Tislelizumab in People With Colorectal Cancer
NCT06529523
Recruiting
The researchers are doing this study to find out whether tislelizumab is an effective treatment for people with colorectal cancer who are living in Nigeria. The researchers will also look at the safety of the study drug. All participants in this study will be treatment naïve (they have not yet received treatment for their cancer), and their cancer will be mismatch repair deficient (dMMR). dMMR cancer can happen when your cells are unable to repair mistakes made during the cell division process. Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York +2 locations
Conditions: Colorectal Cancer
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A Study to Assess the Potential for Airway Sensitivity Reactions With Propellants HFA-152a (Test) and HFA-134a (Reference) Administered Via Pressurized Inhalers in Adults With Mild Asthma
NCT06702462
Recruiting
The purpose of the study is to assess the propellants,1 - Difluoroethane \[HFA-152a\] (Test) and 1,1,1,2-Tetrafluoroethane \[HFA-134a\] (Reference) for their potential to cause the airways to tighten when delivered through pressurized metered dose inhalers (pMDI). The rationale for this study is to develop a low carbon footprint alternative propellant, HFA-152a, which will have a lower impact on global warming.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
04/02/2025
Locations: GSK Investigational Site, San Antonio, Texas
Conditions: Asthma
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MOTION Clinical Trial
NCT06843980
Recruiting
Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment. This is the first randomized head-to-head study comparing outcomes from subjects treated with the MISHA Knee System.
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: Scripps Clinic Jefferson, Oceanside, California +3 locations
Conditions: Osteoarthritis, Knee
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Breastfeeding Peer Counseling Intervention for Latine Families
NCT06921382
Recruiting
The goal of this clinical trial is to learn how to improve exclusive breastfeeding rates in the Latine community. Breastfeeding initiation is high in this community, but many people ultimately do not breastfeed for as long as they would like to. The main questions it aims to answer are: Do Latine mothers benefit from peer counseling support from peer counselors who can speak Spanish and share their cultural background? Are mothers more likely to continue exclusive breastfeeding if additional fu... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: WIC Guilford County, Greensboro, North Carolina +1 locations
Conditions: Breastfeeding Self-Efficacy, Breastfeeding Continuation, Breastfeeding Duration, Breastfeeding Support
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Feasibility Study to Treat Lung Cancer With the Permanently Implantable LDR CivaSheet®
NCT03290534
Recruiting
This is a feasibility study to determine the usefulness of a brachytherapy device that utilizes active components (palladium-103) of standard devices in a novel configuration, which may benefit lung cancer patients by reducing the radiation dose to critical structures, such as the heart wall, while giving a therapeutic dose to diseased tissue, such as at a surgical margin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: NYU Langone Health, New York, New York
Conditions: Lung Cancer, Lung Cancer Stage I, Lung Cancer Stage II
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Telehealth and Memory Study
NCT04586530
Recruiting
The overall purpose of this trial is to confirm the efficacy of Memory and Attention Adaptation Training (MAAT), a cognitive-behavioral therapy (CBT) for treatment of chemotherapy-related cognitive dysfunction among (female or male) breast cancer survivors. This is a multi-center, multi-clinician randomized control trial (MAAT vs. supportive therapy attention control condition). This trial will also evaluate a sub-sample of survivors pre-and post treatment with functional magnetic resonance imag... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Indiana University, Indianapolis, Indiana +1 locations
Conditions: Chemotherapy-related Cognitive Dysfunction
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Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes
NCT05041491
Recruiting
Newly released guidelines recommend increased physical activity (PA) and reduced sedentary behaviors (SB) to improve glycemia and prevent the onset and progression of type 2 diabetes (T2D). Typically, 30-60 min bouts of PA are advocated per day. Although this approach increases PA, it does not decrease the length of the sedentary periods through the day. This is important because recent epidemiological data suggest that frequently interrupting sedentary time improves glucose control even in peop... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/02/2025
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Pre-diabetes
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A Study of Daratumumab
NCT05438043
Recruiting
The purpose of this study is to provide ongoing access to study treatments for participants with multiple myeloma or smoldering multiple myeloma benefiting from treatment in certain Janssen Research and Development (R\&D) studies that use daratumumab as part of the study treatment regimen: access for all participants regardless of treatment group in daratumumab studies and access to participants in daratumumab-containing arms in the non-daratumumab studies will be allowed from studies which have... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of Miami Sylvester Cancer Center, Miami, Florida +75 locations
Conditions: Multiple Myeloma
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NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
NCT05674799
Recruiting
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years. The investigators will recruit 360 women aged 18-39 years with overweight/obesity who are not currently pregnant, but likely to conceive within 24 months. Women will be randomized to NDPP-NextGen or a usual care control group. The NDPP-NextGen group will participate in the adapted NDPP online group class across 12 months,... Read More
Gender:
FEMALE
Ages:
Between 18 years and 39 years
Trial Updated:
04/02/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Overweight or Obesity
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Ovarian Tissue Cryopreservation for Fertility Preservation
NCT05875155
Recruiting
The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation. In addition, this study will provide research tissue for the following Specific Aims: 1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting... Read More
Gender:
FEMALE
Ages:
39 years and below
Trial Updated:
04/02/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Cancer, Autoimmune Diseases
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Preschool Hearing Screening
NCT06058767
Recruiting
Children who are deaf or hard-of-hearing (D/HH) are at risk of speech and language delays, which can be mitigated through early identification and intervention. Identifying hearing loss (HL) during preschool is crucial, but the most effective hearing screening method for preschoolers remains uncertain. The purpose of this study is to learn whether, compared to the gold-standard two-stage Pure-tone audiometry (PTA) + otoacoustic emissions (OAE) screening (TS-PO), single-stage OAE (SS-O) screening... Read More
Gender:
ALL
Ages:
Between 2 years and 6 years
Trial Updated:
04/02/2025
Locations: The University of California, San Francisco, San Francisco, California
Conditions: Hearing Loss, Hearing Disorders in Children, Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Unilateral, Hearing Loss, Noise-Induced, Hearing Loss, Mixed, Hearing Loss, Bilateral
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Pediatric Oncology Nutrition Intervention Trial
NCT06175273
Recruiting
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a combination of disease burden, side effects of chemotherapy, and the intensity of cancer treatment. These patients are known to have an increased risk of infection, treatment-related toxicity, inferior clinical outcomes, and increased risk of mortality. Malnutrition may progress to cancer cachexia, characterized by anorexia, increased inflammation, decreased fat, and decreased muscle mass with subsequent weig... Read More
Gender:
ALL
Ages:
Between 2 years and 19 years
Trial Updated:
04/02/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Pediatric Cancer, Nutrition Related Cancer, Nutrition Aspect of Cancer, Muscle Loss, Malnutrition, Child
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