A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
NCT06826612
Recruiting
The main goal of this study is to evaluate the safety, tolerability, and preliminary efficacy of SPK-10001 in participants with Huntington's Disease.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
05/19/2025
Locations: University of Cincinnati/Cincinnati Children's Hospital, Cincinnati, Ohio +1 locations
Conditions: Huntington Disease
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Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
NCT03587701
Recruiting
A Phase II randomized, placebo controlled study design of anakinra (Kineret) in corticosteroid-resistant or intolerant Meniere's disease (CR-MD)and corticosteroid-resistant or intolerant autoimmune inner ear disease (CR-AIED) patients. Patients will be randomized by a 2:1 allocation to anakinra or placebo for 42 continuous days. After day 42, a second placebo-controlled period will begin for an additional 42 days. This will be followed by a 264 day observation period, during which, hearing decli... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/19/2025
Locations: Northwell Health, Hearing& Speech Center, New Hyde Park, New York
Conditions: Autoimmune Inner Ear Disease, Meniere's Disease
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Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
NCT04617522
Recruiting
The goals of this clinical study are to learn more about the safety and dosing of the study drug, sacituzumab govitecan-hziy, in participants with solid tumors and moderate liver problems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Pacific Shores Medical Group, Long Beach, California +9 locations
Conditions: Advanced or Metastatic Solid Tumor, Liver Failure
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CD4^LVFOXP3 in Participants With IPEX
NCT05241444
Recruiting
This first-in-human, Phase 1 clinical trial will test the feasibility of the manufacturing and the safety of the administration of CD4\^LVFOXP3 in up to 30 evaluable human participants with IPEX and evaluate the impact of the CD4\^LVFOXP3 infusion on the disease.
Gender:
MALE
Ages:
Between 4 months and 35 years
Trial Updated:
05/19/2025
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: IPEX
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Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
NCT05526560
Recruiting
Collect real-world data on acute and long-term safety and performance of the MITRIS RESILIA Mitral Valve, Model 11400M, in subjects requiring replacement of their native or prosthetic mitral valve with or without concomitant procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +36 locations
Conditions: Mitral Stenosis, Mitral Valve Insufficiency
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National Fully Remote Use of IpsiHand Device in Hemiparetic Stroke
NCT05965713
Recruiting
The goal of this study is to define the efficacy of fully remote home-based BCI therapy in chronic hemiparetic subcortical stroke patients. A randomized controlled study using the integrated remote BCI system will be tested against standard exercise therapy to determine the efficacy of motor improvement in chronic stroke patients with an upper extremity hemiparesis. Specifically, the integrated BCI system will include 1) the remote screening and motor assessment system for the upper extremity an... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/19/2025
Locations: Neurolutions, Saint Louis, Missouri
Conditions: Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Brain Computer Interface
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A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
NCT06226883
Recruiting
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 2 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's disease (CD).
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/19/2025
Locations: Clinical Study Site, Lancaster, California +138 locations
Conditions: Inflammatory Bowel Diseases, Crohn's Disease
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Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries
NCT06379425
Recruiting
This is a double-arm randomized control trial evaluating the impact of preoperative opioid-free analgesia on time to trial of void in ambulatory urogynecologic surgeries. The investigators hypothesize that receipt of acetaminophen, celecoxib and gabapentin preoperatively versus acetaminophen alone will reduce the time to trial of void in patients undergoing same-day minor urogynecologic procedures.
Gender:
FEMALE
Ages:
All
Trial Updated:
05/19/2025
Locations: Northwell Health South Shore Surgery Center, Bay Shore, New York
Conditions: Pain, Postoperative, Postoperative Pain, Acute
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Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
NCT06541262
Recruiting
The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors. An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone or in combination with any drug, for the condition or illness it is being used to treat. The goals of this part of the study are: * Establish a recommended dose of... Read More
Gender:
ALL
Ages:
30 years and below
Trial Updated:
05/19/2025
Locations: Arnold Palmer Hospital for Children, Orlando, Florida +4 locations
Conditions: Neuroblastoma Recurrent, Ewing's Sarcoma Recurrent, Osteosarcoma Recurrent, Rhabdomyosarcoma Recurrent, Liposarcoma Recurrent
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The Effects of Endotracheal Suctioning on Pain and Serum Markers
NCT06692400
Recruiting
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress. The main questions this study aims to answer are: Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Loma Linda University Medical Center Troesh Medical Campus, Loma Linda, California
Conditions: Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation, Pain Measurement, Pain, Procedural, Oxidative Stress, Hypoxia, Biomarkers / Blood, Adult, Uric Acid, Sepsis, COVID, Influenza, Pneumonia
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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
NCT06830798
Recruiting
The primary objective of this study is to demonstrate the efficacy of ravulizumab vs placebo in reducing the severity of DGF as measured by time to freedom from dialysis in adult participants who are at high risk of DGF after undergoing transplant of deceased donor kidney.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Research Site, Phoenix, Arizona +118 locations
Conditions: Delayed Graft Function, DGF, Kidney Transplant
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A Study of EBC-129 in Advanced Solid Tumours
NCT05701527
Recruiting
This study will assess the safety and tolerability of EBC-129 as a single agent and in combination with pembrolizumab in patients with advanced solid tumours
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/18/2025
Locations: University of Colorado Hospital (UCH) - University of Colorado Cancer Center (UCCC) - Neuroendocrine Tumor Center, Aurora, Colorado +4 locations
Conditions: Advanced Solid Tumours
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