Virtual Reality-Integrated Propulsion Feedback for Stroke Rehab
NCT07087743
Recruiting
This study evaluates a novel Virtual Reality (VR)-integrated visual feedback system designed to enhance limb propulsion during robot-assisted gait rehabilitation in individuals post-stroke. In collaboration with CUREXO, a rehabilitation robotics company, the system is embedded within the Morning Walk® end-effector robot and provides real-time visual feedback to facilitate symmetrical use of the paretic and non-paretic limbs. The goal is to address gait asymmetry commonly observed in hemiparetic... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
07/31/2025
Locations: University of Texas Medical Branch, Galveston, Texas
Conditions: Stroke, Robot Assisted Gait Training, Virtual Reality
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Optimizing Gait Symmetry After Stroke Using Mechanical Constraints and Sensory Feedback
NCT07087769
Recruiting
This single-session study aims to evaluate a novel gait training protocol that integrates mechanical constraints and sensory feedback to enhance paretic leg propulsion in individuals post-stroke. The study will include 15 individuals who have experienced a stroke and 15 healthy adults, each aged 20 years or older. Participants will walk on both tied-belt and split-belt treadmills under various training conditions, including backward-directed resistance (applied at the pelvis, ankle, or both) and... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
07/31/2025
Locations: University of Texas Medical Branch, Galveston, Texas
Conditions: Stroke, Split-belt Treadmill, Resistance Exercise, Feedback, Gait Training
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Safety and Efficacy of Boric Acid Inserts for Treatment of Vulvovaginal Candidiasis
NCT07109869
Recruiting
This is a Phase 3 clinical study to evaluate the efficacy, safety, and tolerability of boric acid 600 mg vaginal inserts in patients with VVC.
Gender:
FEMALE
Ages:
12 years and above
Trial Updated:
07/31/2025
Locations: Alliance for Multispecialty Research - Mobile, Mobile, Alabama +19 locations
Conditions: Vulvovaginal Candidiases, Vulvovaginal Candidiasis, Genital, Vulvovaginal Candidiasis (VVC)
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Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States
NCT07110688
Recruiting
In this program, the investigators will develop novel multimodal neural-behavioral-physiological monitoring tools (software and hardware), and machine learning models for mental states within social processes and beyond. The tools consist of a multimodal skin-like wearable sensor for physiological and biochemical sensing; a conversational virtual human platform to evoke naturalistic social processes; audiovisual affect recognition software; synchronization tools; and machine learning methods to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California +1 locations
Conditions: No Condition, Study Mental State in Healthy Populations and Drug-resistant Epilepsy Patients With Existing iEEG
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A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
NCT00493688
Recruiting
To validate a new method for assessing perioperative risk in the cancer patient undergoing major cancer surgery. In this proposed study researchers will: 1. Measure preoperative energy reserve capacity (fitness) 2. Determine if postoperative morbidity is a function of perioperative cardiopulmonary gas exchange metabolism
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Abdominal Cancer, Pelvic Cancer
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Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
NCT00929006
Recruiting
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than sleep-associated LH frequency. (2) We will determine if in mid- to late pubertal girls with HA, P4 will acutely suppress waking LH frequency to a lesser degree than it does in girls without HA.
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
07/30/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Puberty, Hyperandrogenism
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Long-Term Follow-Up of Recipient of Gene Transfer Research
NCT01492036
Recruiting
The goal of this clinical research study is to collect information about the long-term safety of gene transfer therapy. This study is also designed to create a database of medical information about patients who have received gene transfer therapy, in order for researchers to track and review the long-term safety and any effects (good or bad) of gene transfer therapy.
Gender:
ALL
Ages:
All
Trial Updated:
07/30/2025
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Retroviridae Infections, Cancer
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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
NCT01760005
Recruiting
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive/clinical impairment or improves disease-related biomarkers.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/30/2025
Locations: University of Alabama in Birmingham, Birmingham, Alabama +37 locations
Conditions: Alzheimers Disease, Dementia, Alzheimers Disease, Familial
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A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
NCT02138734
Recruiting
This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +59 locations
Conditions: Non-muscle Invasive Bladder Cancer
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Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker
NCT02691923
Recruiting
This clinical research will evaluate the diagnostic potential of fluorescein as visualized through an operating microscope relative to 1) contrast enhancement on co-registered preoperative MR scans, 2) intraoperative ALA-induced PpIX fluorescence and 3) gold-standard histology obtained from biopsy sampling during the procedure. Subjects will include those people with operable brain tumor with first-time presumed pre-surgical diagnosis of high-grade glioma or low-grade glioma.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/30/2025
Locations: Sally B Mansur, Lebanon, New Hampshire
Conditions: Brain Cancer
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Hyperandrogenemia and Altered Day-night LH Pulse Patterns
NCT03068910
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
07/30/2025
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
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Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
NCT03218137
Recruiting
Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/30/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Premature Ventricular Contraction (PVC)
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