Study of BHV-1400 in IgA Nephropathy
NCT07054684
Recruiting
The purpose of this study is to determine if BHV-1400 is a safe and tolerable treatment in participants with IgA Nephropathy (IgAN).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: Site-003, Miami Lakes, Florida +4 locations
Conditions: IgA Nephropathy
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A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Adults, Including Those at Higher Risk of Severe COVID-19
NCT07069309
Recruiting
The purpose of this study is to learn about the safety, tolerability, and immunogenicity of an updated vaccine against COVID-19. This study is seeking participants 18 through 64 years of age who are considered to be at higher risk for severe COVID-19 disease per study protocol and those 65 years of age and older. All participants in this study will receive 1 shot to their arm of a BNT162b2 (Omi LP.8.1) 30 µg RNA-based vaccine which targets a circulating variant of SARS-CoV-2 and is selected for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Diablo Clinical Research, Inc., Walnut Creek, California +5 locations
Conditions: COVID-19, SARS-COV-2 Infection
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A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
NCT07085091
Recruiting
A Phase 1, First in Human, Open-Label Multicenter Study to Evaluate ALX2004, an Antibody Drug Conjugate Targeting EGFR in Participants with Advanced or Metastatic Select Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: START Midwest, Grand Rapids, Michigan +3 locations
Conditions: NSCLC (Advanced Non-small Cell Lung Cancer), HNSCC, CRC (Colorectal Cancer), ESCC, Colo-rectal Cancer, Head and Neck Cancer, Esophageal Squamous Cell Carcinoma (ESCC)
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Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
NCT07097051
Recruiting
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults. Those with lower alpha activity, especially in the front part of the brain, usually have problems with executive functions like planning and multitasking. Our research has shown that older adults with lower alpha power in these areas also struggle more with balance when they have to do two things at once (like standing and performi... Read More
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
07/30/2025
Locations: High Point University, High Point, North Carolina
Conditions: Mild Cognitive Impairment (MCI)
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Dose-Dependent Effects of Low-Intensity Focused Ultrasound
NCT07099950
Recruiting
Low-intensity focused ultrasound (LIFU) has emerged as a tool to modulate the activity of deep brain structures noninvasively and reversibly, with anatomical precision. Following the results of a pilot study in which the investigators observed target engagement when LIFU was applied to the anterior limb of the internal capsule, the investigators now propose to determine the dose-response relationships of LIFU when applied to deep white matter tracts of the human brain. The investigators hope a s... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Healthy Controls
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Hypnosis-Based Machine Learning Biomarker Study
NCT07102810
Recruiting
This study seeks to contribute to the growing body of literature on hypnosis by providing robust, data-driven insights into the physiological mechanisms underlying trance states. The integration of electroencephalogram (EEG) and other wearable-derived physiological data will offer a comprehensive assessment of the changes that occur during a standardized hypnosis protocol: the Harvard Group Scale of Hypnotic Susceptibility (HGSHS:A). The results of this study are intended to facilitate derivatio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: Mount Sinai Hospital, New York, New York
Conditions: Disorder; Trance, Anxiety
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Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects
NCT07107139
Recruiting
This study seeks to measure the effects of smokeless tobacco product risk messages on sensory experiences and future intentions to use.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/30/2025
Locations: Roswell Park, Buffalo, New York
Conditions: Smokeless Tobacco
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Psychosocial and Behavioral Intervention for Stem Cell Transplant Patients and Their Family Caregivers
NCT07107165
Recruiting
Adherence to the medical regimen after stem cell transplant is challenging for both patients and their family caregivers. The investigators propose a randomized clinical trial testing two brief psychosocial interventions to determine if either improves patient and family caregiver psychosocial and health-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Stem Cell Transplant, Hematopoetic Stem Cell Transplant, Hematopoetic Stem Cell Transplantation
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Diet and Microbiome Interactions: Application in Posttraumatic Stress Disorder in Adults Consuming Vegetable Drinks
NCT07107269
Recruiting
The gut microbiome has been shown to impact various facets of human health, including mental health. Studies have shown that populations with more agrarian lifestyles tend to have fewer chronic diseases and mental health issues than industrialized populations. A possible factor in these differences is the loss of co-evolved gut microbial taxa that has occurred with Westernization. This hypothesis, termed "Old Friends Hypothesis" suggests that the loss of certain gut microbes leads to immune dysr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: Food and Nutrition Clinical Research Lab - Colorado State University, Fort Collins, Colorado
Conditions: PTSD - Post Traumatic Stress Disorder
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Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
NCT05492578
Recruiting
This is an open-label, Phase 2/Phase 3, long-term extension study for treatment of participants of previous amlitelimab clinical trials in moderate to severe atopic dermatitis. The purpose of this study is to characterize the safety and efficacy of amlitelimab in treated participants with moderate to severe atopic dermatitis (AD) who have previously been enrolled in an amlitelimab clinical trial. All participants will have visits during the treatment period every 4 weeks. Responder participants... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/29/2025
Locations: Alabama Allergy & Asthma Center - Birmingham - Brookwood Boulevard- Site Number : 8401101, Birmingham, Alabama +163 locations
Conditions: Dermatitis Atopic
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A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
NCT05519475
Recruiting
This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have metabolic dysfunction-associated steatohepatitis (MASH). MASH is a form of metabolic dysfunction-associated steatotic liver disease (MASLD). MASH occurs when fat builds up in liver cells, damaging them, and making the liver inflamed and stiff from fibrosis (scar tissue). MASH can progress to cirrhosis (long term scarring) and liver failure (when the liver ca... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/29/2025
Locations: Arizona Liver Health, Chandler, Arizona +69 locations
Conditions: Metabolic Dysfunction-associated Steatohepatitis (MASH)
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Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults
NCT05523505
Recruiting
The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline readin... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Reading Disability
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