Trifecta-Lung cfDNA-MMDx Study
NCT05837663
Recruiting
Demonstrate the relationship between dd-cfDNA levels and HLA antibodies in blood transplant recipient and Demonstrate the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from lung transplants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT, Phoenix, Arizona +11 locations
Conditions: Lung Transplantation
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Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
NCT05867381
Recruiting
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
07/29/2025
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Atherosclerosis
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First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors
NCT05875168
Recruiting
This study will evaluate the safety, tolerability, and efficacy of DS-3939a in participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Florida Cancer Specialists, Sarasota, Florida +23 locations
Conditions: Advanced Solid Tumor, Metastatic Solid Tumor
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Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
NCT05908565
Recruiting
The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided digitally with the assistance of trained community members without advanced degrees in mental health is an effective and scalable way to address these needs. Despite being effective for improving symptoms and functioning in those who engage in it, uptake a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2025
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
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Human Learning of New Structured Information Across Time and Sleep
NCT05910762
Recruiting
Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found evidence that it is also crucial for finding structure across experiences. The mechanisms of this essential form of learning have not been established. The investigators have developed a neural network mode... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
07/29/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Learning, Humans, Consolidation, Sleep
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NLP-Based Feedback to Improve Risk Comms and Informed Shared Decision Making
NCT05923684
Recruiting
In this pilot study, the investigators will show feasibility of the NLP-based feedback system in 20 consultations of men with newly diagnosed prostate cancer. The investigators will recruit from the practices of up to 10 physicians who typically see these patients. The investigators will report the top five sentences from each consultation across key content areas (cancer prognosis, life expectancy, erectile dysfunction, urinary incontinence, and irritative urinary symptoms) to both patients and... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Prostate Cancer
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reSET for the Treatment of Stimulant Use in HIV Clinics: Care Optimization Supporting Treatment Adherence (COSTA)
NCT05958017
Recruiting
The purpose of this study is to find out if reSET, an FDA authorized mobile therapeutic, is effective in treating stimulant use disorder and helping keep HIV viral load suppression stable among men who have sex with men who are living with HIV and have a stimulant use disorder.
Gender:
MALE
Ages:
Between 18 years and 90 years
Trial Updated:
07/29/2025
Locations: University of Miami, Miami, Florida
Conditions: Stimulant Use Disorder, People Living With HIV, reSET
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PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
NCT05994014
Recruiting
Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Coronary Artery Disease, Atherosclerosis, Coronary Atherosclerosis of Native Coronary Artery
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Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
NCT06004674
Recruiting
The goal of this randomized clinical trial is to evaluate if we can use placental pathology in a prior pregnancy which had an adverse outcome, such as early delivery, stillbirth, a baby born smaller than expected, or severe forms of high blood pressure during pregnancy, to guide treatment in the subsequent pregnancy and reduce risk of recurrent adverse pregnancy events. The main questions it aims to answer are: * Whether enoxaparin prevents recurrent adverse pregnancy outcomes among patients w... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/29/2025
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Adverse Pregnancy Outcome
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Biomechanical Validation of the CATT
NCT06013878
Recruiting
As of 2020, 53 million Americans provide unpaid care to an individual with a disability. One commonly performed activity of daily living (ADL) provided by informal caregivers is assisted transfers, which requires moving an individual from one surface to another. Approximately 94% of informal caregivers who assist with ADLs to persons with adult-onset chronic physical disabilities affecting mobility reported musculoskeletal discomfort, with pain and discomfort made worse by performing caregiving... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Informal Caregivers, Low Back Pain, Biomechanics
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A Study to Investigate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986326 in Adult Participants With Different Forms of Lupus
NCT06013995
Recruiting
The purpose of this study is to evaluate safety, drug levels and drug effects on cells and organs of the body, after receiving multiple increasing doses of BMS-986326 via intravenous (IV) infusion or subcutaneous (SC) injection, in participants with different forms of lupus.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/29/2025
Locations: Local Institution - 0048, San Diego, California +26 locations
Conditions: Lupus
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A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
NCT06016842
Recruiting
The participants of this study will have confirmed Primary Biliary Cholangitis (PBC) and cirrhosis (scarring of the liver). PBC is a slowly progressive disease, characterised by damage to the bile ducts in the liver, leading to a build-up of bile acids which causes further damage. The liver damage in PBC may lead to cirrhosis. PBC may also be associated with multiple symptoms. Many patients with PBC may require liver transplant or may die if the disease progresses and a liver transplant is not... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Arizona Liver Health, Tucson, Arizona +147 locations
Conditions: Primary Biliary Cholangitis (PBC)
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