Novel Treatment for Rotator Cuff Tears
NCT05590494
Recruiting
The focus of this study is to examine changes in pain scores, strength, and range of motion over time following an ultrasonic tenotomy on a partial tear (\<50%) of the supraspinatus tendon of the rotator cuff.
Gender:
ALL
Ages:
Between 25 years and 75 years
Trial Updated:
07/29/2025
Locations: Mayo Clinic Health System - Onalaska, Onalaska, Wisconsin
Conditions: Supraspinatus Tear
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S.T.A.N.D. Alacrity Center Signature Project
NCT05591937
Recruiting
The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC). The target enrollment is 200 participants per year, for five years (N=1000). Participants are between the ages of 18 and 40 years and will be randomized into either symptom severity decision-making (SSD) or data-driven decision-making (DDD). Participan... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2025
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
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Impact of Improving Footwear Options
NCT05601869
Recruiting
Veterans with leg amputations have limited footwear options because their artificial feet do not change shapes for different shoes. Studies have shown that women with amputations receive more frequent prosthetics care than men, but are less satisfied with the fit, comfort, and appearance of their prostheses. The investigators' previous research indicates that women Veterans would like to be able to wear a broader variety of footwear, and those who perceive more footwear limitations tend to have... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/29/2025
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Amputation
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HEPA, PM2.5, and Cardiometabolic Health
NCT05718245
Recruiting
The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
07/29/2025
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Cardiometabolic Health
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PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism
NCT05756244
Recruiting
The PREP and GO study is an international multicentre prospective cohort evaluating anticoagulation management strategies around labor and delivery and the postpartum period.
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
07/29/2025
Locations: Duke University Hospital, Durham, North Carolina +9 locations
Conditions: Pregnancy Related, Venous Thromboembolism
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Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
NCT05776069
Recruiting
The VIVID study is structured in a master protocol format comprised of multiple parts that evaluate intravenous (IV) and subcutaneous (SC) VGA039 in healthy volunteers and subjects with von Willebrand Disease (VWD) and other bleeding disorders.
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
07/29/2025
Locations: Orthopedic Institute for Children (UCLA), Los Angeles, California +24 locations
Conditions: Von Willebrand Diseases
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Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Renal Colic Patients
NCT05776953
Recruiting
This is a prospective interventional study examining the effect of ketorolac at doses of 15mg versus 30 mg for duration of analgesia in emergency department patients with suspected renal colic.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/29/2025
Locations: Hackensack Univarsity medical Center, Hackensack, New Jersey
Conditions: Renal Colic, Flank Pain, Emergencies, Analgesia
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Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)
NCT05792189
Recruiting
Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence. Fixation of these fractures can be challenging due to altered anatomy for the TKA and the presence of the metallic femoral component and have a relatively high complication rate. As a result, some surgeons elect to treat these fractures with a distal femur replacement total knee arthroplasty (DFR). The purpose of... Read More
Gender:
ALL
Ages:
Between 55 years and 100 years
Trial Updated:
07/29/2025
Locations: UF & Shands Orthopaedics and Sports Medicine Institute, Gainesville, Florida
Conditions: Distal Femur Fracture
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Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC
NCT05798663
Recruiting
This is a phase II trial of neoadjuvant and adjuvant atezolizumab with or without tiragolumab in conjunction with chemoradiotherapy for unresectable stage III NSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: University of California San Diego Moores Cancer Center, La Jolla, California +14 locations
Conditions: NSCLC
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Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation
NCT05806515
Recruiting
This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells. Giving carboplatin before surgery may shrink tumors in patients with h... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +132 locations
Conditions: Prostate Adenocarcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8
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Natural History Study of Participants With Sanfilippo Syndrome Type IIIC
NCT05825131
Recruiting
This study is planned to document, through retrospective and prospective data collection, syndrome progression in children and young adults with MPS IIIC.
Gender:
ALL
Ages:
12 months and above
Trial Updated:
07/29/2025
Locations: The University of Texas Southwestern Medical Center, Dallas, Texas +1 locations
Conditions: Sanfilippo Syndrome Type C
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Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium (MPN-RC 120)
NCT05835466
Recruiting
This is an open label, phase II study to assess the efficacy, safety, and tolerability of Reparixin in patients with DIPSS intermediate-2, or high-risk primary myelofibrosis (PMF), post essential thrombocythemia/polycythemia vera related MF (Post ET/PV MF) after prior treatment, and those who are ineligible or refuse treatment, with a Janus kinase inhibitor (JAKi). 26 patients will be enrolled. Eligible patients will receive oral reparixin three times daily on a 4-week cycle for a core study per... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Moffitt Cancer Center, Tampa, Florida +8 locations
Conditions: Myelofibrosis (PMF), Post Essential Thrombocythemia Myelofibrosis (ET-MF), Post Polycythemia Vera Related Myelofibrosis (PV-MF)
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