Study of Obeldesivir to Treat Children With Respiratory Syncytial Virus (RSV) Infection
NCT06784973
Recruiting
The goal of this clinical study is to check if obeldesivir (ODV; GS-5245) is safe and well-tolerated by children with respiratory syncytial virus (RSV) infection. It will also look at how well ODV helps reduce the time it takes for children to feel better and for their RSV symptoms to improve. The primary objectives of this study are: a) to evaluate the safety and tolerability of ODV in pediatric participants with RSV infection; b) To evaluate the efficacy of ODV on time to alleviation of targe... Read More
Gender:
ALL
Ages:
5 years and below
Trial Updated:
04/14/2025
Locations: Midway Medical Clinic, Oneonta, Alabama +52 locations
Conditions: RSV Infection
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Smart-Phone Safety Behavior Fading Intervention for Appearance Concerns (Open ARSB Study)
NCT06896435
Recruiting
The current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a relaxing video intervention for appearance concerns.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/14/2025
Locations: Florida State University, Tallahassee, Florida
Conditions: Body Dysmorphic Disorder, Social Anxiety Disorder, Eating Disorders
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Pilot Haskap Metabolite Timing Project
NCT06938386
Recruiting
Diet is a key factor in managing health and individuals at risk of developing metabolic syndrome or other chronic diseases have the opportunity to use diet as a tool to improve their health. This can be complicated when considering the numerous variables that impact digestion and absorption of key health-promoting compounds in foods. One of these variables is the gut microbiome, a microbial community in the digestive tract that interacts with the foods we consume. The mechanisms the microbiome u... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
04/14/2025
Locations: Montana State University, Bozeman, Montana
Conditions: Microbial Colonization, Metabolic Disease, Digestion
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A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies
NCT02651662
Recruiting
This study is researching a combination of 2 experimental drugs, referred to as "study drugs", called odronextamab (also known as REGN1979) and cemiplimab (also known as REGN2810). The study is focused on patients who have relapse/refractory aggressive B-cell lymphoma. The aim of the study is to see how safe and tolerable the study drugs are, and to define the recommended dose regimen for the combination with odronextamab. This study is also looking at several other research questions, includin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: University of California Los Angeles Medical Center, Santa Monica, California +38 locations
Conditions: Relapsed/Refractory Aggressive B-Cell Lymphoma
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The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
NCT03845036
Recruiting
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the DASH dietary program combined with a home-based exercise program, quantified by a step activity monitor, to improve exercise and vascular outcome measures in patients with PAD.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/14/2025
Locations: O'Donoghue Research Building, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Claudication, Peripheral Artery Disease
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Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma
NCT04659811
Recruiting
This phase II trial studies the effect of stereotactic radiosurgery and pembrolizumab in treating patients with meningioma that has come back (recurrent). Stereotactic radiosurgery is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. It is used to treat brain tumors and other brain disorders that cannot be treated by regular surgery. Pembrolizumab is a humanized monoclonal antibody. An antibody... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Grade I Meningioma, Adult, Grade II Meningioma, Adult, Grade III Meningioma, Adult, Recurrent Meningioma
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Comparison of Bracing With Co-aptation Splinting for the Initial Treatment of Acute Humeral Shaft Fractures: The COBRAS Trials
NCT05118087
Recruiting
The goal of this study is to determine which initial method of immobilization for humeral shaft fractures in the emergency room maximizes patient comfort. The two methods of initial management for humeral shaft fractures are sarmiento bracing (pre-fabricated fracture brace) and coaptation splinting. In this study, the team will compare patient related outcomes and comfort for each method of initial management of humeral shaft fractures. Participant pain, narcotic usage, and function will be trac... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: NYU Winthrop Hospital, Garden City, New York +2 locations
Conditions: Humeral Fractures
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The Cardiovascular Impact of Hot Flushes
NCT05251324
Recruiting
The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asympto... Read More
Gender:
FEMALE
Ages:
Between 40 years and 70 years
Trial Updated:
04/14/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hot Flashes, Menopause
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Upper Extremity Life Care Specialist (LCS)
NCT05422014
Recruiting
This is a randomized control trial aimed at learning more about LCS position and the value it provides to the patient's who have sustained upper extremity traumas.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Grady Memorial Hospital, Atlanta, Georgia
Conditions: Upper Extremity Trauma
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Polypill in Acute Coronary Syndrome
NCT05514938
Recruiting
Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low. This contributes to worse patient outcomes and increased risk of morbidity and mortality. The once-daily polypill leverages a population-based strategy that has previously demonstrated efficacy in improving adherence and access to therapy in low-resource settings, making it an innovative approach for improving post-ACS ca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease
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Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant
NCT05613010
Recruiting
Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobile technology intervention uses real-time electronic pillbox-assessed dose timing and text message prompts to address antirejection medication nonadherence when nonadherence is detected.
Gender:
ALL
Ages:
Between 13 years and 25 years
Trial Updated:
04/14/2025
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Transplant;Failure,Kidney, Transplant; Failure, Liver, Adherence, Medication, Adherence, Patient, Adherence, Treatment
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A Study of ADCLEC.syn1 in People With Acute Myeloid Leukemia
NCT05748197
Recruiting
The purpose of this study is to test the safety of ADCLEC.syn1 CAR T cells in people with relapsed or refractory AML. The researchers will try to find the highest dose of ADCLEC.syn1 CAR T cells that causes few or mild side effects in participants. Once the researchers find this dose, it will test it in a new group of participants to see if it is effective in treating their relapsed/refractory AML.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Acute Myeloid Leukemia
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