Pembrolizumab in Treating Participants With Leukoplakia
Recruiting
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: UC San Diego Moores Cancer Center, La Jolla, California +2 locations
Conditions: Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
Cereset Research Exploratory Study
Recruiting
The purpose of this study is to evaluate the use of Cereset Research to improve autonomic function in participants with symptoms of stress, anxiety, or insomnia.
Gender:
ALL
Ages:
11 years and above
Trial Updated:
07/28/2025
Locations: Wake Forest University Health Scienc\ess, Winston-Salem, North Carolina
Conditions: Neurological Diseases or Conditions, Cardiovascular Conditions After Birth, Psychophysiologic Disorders
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Recruiting
This trial studies how an imaging agent, hyperpolarized carbon C 13 pyruvate, works in diagnosing glioma in patients with brain tumors. Giving hyperpolarized carbon C 13 pyruvate before an advanced imaging technique called a magnetic resonance spectroscopic imaging (MRSI) scan may help researchers better diagnose glioma in patients with brain tumors.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
07/28/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Primary Brain Neoplasm
Patient Decision Aid in Supporting Decision-Making About When to Start or Stop New Drugs, Join Clinical Trials, or Continue Active Surveillance in Patients With Medullary Thyroid Cancer and Their Caregivers
Recruiting
This trial develops and studies how well a patient decision aid works in supporting decision-making about when to start or stop new drugs, join clinical trials, or continue active cancer monitoring for patients with medullary thyroid cancer and their caregivers. Developing a patient decision aid may help patients with medullary thyroid cancer make well-informed decisions about their cancer care and be able to discuss their preferences with their doctors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Thyroid Gland Medullary Carcinoma
Comparison of Standard vs. Accelerated Corneal Crosslinking
Recruiting
The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
07/28/2025
Locations: Price Vision Group, Indianapolis, Indiana
Conditions: Keratoconus, Ectasia Corneal
Pulmonary Hypertension Association Registry
Recruiting
The PHA Registry (PHAR) is a national study about people who have pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). PHAR collects information from people with PAH and CTEPH who are cared for in participating PHA-accredited Pulmonary Hypertension Care Centers throughout the U.S. PHAR will determine how people with PAH and CTEPH are evaluated, tested, and treated, and will observe how well these participants do. The goal is to see if people with PH a... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
07/28/2025
Locations: Arizona Pulmonary Specialists, Ltd., Phoenix, Arizona +51 locations
Conditions: Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Hypertension
The Effect of Yoga Practice on Chronic Back Pain
Recruiting
Chronic low back pain is notoriously difficult to treat and is a primary contributor to lost work days and excessive health expenditures, and whose treatment has, in part, contributed to the opioid crisis. Surgery is only an option in a minority of these patients, usually confined to those with structural instability. Yoga is an ancient modality whose benefits are currently being studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: NYULangone, New York, New York
Conditions: Chronic Back Pain
STRIVE Post-Market Registry Study
Recruiting
This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-market setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Dignity Health St. Joseph's Hospital and Medical Center, Phoenix, Arizona +11 locations
Conditions: Emphysema
PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer
Recruiting
This phase I trial studies the side effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in treating patients with ovarian, uterine, appendiceal, stomach (gastric), or colorectal cancer that has spread to the lining of the abdominal cavity (peritoneal carcinomatosis). Chemotherapy drugs, such as cisplatin, doxorubicin, oxaliplatin, leucovorin, fluorouracil, mitomycin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: City of Hope Medical Center, Duarte, California +2 locations
Conditions: Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8, Clinical Stage IVB Gastric Cancer AJCC v8, Malignant Uterine Neoplasm, Metastatic Colorectal Carcinoma, Metastatic Gastric Carcinoma, Metastatic Malignant Neoplasm in the Peritoneum, Metastatic Ovarian Carcinoma, Pathologic Stage IV Gastric Cancer AJCC v8, Peritoneal Carcinomatosis, Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8, Stage IV Colorectal Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Uterine Corpus Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVA Ovarian Cancer AJCC v8, Stage IVA Uterine Corpus Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVB Ovarian Cancer AJCC v8, Stage IVB Uterine Corpus Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8, Metastatic Appendix Carcinoma, Metastatic Malignant Solid Neoplasm, Stage IV Appendix Carcinoma AJCC v8, Stage IVA Appendix Carcinoma AJCC v8, Stage IVB Appendix Carcinoma AJCC v8, Stage IVC Appendix Carcinoma AJCC v8
Cerebrospinal Fluid Biomarkers in Bariatric Surgery
Recruiting
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid (CSF) neuropeptide, hormone and protein levels will be measured as a surrogate for changes in brain activity in participants before and after bariatric surgery as compared with participants before and after diet-induced weight loss. The investigators are studying neuropeptides and hormones that are know to be involved with the regulation... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/28/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Obesity
Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer
Recruiting
This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and can be performed for at least 10 minutes. The researchers will study the effects of different exercise programs on how well the study participants' bodi... Read More
Gender:
FEMALE
Ages:
Between 21 years and 80 years
Trial Updated:
07/28/2025
Locations: Hartford Healthcare Cancer Institute @ Hartford Hospital (Data Collection Only), Hartford, Connecticut +1 locations
Conditions: Early Stage Breast Cancer
PET Detection of CCR2 in Human Atherosclerosis
Recruiting
: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/28/2025
Locations: Washington University CCIR, Saint Louis, Missouri
Conditions: Carotid Atherosclerosis