Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)
Recruiting
This is an open-label, multicenter, clinical study conducted in multiple parts to establish the safety, tolerability, Pharmacokinetic/Pharmacodynamic (PK/PD) profile, maximum tolerated dose (MTD) combinations (if observed) and recommended dose for expansion (RDE) combination for tuvusertib in combination with lartesertib (in Part A1), food effect on the PK of lartesertib as monotherapy followed by treatment with tuvusertib in combination with lartesertib in participants with specific tumor types... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Providence Medical Foundation, Santa Rosa, California +19 locations
Conditions: Metastatic or Locally Advanced Unresectable Solid Tumors
DLL3-Directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer
Recruiting
This is a phase 1, first-in-human, open-label, multicenter, dose escalation and expansion study of DLL3-targeted chimeric antigen receptor T-cells in subjects with extensive stage small cell lung cancer or large cell neuroendocrine lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Moffitt Cancer Center, Tampa, Florida +3 locations
Conditions: Small Cell Lung Cancer Extensive Stage, Large Cell Neuroendocrine Carcinoma of the Lung
Effects of Acupuncture on Perceived Stress and Health in Military Service Members
Recruiting
The goal of this is to investigate the effect of a Manual Standardized Stress Acupuncture (MSSA) protocol as an adjunct treatment to a short-term mindfulness therapy for perceived stress and general health in service members (i.e., active duty military personnel and veterans). The specific aims of this study are Aim 1) To evaluate the effectiveness of a brief MSSA as an adjunct treatment with a short-term Mindfulness-Based Stress Reduction (MBSR) compared with MBSR alone for perceived stress an... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/19/2025
Locations: Naval Medical Center, San Diego, San Diego, California
Conditions: Perceived Stress
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
Recruiting
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic ta... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: All sites listed under NCT06305780, Durham, North Carolina
Conditions: Long COVID, Long Coronavirus Disease 2019 (Covid19), Long Covid-19
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
Recruiting
This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies. The primary objective for the 48-Week Extension Phase is to evaluate the sa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/19/2025
Locations: IMC Gulf Coast Gastroenterology, PC, Fairhope, Alabama +148 locations
Conditions: Moderately to Severely Active Crohn Disease
Inhaled Ciclesonide Study in Preterm Infants
Recruiting
Our overall objective is to conduct a safety study with inhaled ciclesonide to evaluate known glucocorticoids (sGC)-related acute and intermediate toxic effects while measuring for the first time in neonates its systemic absorption and potential bioactivity (i.e. activation of primary target, the GR, in blood cells).
Gender:
ALL
Ages:
Between 8 days and 28 days
Trial Updated:
05/19/2025
Locations: Children's Mercy Kansas City, Kansas City, Missouri
Conditions: Bronchopulmonary Dysplasia
A Study of Barzolvolimab in Patients With Atopic Dermatitis
Recruiting
The purpose of this study is to assess the efficacy and safety of barzolvolimab in adults with Atopic Dermatitis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Cahaba Dermatology & Skin Health Center, Birmingham, Alabama +23 locations
Conditions: Atopic Dermatitis
Feasibility of Online-supported Delivery Bringing Optimal Nutrition to Diverse Low-income Households With Children
Recruiting
The goal of this study is to find ways to help families with children who have limited incomes get better access to healthy and culturally appropriate foods. The study will test a program called "medically tailored grocery box delivery," which sends boxes of healthy groceries to families based on their specific health needs. The study aims to answer: 1. Can this grocery delivery program improve families' access to healthy foods and support better eating habits? 2. Will families use the groceri... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/19/2025
Locations: Bronx Health REACH, New York City, New York
Conditions: Food Insecurity
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
Recruiting
This study is being conducted to help the investigators better understand how the new FDA approved medication Edaravone (also known as Radicava) works in subsets of patients with ALS. The investigators are also trying to understand if there are specific ALS patients, with different presentations of ALS, who might benefit most from this medication. Also, the investigators are following specific biomarkers to determine the optimal treatment duration in patients with different forms of ALS There i... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/19/2025
Locations: Loma Linda University, Loma Linda, California
Conditions: Amyotrophic Lateral Sclerosis
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Recruiting
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive decline.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
05/19/2025
Locations: Neurobehavioral Systems, Inc., Berkeley, California
Conditions: Alzheimer Disease, Aging, Cognitive Decline
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
Recruiting
This study will be conducted to evaluate the efficacy, safety, tolerability, and pharmacokinetics of masupirdine compared to placebo for the treatment of agitation in participants with dementia of the Alzheimer's type.
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
05/19/2025
Locations: Advanced Research Center, Inc., Anaheim, California +51 locations
Conditions: Agitation, Alzheimer's Type Dementia
Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases
Recruiting
To learn if giving nivolumab in combination with relatlimab can help to control melanoma that has spread to the brain (melanoma with brain metastases). The safety and side effects of the study drug combination will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Melanoma (Skin)