BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S
NCT06540079
Recruiting
The purpose of the BIO-CONDUCT study is to demonstrate the safety and effectiveness of the BIOTRONIK Solia CSP S pacing lead when implanted in the left bundle branch area (LBBA). Safety will be assessed by evaluating serious adverse device effects that occur through 3 months post-implant. Efficacy will be assessed by evaluating implant success rate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Banner - University Medical Center Phoenix, Phoenix, Arizona +8 locations
Conditions: Sinus Node Dysfunction, Bradycardia, Atrioventricular Block
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Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People With HIV-1
NCT06630286
Recruiting
The goal of this clinical study is to learn about the safety and efficacy of switching to once weekly tablet of islatravir/lenacapavir (ISL/LEN) regimen versus continuing standard treatment of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with human immunodeficiency virus (PWH) who are virologically suppressed (HIV-1 RNA levels \< 50 copies/mL) on B/F/TAF for ≥ 6 months prior to screening. The primary objective is to evaluate the efficacy of switching to oral weekly ISL/LE... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +105 locations
Conditions: HIV-1-infection
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Study of Fetal Health Outcomes: Working With a Missouri E-telehealth Platform (The SHOW-ME Study)
NCT06741735
Recruiting
The goal of this clinical trial is to evaluate the potential benefit to patients and providers from using the remote fetal-monitoring system NUVO along with its app to allow for pregnant patients requiring weekly non-stress testing to do so from their homes. The main questions the investigators are looking to answer are: What effect does the NUVO remote fetal monitoring system have on patient/provider satisfaction? What is the cost savings (both direct and indirect) from using a remote fetal m... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Missouri, Columbia, Missouri +2 locations
Conditions: Pregnancy
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Investigating the Effect of Topical Imiquimod on Sebaceous Hyperplasia
NCT06840470
Recruiting
This study is being completed to determine if 8 weeks of treatment with imiquimod can shrink sebaceous hyperplasia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Sebaceous Hyperplasia
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Dose Response of Exercise for Arthritis Management
NCT06880653
Recruiting
The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Arthritis, Rheumatoid Arthritis (RA), Gout, Fibromyalgia (FM), Osteoarthritis, Lupus Erythematosus, Systemic
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Evaluation of AI Cost Prediction Model to Enroll Patients in Complex Care Management Program
NCT06916247
Recruiting
Currently, UCLA Health (specifically the Office of Population Health and Accountable Care, or OPHAC) runs a complex care management program called Proactive Care (goal is to reduce care utilization by providing personalized care navigation/case management). Every month, an AI Population Risk tool runs to identify around 250 of the 480,000 or so UCLA primary care patients, and RNs contact these 250 patients to enroll in Proactive Care. Starting in December 2024, OPHAC launched a new method of enr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: UCLA Health, Los Angeles, California
Conditions: Chronic Disease
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Studies of Neuregulin/ERBB Signaling in Human Heart
NCT02820233
Recruiting
This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Maine Medical Center, Portland, Maine
Conditions: Heart Disease, Vascular Disease, Heart Failure
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Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis
NCT04166396
Recruiting
The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Cystic Fibrosis
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Cardiovascular and Neurovascular Regulation in GWI
NCT04586049
Recruiting
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
Gender:
ALL
Ages:
Between 45 years and 68 years
Trial Updated:
03/31/2025
Locations: University of Wisconsin-Madison, Madison, Wisconsin
Conditions: Brain Blood Flow, Neurovascular Control
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Randomized Trial of Sedative Choice for Intubation
NCT05277896
Recruiting
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains unknown. Ketamine and etomidate are the two most commonly used sedatives during intubation of critically ill adults. D... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: UAB Hospital, Birmingham, Alabama +5 locations
Conditions: Acute Respiratory Failure
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Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency Using Peripheral Blood and EFS ADA Vector
NCT05432310
Recruiting
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from mobilized peripheral blood (mPB) of ADA-deficient SCID infants and children following human ADA gene transfer by the EFS-ADA lentiviral vector. The level of gene transfer in blood cells and immune function will be measured as endpoints.
Gender:
ALL
Ages:
1 month and above
Trial Updated:
03/31/2025
Locations: University of California, Los Angeles (UCLA), Los Angeles, California
Conditions: Adenosine Deaminase Severe Combined Immune Deficiency
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A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT05552157
Recruiting
The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 will determine if treatment with the study drug prevents or slows the rate of amyloid beta (Aβ) pathological disease accumulation demonstrated by Aβ positron emission tomography (PET) imaging. Stage 2 will evaluate the effect of early Aβ plaque reduction/prevention on disease progression by assessing d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: University of Alabama in Birmingham, Birmingham, Alabama +34 locations
Conditions: Alzheimers Disease, Dementia, Alzheimers Disease, Familial
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