A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Recruiting
The purpose of this study is to evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: UCLA Healthcare Hematology-Oncology, Santa Monica, California +8 locations
Conditions: Solid Tumors
Mixed Vs Blocked Search: Four Unique Tasks
Recruiting
The goal is to look for qualitative differences in visual search behavior when one search is performed many times in a row compared to when multiple search tasks are intermixed. Four search tasks are tested. In the Mixed condition, the four tasks are randomly changed from trial to trial. In the Blocked condition, each task is run as a block of 100 trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Vision, Healthy, Attention
Surveillance Versus Bronchoscopy After Airway Stenting
Recruiting
Randomized, pilot study that evaluates surveillance bronchoscopy versus no surveillance for patients that undergo tracheobronchial stenting
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: The Mount Sinai Health System, New York, New York
Conditions: Bronchial Stents
Effects of External Ear Stimulation on Pain Perception and Mood
Recruiting
Background: The vagus nerve runs from the brain to many organs. Stimulating it can affect the experience of pain. The nerve can be stimulated on the surface of the left ear. Researchers want to study how this stimulation affects the perception of pain. They also want to study how mood affects the experience of pain. Objective: To study the effects of mood and vagus nerve stimulation on the experience of pain. Eligibility: Healthy people ages 18 and older who are fluent in English Design:... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/11/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pain in Healthy Participants
Neurocognitive Decline in Patients With Brain Metastases
Recruiting
The phase I component of the study is to identify maximal tolerated dose (MTD). The phase II is to evaluate neurocognitive decline.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Brain Metastases
Sleep Behaviors in Pregnancy
Recruiting
The researchers would like to know how long pregnant women spend in different positions during the night - and how often women change positions - across pregnancy. The researchers also want to see if the sleep monitor is able to improve sleep behaviors
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Sleep, Pregnancy Complications
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
Recruiting
The ELEGANCE Registry's objective is to collect Real-World Data (RWD), including populations previously not represented in Peripheral Vascular Disease (PVD) trials, health economics data, and to support the safe use of commercially available Boston Scientific Corporation (BSC) drug-eluting devices for the treatment of lesions located in the peripheral vasculature.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: St. Bernard's Medical Center, Jonesboro, Arkansas +77 locations
Conditions: Peripheral Vascular Diseases
SELUTION4BTK Trial
Recruiting
This study aims to demonstrate superior efficacy and equivalent safety of the SELUTION SLR™ DEB 014 compared to plain (uncoated) balloon angioplasty in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: St. Bernards Medical Center, Jonesboro, Arkansas +39 locations
Conditions: Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities
Study to Evaluate Percussive Ventilation Breathhold to Improve Lung Stereotactic Ablative Radiotherapy
Recruiting
The purpose of this research is to evaluate and determine the rate of successful administration of Percussive ventilation breathhold (PVB) to allow for more accurate radiotherapy for lung tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Stanford Cancer Institute, Palo Alto, California
Conditions: Lung Cancer
Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia
Recruiting
Changing the schedule of intrathecal chemotherapy to be given before and during blinatumomab will maintain the anti-leukemic effects of this drug while at the same time adding the benefit of limiting the neurotoxicity associated with cytokine release.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Northside Hospital, Atlanta, Georgia
Conditions: Acute Lymphoblastic Leukemia
Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)
Recruiting
This phase II ComboMATCH treatment trial tests how well AMG 510 (sotorasib) with or without panitumumab works in treating patients with KRAS G12C mutant solid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Sotorasib is in a class of medications called KRAS inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells. Pan... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +158 locations
Conditions: Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease
Recruiting
The objective of this prospective, multicenter, randomized, controlled clinical trial is to demonstrate the superiority of the VBX Device for primary patency when compared to bare metal stenting in complex iliac occlusive disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: North Suburban Medical Center, Denver, Colorado +6 locations
Conditions: Aortoiliac Occlusive Disease, Peripheral Arterial Disease