S. population following use of the MagDI System to create side-to-side duodeno-ileal anastomoses.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/08/2025
Locations: Bariatric Specialists of the Carolinas, Cary, North Carolina
Conditions: Anastomosis, Surgical, Internal Hernia, Bowel Obstruction
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Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants
NCT06930417
Recruiting
The goal of this observational natural history study is to better characterize development, transition to adulthood, health and behavior of individuals diagnosed with Williams syndrome (WS) or carrying other variants of 7q11.23 chromosome and to build a DNA and tissue biobank with samples donated by affected individuals. The study has multiple arms focused on different aspects of WS. Participants with genetic diagnosis of WS or other variants of 7q11.23 and their family members are eligible to p... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/08/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Williams Beuren Syndrome, Williams Syndrome, Williams Beuren Region Duplication, Dup7
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The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
NCT06930495
Recruiting
This project is an observational study in patients with heart failure with preserved ejection fraction (HFpEF) who are candidates for treatment with weight loss medication to manage obesity or diabetes as part of their standard clinical care. This study will include multiple experimental visits before and after treatment (minimum 7 percent weight loss, between 9-12 months) to understand how increased adiposity and inflammation effects skeletal muscle and cardiovascular health and function and to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Heart Failure With Preserved Ejection Fraction (HFPEF)
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Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women
NCT00539162
Recruiting
The goal of this clinical research study is to evaluate a method involving 4 blood tests called CA-125, HE4, HE4 antigen autoantibody complexes, and osteopontin that may be helpful in the early detection of ovarian cancer in women who are at low risk.
Gender:
FEMALE
Ages:
Between 50 years and 74 years
Trial Updated:
04/08/2025
Locations: Sylvester Comprehensive Cancer Center, Univ of Miami Miller School of Medicine, Miami, Florida +10 locations
Conditions: Ovarian Cancer
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The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry
NCT01429727
Recruiting
The primary goal of this project is to describe the clinical and physiologic characteristics of Spontaneous Coronary Artery Dissections (SCAD) in order to increase awareness, understanding, treatment and prevention of a potentially fatal cardiovascular event. This study will be a retrospective and prospective review of medical course and current health of men and women with SCAD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Spontaneous Coronary Artery Dissection, SCAD
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