Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss
Recruiting
The goal of this study is to develop and pilot test a therapeutic strategy combining cognitive behavioral therapy (CBT) with mindfulness practices tailored for individuals adjusting to vision loss. The study will begin with focus groups to inform the design of the intervention. Participants will complete brief surveys on their background and experiences with vision loss prior to attending a focus group, and some may be invited to a second session to provide additional feedback before preliminary... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: The Chicago Lighthouse, Chicago, Illinois
Conditions: Depression, Anxiety, Visual Impairment, Adjustment, Adjustment Disorder With Anxious Mood, Adjustment Disorder With Depressed Mood, Blindness, Acquired, Blindness and Low Vision, Vision Loss
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
Recruiting
The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and... Read More
Gender:
ALL
Ages:
Between 50 years and 75 years
Trial Updated:
07/25/2025
Locations: Department of Nutritional Sciences, Storrs, Connecticut
Conditions: Healthy Aging, Inflammation
Smartphone Services for Stimulant Use Disorder
Recruiting
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S. but there is no FDA-approved medication to treat it. There is a behavioral approach that has been found to be the most effective treatment for Stimulant Use Disorder, but this study is testing whether this can be delivered by a smartphone service, remotely, such as at home.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: This is an At-Home Study - no travel or on-site visits are needed at all; Main Office: 6 Liberty Sq, #2102, Boston, Massachusetts
Conditions: Stimulant Use Disorder
A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma
Recruiting
The purpose of this study is to find out whether Tec-RVd (teclistamab, lenalidomide, bortezomib, and dexamethasone) after 3 treatment Cycles of Dara-RVd (daratumumab, lenalidomide, bortezomib, and dexamethasone) is a safe treatment for people with newly diagnosed multiple myeloma (MM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Multiple Myeloma
Clinical Trial Readiness for the Dystroglycanopathies
Recruiting
The purpose of the study is to describe the early signs and symptoms of the dystroglycanopathies, and to gather information that will be required for future clinical trials.
Gender:
ALL
Ages:
All
Trial Updated:
07/24/2025
Locations: University of Iowa, 200 Hawkins Drive, Iowa City, Iowa
Conditions: Muscular Dystrophy
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea
Recruiting
Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating moderate-substantial interrater and test-retest reliability. This research has also compared DISE findings to those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not responded to previous sleep apnea surgery. The... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: UCLA Santa Monica Medical Center, Santa Monica, California
Conditions: Sleep Apnea, Obstructive
Product Surveillance Registry
Recruiting
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.
Gender:
ALL
Ages:
All
Trial Updated:
07/24/2025
Locations: Not set, Birmingham, Alabama +381 locations
Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency, Neurovascular, Coronary Artery Disease, Ear, Nose and Throat Disorder
Genetics of Insulin and Incretins in Cystic Fibrosis
Recruiting
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
07/24/2025
Locations: The Children's Hopsital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Cystic Fibrosis
The Effects of Sleep on Human Microbiota: Implications for Health and Disease
Recruiting
The aggregate of microorganisms inhabiting the human body can be regarded as a dynamic reflector of both healthy and disease states, altering in response to changes in the environment. This may precede clinically detectable disease; and thereby, could be used to predict disease onset and additionally monitor response to treatment and predict prognosis. The primary hypothesis of this pilot study is that the human microbial communities are influenced by sleep and altered in humans with abnormal sl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Sleep
Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment
Recruiting
The purpose of the study is to test the hypothesis that functionally navigated repetitive TMS stimulations to the prefrontal cortex (PFC) modulate aberrant cortical electrical activities at PFC circuitry. The TMS location of the PFC site will be individually localized by the symptom-related functional connectivity between PFC and symptom related areas (such as the auditory and language processing cortex). The investigators predict that such modulation will correct abnormal activities in patients... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/24/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Schizophrenia and Related Disorders
The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).
Recruiting
The purpose of this study is to assess the safety and effectiveness of the Artisse™ Intrasaccular Device in the treatment of unruptured and ruptured wide-neck bifurcating intracranial aneurysms.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/24/2025
Locations: Baptist Medical Center Jacksonville, Jacksonville, Florida +8 locations
Conditions: Intracranial Aneurysm
Medtronic Terminate AF Study
Recruiting
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal atrial fibrillation (AF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Stanford Hospitals and Clinic, Palo Alto, California +14 locations
Conditions: Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation