Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652
Recruiting
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death and HF events.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
04/03/2025
Locations: Research Site, Alexander City, Alabama +739 locations
Conditions: Heart Failure and Impaired Kidney Function
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A Study of RhinAer Stylus for Treating Chronic Rhinitis
NCT06599736
Recruiting
Post-market study to continue to evaluate the effectiveness of the RhinAer Stylus for chronic rhinitis and the effect of treatment on inflammatory biomarkers.
Gender:
ALL
Ages:
Between 22 years and 85 years
Trial Updated:
04/03/2025
Locations: Colorado ENT & Allergy, Colorado Springs, Colorado
Conditions: Chronic Rhinitis
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CIPN Decision Aid for the Improvement of Chemotherapy Decision Making in Patients With Breast Cancer
NCT06915168
Recruiting
This clinical trial studies how well a chemotherapy-induced peripheral neuropathy (CIPN) decision aid works in improving chemotherapy decision making among patients with breast cancer. CIPN involves numbness or tingling in the hands or feet and is a debilitating side effect of several commonly used classes of cancer drugs. CIPN symptoms are typically minor at first but can progress with continued treatment to severe symptoms that can affect long-term function, falls risk, and quality of life. Sy... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/03/2025
Locations: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Breast Carcinoma
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Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury
NCT02577731
Recruiting
Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden. Despite decades of promising preclinical and clinical investigations in trauma, investigators understanding of these entities is still incomplete, and few therapies have shown success. During severe trauma, bone marrow granulocyte stores are rapidly released into the peripheral circulation. This release subsequently induces the expansion and repopulation of e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: UF Health Shands Hospital at the University of Florida, Gainesville, Florida
Conditions: Trauma Injury
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WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)
NCT04701684
Recruiting
The WE-TRUST study is a multi-center randomized clinical trial to assess the impact of a Direct to Angio Suite (DTAS) workflow on stroke patient outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Baptist Medical Center, Jacksonville, Florida +19 locations
Conditions: Stroke, Acute
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Modified Immune Cells (TAG72-CAR T Cells) for the Treatment of Patients With Platinum Resistant Epithelial Ovarian Cancer
NCT05225363
Recruiting
This phase I trial tests the safety, side effects, and best dose of TAG72-chimeric antigen receptor (CAR) T cells in treating patients with epithelial ovarian cancer that remains despite treatment with platinum therapy (platinum resistant). T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize TAG72, a protein on the surface of tumor cells. These TAG72... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Platinum-Resistant Ovarian Carcinoma
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FEED-Cystic Fibrosis (FEED-CF)
NCT05766774
Recruiting
The goal of this study is to determine the extent to which excess dietary sugars serve as a precipitating factor in glucose intolerance in adults with cystic fibrosis (CF), a population at especially high risk for a unique form of diabetes (CF-related diabetes, CFRD) and with standard-of-care dietary recommendations (high-calorie, high-fat) that conflict with recommendations for other forms of diabetes. This trial will investigate if the typical high-sugar, high-fat CF diet plays a role in diab... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Cystic Fibrosis, Cystic Fibrosis-related Diabetes
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National Liver Cancer Screening Trial
NCT06084234
Recruiting
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), an... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/03/2025
Locations: University of Southern California, Los Angeles, California +13 locations
Conditions: Carcinoma, Hepatocellular, Liver Cancer, Liver Cirrhosis, Hepatitis B
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Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study of PORT-77 Administered to Healthy Adult Participants
NCT06346509
Recruiting
A First-in-Human 2-part, randomized, double-blind, placebo-controlled, single ascending dose, multiple ascending dose, and food effect, investigation of the administration of PORT-77 in healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/03/2025
Locations: Celerion, Tempe, Arizona
Conditions: Healthy Adult Participants
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A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of Age
NCT06602024
Recruiting
The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1010, and to evaluate relative vaccine efficacy (rVE) of mRNA-1010 versus an active comparator against reverse transcription polymerase chain reaction (RT-PCR)-confirmed protocol-defined influenza-like illness (ILI) caused by any influenza A or B strains.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/03/2025
Locations: Pinnacle Research Group, Llc, Anniston, Alabama +309 locations
Conditions: Seasonal Influenza
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YAG Laser Vitreolysis for Vitreous Floaters
NCT06915922
Recruiting
The purpose of this study is to measure how the quality of life, the structure of eye, and vision change after treatment for the opacities in the gel (vitreous) that fills the center of eye which cause vision disturbances commonly called "floaters". In this study the vitreous floaters are treated using a Neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser. The FDA has approved the use of this laser to treat membranes in the eye.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: VMR Institute for Vitreous Macula Retina, Huntington Beach, California
Conditions: Posterior Vitreous Detachment, Myopic Vitreopathy, VISION DEGRADING MYODESOPSIA
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Measurement of Energy Metabolism in Infants
NCT02683473
Recruiting
The purpose of this study is to measure energy expenditure during the first 3 months of life in infants.
Gender:
ALL
Ages:
Between 1 month and 3 months
Trial Updated:
04/03/2025
Locations: Pennington Biomedical Research Center, Baton Rouge, Louisiana
Conditions: Infant Development, Infant Overnutrition
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