Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
NCT06215586
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Cardurion Investigative Site, Birmingham, Alabama +75 locations
Conditions: Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
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A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
NCT06292780
Recruiting
This study is researching an experimental drug called linvoseltamab ("study drug"). This study is focused on patients who have AL amyloidosis that has returned or have failed other therapies and need to be treated again. The study consists of 2 phases (Phase 1 and Phase 2): * In Phase 1, linvoseltamab will be given to a small number of participants to study the side effects of the study drug and to determine the recommended doses of the study drug to be given to participants in Phase 2. * In... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: City of Hope, Duarte, California +15 locations
Conditions: Relapsed/Refractory Systemic Light Chain Amyloidosis
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Food Insecurity Reduction & Strategy Team
NCT06329375
Recruiting
This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1. To describe the social-demographic and clinical factors associated with food insecurity in the hospitalized diabetic population. 2. To design, implement and evaluate a nutrition program targeting the hospitalized diabetic population. The investigators will prospectively random... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Stanford Medicine, Palo Alto, California
Conditions: Diabetes Mellitus, Type 2, Food Insecurity, Diabetes Mellitus, Type 1
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Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers
NCT06422767
Recruiting
This study will evaluate the effect of a single dose of bepirovirsen on the QT interval corrected by Fridericia's formula (QTcF) as compared to placebo. The data generated will be used to model the relationship between bepirovirsen concentration and QTcF.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/14/2025
Locations: GSK Investigational Site, Austin, Texas
Conditions: Hepatitis B
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The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)
NCT06524856
Recruiting
Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health. The Lung Master is not approved by the FDA. The study has two visits approximately one month apart. In the first visit participants will take a spirometry test, particularly forced vital capacity (FVC), to measure volume change in the lungs. Participants will take the investiga... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
04/14/2025
Locations: Biomechanics Research Building, Omaha, Nebraska
Conditions: Dyspnea, Chronic Obstructive Pulmonary Disease, Asthma
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Kidney Function in People With Cystic Fibrosis in the Era of HEMT
NCT06595420
Recruiting
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it becomes permanent. The study will compare these markers in people with CF over time and during the treatment of lung flare-ups. It will also compare the blood and urine samples obtained from people without CF. The comparison aims to better understand the impact of cystic... Read More
Gender:
ALL
Ages:
7 years and above
Trial Updated:
04/14/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +2 locations
Conditions: Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
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The Effects of Cannabidiol on the Driving Performance of Healthy Adults by Dose and Sex
NCT06686914
Recruiting
The objectives/purpose of this study are to comprehensively investigate the effects of non-prescription CBD on driving performance, drowsiness, sedation, and cognitive function in a large sample of healthy adults aged 18-30 years, with additional characterization of effects by dose and by sex, using a rigorous RCT design which will naturally mitigate confounding factors.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/14/2025
Locations: West Virginia University, Morgantown, West Virginia
Conditions: Cannabidiol Effects, Driving Performance
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Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs)
NCT06784063
Recruiting
The purpose of this study is to generate clinical data to quantify the impact of residual astigmatism on the overall visual performance during distance, intermediate, and near viewing in patients implanted with Clareon Vivity IOLs.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/14/2025
Locations: Grosinger, Spigelman & Grey Eye Surgeons, P.C, Bloomfield Hills, Michigan +2 locations
Conditions: Astigmatism
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Internet-based Talking About Risk and Adolescent Choices: Health and Emotion Regulation Options
NCT06894277
Recruiting
Using the efficacious iTRAC intervention to enhance emotion regulation competencies as a foundation, this study will create and test iTRAC-HERO to teach emotion regulation skills in the context of sexual health education.
Gender:
ALL
Ages:
Between 12 years and 14 years
Trial Updated:
04/14/2025
Locations: Klein Buendel, Inc., Golden, Colorado
Conditions: Risky Sexual Behavior, Emotion Regulation, Adolescent Behavior
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Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
NCT06937970
Recruiting
This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Mayo Clinic, Phoenix, Arizona +23 locations
Conditions: Mesothelioma, Non Small Cell Lung Cancer, Malignant Peripheral Nerve Sheath Tumors, Solid Tumor, Pancreatic Adenocarcinoma, Advanced Solid Tumor
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The Natural History Study of Mitochondrial NeuroGastroIntestinal Encephalopathy (MNGIE)
NCT01694953
Recruiting
This is a multi-center natural history study of Mitochondrial NeurogastroIntestinal Encephalopathy (MNGIE). Patients will be followed over time to assess clinical symptoms. The investigators hope to learn more about the disease of MNGIE as well as develop useful measures of disease status for use in future clinical trials. Additional clinical centers will be listed as they become available.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
04/14/2025
Locations: Columbia University, New York, New York
Conditions: Mitochondrial NeuroGastroIntestinal Encephalopathy (MNGIE)
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A Phase 1/2 Study of [225Ac]-FPI-1434 Injection
NCT03746431
Recruiting
This is a first-in-human Phase 1/2, non-randomized, multi-centre, open-label clinical study designed to investigate safety, tolerability, PK, and preliminary anti-tumour activity of \[225Ac\]-FPI-1434 (radioimmuno-therapeutic agent) in patients with solid tumours that demonstrate uptake of \[111In\]-FPI-1547 (radioimmuno-imaging agent), and to establish the maximum tolerated dose (MTD) and/or the recommended Phase 2 dose (RP2D) of repeat doses of \[225Ac\]-FPI-1434 Injection in patients with sol... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: City of Hope, Duarte, California +12 locations
Conditions: Advanced Solid Tumours, Endometrial Cancer, Cervical Cancer, Ovarian Cancer, Breast Cancer, Triple Negative Breast Cancer (TNBC), HER2-negative Breast Cancer, Head and Neck Squamous Cell Carcinoma (HNSCC), Adrenocortical Carcinoma, Uveal Melanoma
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