Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
NCT06635785
Recruiting
BIPAVE-001 is a Phase 1-2 study for evaluating the safety, pharmacokinetics (PK), and efficacy of AI-081 in solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +16 locations
Conditions: Advanced Solid Tumor
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CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation
NCT06762964
Recruiting
The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 6 months affects pulmonary capillary wedge pressure (PCWP) at rest and during exercise in adults with failing Fontan circulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Fontan Circulation, Single Ventricle Heart Disease, HFpEF - Heart Failure with Preserved Ejection Fraction
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Clinical Investigation of MAIA Microperimeter Device: Mesopic Normative Database Collection
NCT06991127
Recruiting
The purpose of this pre-market, multicentric cross-sectional study is to create a mesopic Normative Database for a new version of the MAIA device. Moreover, the study aims to evaluate MAIA safety and adverse events. These purposes will be achieved by collecting data of healthy subjects, who will undergo microperimetric examinations with the MAIA device during one single visit.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: The Eye Care Institute, Fort Lauderdale, Florida +2 locations
Conditions: Healthy Eyes
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Bladder Cancer Longitudinal Biorepository for Development of Novel Therapeutics/Biomarkers
NCT03413982
Recruiting
The purpose of this study is to create a registry, which is a "bank" of information about patients who have had similar medical conditions and treatments. The registry will be used by researchers to learn more about long term outcome of patients with bladder cancer, how bladder cancer tissues are related to tumor development, recurrence and survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Bladder Cancer
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Durvalumab and Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer
NCT04607954
Recruiting
This phase II trial studies the effects of durvalumab and lurbinectedin in treating patients with extensive stage small cell lung cancer that has come back (relapsed) or has not responded to previous treatment with chemotherapy and immunotherapy (refractory). Monoclonal antibodies, such as durvalumab, may interfere with the ability of tumor cells to grow and spread. Lurbinectedin is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Platinum-Sensitive Lung Small Cell Carcinoma, Recurrent Extensive Stage Lung Small Cell Carcinoma, Refractory Extensive Stage Lung Small Cell Carcinoma, Platinum-Resistant Lung Small Cell Carcinoma
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The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction
NCT05109208
Recruiting
Researchers are trying to determine whether there is additional utility to using vibroelastography, a noninvasive ultrasound technique to evaluate for the presence of tissue fibrosis, in conjunction with standard penile duplex Doppler ultrasound to assess erectile function (recovery) after prostate cancer surgery.
Gender:
MALE
Ages:
40 years and above
Trial Updated:
05/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Prostate Adenocarcinoma
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Imatinib TDM in GIST
NCT05493215
Recruiting
Imatinib can lead to long recurrence free survival in patients diagnosed with gastrointestinal stromal tumors (GIST); however side effects can significantly hinder quality of life for our patients. This study will use therapeutic drug monitoring to improve quality of life and symptoms and assess how many patients maintain therapeutic levels. Free drug levels and pharmokinetics of imatinib will also be monitored.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Markey Cancer Center, Lexington, Kentucky
Conditions: Gastrointestinal Stromal Tumors
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Evaluation of Correlation Between Oculometric Measures and Clinical Assessment in Parkinson's Disease
NCT05862649
Recruiting
This is a multicenter longitudinal study in about 300 patients with Idiopathic Parkinson's disease, who will be evaluated in several clinical centers with a clinical assessment and an oculometric examination during a time period with specific intervals. This study aims to evaluate the correlation between oculometric measures and clinical assessment over time, as well as the potential to detect early change in clinical status using an oculometric assessment.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
05/19/2025
Locations: Rush University, Chicago, Illinois +4 locations
Conditions: Parkinson Disease
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SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II)
NCT06140303
Recruiting
The purpose of this study is to assess the safety and efficacy of SkinTE for treatment of Wagner grade 1 diabetic foot ulcers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Titan Clinical Research, Mesa, Arizona +22 locations
Conditions: Diabetic Foot
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A Study Collecting Health Information to Understand and Prevent Gastric Cancer
NCT06370143
Recruiting
The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia. Normal controls and individuals with gastric cancer for comparison of baseline characteristics will also be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Gastric Atrophy, Gastric Intestinal Metaplasia, Dysplasia, Gastric Adenocarcinoma, Gastric Cancer
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The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
NCT06535867
Recruiting
Mobile health (mHealth) will be used for early detection of oral cancer and pre-cancer lesions, and to improve awareness of oral cancer among the population and knowledge of oral cancer diagnosis among frontline health providers. This program is inclusive of long term surveillance to downstage oral cancer in India
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Memorial Sloan Kettering Cancer Center (All protocol activites), New York, New York
Conditions: Smoking, Smoking, Cigarette, Smoking, Tobacco, Betel Chewer's Mucosa, Tobacco Use, Tobacco Smoking, Alcohol Drinking, Smokeless Tobacco Hyperkeratosis
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A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
NCT06637462
Recruiting
The purpose of the study is to learn more about how the body responds to standard treatment (chemoradiation and chemotherapy). The study will use the results of testing down on participants' blook, tissue, and scans to learn more about how people with rectal cancer respond to chemoradiation and chemotherapy treatment and if it is useful for predicting whether a person's cancer get better, gets worse, or stats the same after treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Memorial Sloan Kettering Monmouth (Limited protocol activities), Middletown, New Jersey +5 locations
Conditions: Rectal Cancer, Adenocarcinoma of the Rectum
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