Lysosomal Acid Lipase (LAL) Deficiency Registry
NCT01633489
Recruiting
This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treatment of patients with LAL Deficiency. Participation in the Registry by both physicians and patients is voluntary.
Gender:
ALL
Ages:
All
Trial Updated:
04/08/2025
Locations: Not set, Phoenix, Arizona +85 locations
Conditions: Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2, Acid Lipase Deficiency, LIPA Deficiency, LAL-Deficiency
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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Immunogenicity of APG777 in Adults With Asthma
NCT06920901
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and immunogenicity of APG777 in adult participants with mild-to-moderate asthma. The duration of the study will be approximately 52 weeks (364 days) for each participant and will consist of a Screening Period, Treatment Period, and Follow-up Period.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/08/2025
Locations: Orso Health, La Jolla, California +9 locations
Conditions: Asthma
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Evaluation of the Safety, Tolerability and Pharmacokinetics of AH-001 Following Topical Single and Multiple Ascending Dose Administration
NCT06927960
Recruiting
The goal of this clinical trial is to assess the safety of the AH-001 drug substance at concentrations of 0.2%, 0.5%, 1%, and 2% in healthy volunteers and male subjects with androgenetic alopecia (AGA). Primary objective: * To evaluate the safety, tolerability, and pharmacokinetics profiles of a single ascending dose (SAD) of AH-001 in healthy volunteers. * To evaluate the safety, tolerability, and pharmacokinetics profiles of multiple ascending doses (MAD) of AH-001 in male subjects with andr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Inc., Los Angeles, California
Conditions: Androgenetic Alopecia
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A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies
NCT06916806
Recruiting
The purpose of this study is to measure the safety, tolerability, PK, and PD of AZD5492 administered subcutaneously in adult participants with SLE or IIM. Study details include: • The study duration will be a minimum of 180 days in addition to the screening period. Additional follow-up visits may be required up to 12 months from study start. * Depending on the study part they are assigned to, participants will be administered AZD5492 once (Part 1) or twice (Part 2). * Study visits will occur... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/07/2025
Locations: Research Site, Anniston, Alabama +21 locations
Conditions: Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
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This Study Explores Whether Adding Natural Elements Like Plants and Sunlight to Indoor Gyms Makes Exercise Feel Easier, More Enjoyable, and Improves Performance. By Comparing Workouts in Nature-inspired and Plain Gym Settings, it Aims to Find Better Ways to Design Fitness Spaces in Cities.
NCT06928311
Recruiting
The goal of this observational study is to examine whether exercising in a biophilic environment - a space designed to include natural elements like real plants, simulated sunlight, nature sounds, and outdoor views - can improve exercise performance and enjoyment compared to a standard indoor gym environment in male college students age 18-25 who have regularly exercised prior. The main question it aims to answer is: "Can biophilic design enhance the physical and mental benefits of indoor exerc... Read More
Gender:
MALE
Ages:
Between 18 years and 25 years
Trial Updated:
04/07/2025
Locations: Colorado State University Cardio Room (Moby Arena 134), Fort Collins, Colorado
Conditions: Biophilic Environmental Design, Traditional Exercise Design
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Assessing Patient Satisfaction and Confidence After Use of Educational Video to Augment Surgical Consent for Thyroid Surgery
NCT06918223
Recruiting
This study looks at how a short educational video can help people better understand thyroid surgery. Patients who have thyroid nodules and need surgery will be part of the study. Some patients will get the usual information from their doctor, while others will also watch a video that explains the surgery in a simple and clear way. The study will check if the video helps patients feel more confident about their decision, lowers anxiety, and helps them remember important information about their su... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Thyroid Cancer
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Data Collection Protocol for the Development of CHLOE-OQ, an AI Model for Assessing Oocytes Quality.
NCT06928337
Recruiting
This data collection protocol is aimed to allow the reliable and robust development (training, verification, and validations) of CHLOE technology-based applications as well as improve the machine learning stage of released devices/applications. Additionally, a simulated use assessments will be conducted to ensure the correct and easy use of the CHLOE applications.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: The World Egg and Sperm Bank, Scottsdale, Arizona
Conditions: Fertility Disorders
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U-POEM vs CO2-POEM
NCT06918730
Recruiting
Multicenter randomized trial comparing post-procedural pain intensity after Per-Oral endoscopic myotomy (POEM) between two types of standard of care insufflation methods (CO2 vs Underwater). POEM is routinely performed under carbon dioxide insufflation (CO2-POEM) as this gas is more rapidly absorbed than air, which has been shown to reduce gas-related complications. Water immersion for luminal distension of the GI tract as opposed to carbon dioxide insufflation has been shown to be associated... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: AdventHealth Orlando, Orlando, Florida
Conditions: Esophageal Motility Disorders
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Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
NCT06928467
Recruiting
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. The overarching goal of this project is to improve education and support for caregivers of persons living with dementia so that they can take better care of themselves and also their person living with dementia. Building Better Caregivers workshop i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: University of California, San Francisco, San Francisco, California +1 locations
Conditions: Family Caregivers, Dementia, Self-management, Depression, Internet-based Intervention
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Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+
NCT06919328
Recruiting
This study evaluates the subjective effects of injection administration of NR on healthy adult populations.
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
04/07/2025
Locations: Nutraceuticals Research Institute, Huntsville, Alabama
Conditions: Healthy Aging
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A Study of Ivonescimab in People With Endometrial and Cervical Cancers
NCT06925724
Recruiting
The researchers are doing this study to find out if ivonescimab is an effective treatment for people with endometrial cancer (EC) and/or cervical cancer (CC). The researchers will also look at whether the study drug is safe and causes few or mild side effects in participants.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Endometrial Cancer, Cervical Cancer
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Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011
NCT06925919
Recruiting
Phase 1 randomized, double-blind, placebo-controlled trial to evaluate safety, tolerability, pharmacokinetics (PK) and immunogenicity of IDB-011 following intramuscular (IM )administration of single ascending doses to healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Cypress, California
Conditions: Rift Valley Fever
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