A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
NCT06565195
Recruiting
The purpose of this study is to evaluate the safety, tolerability, and PK/PD of LY3962681 in healthy volunteers and patients with Parkinson's disease. The study will be comprised of two parts, the Single Ascending Dose (SAD) study and the Multiple Ascending Doses (MAD) study. During the SAD portion of the study, healthy volunteers will receive a single dose of LY3962681 or placebo (artificial cerebrospinal fluid (aCSF), no active drug) given into the spinal fluid. During the MAD portion of the... Read More
Gender:
ALL
Ages:
Between 30 years and 80 years
Trial Updated:
03/24/2025
Locations: Austin Clinic PPD, Austin, Texas +1 locations
Conditions: Parkinson's Disease
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My Health Coach App RCT
NCT06638463
Recruiting
The goal of this clinical trial is to learn if the My Health Coach app helps adults with fetal alcohol spectrum disorders (FASD). The main questions it aims to answer are: Does the My Health Coach app improve the quality of life of adults with FASD? Does the My Health Coach app help adults with FASD manage their day to day life? All participants will be asked to complete 3 sets of surveys: 1) at the study start, 2) at 6 weeks, and 3) at 12 weeks. Half of the participants will be given the app... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of Rochester, Rochester, New York
Conditions: Fetal Alcohol Spectrum Disorders
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Assessment of Safety and Accuracy of the Microtech System in Patients Undergoing Left Ventricular Assist Device Implantation
NCT06682910
Recruiting
The Microtech-LVAD study is designed as a prospective, single arm, multi-center early feasibility study. Approximately 15 patients will be enrolled in the study. The study will be limited to patients in whom it is decided, based on routine clinical practice, that the LVAD will be implanted via a midline sternotomy. In the first 5 study patients, the device will be implanted in the RA; subsequently, the device will be implanted in the LA unless the patient is deemed at high risk of post-LVAD righ... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/24/2025
Locations: Columbia University Medical Center/ NewYork Presbyterian Hospital or CUMC/NYPH, New York, New York +1 locations
Conditions: Heart Failure
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An Ophthalmic Safety Study in Patients With Breast Cancer
NCT06767462
Recruiting
To assess ophthalmic health in parallel cohorts of patients with breast cancer
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
03/24/2025
Locations: Research Site, La Jolla, California +71 locations
Conditions: Ophthalmic Safety in Patients With Breast Cancer
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Early Intervention in High Risk CCUS
NCT06802146
Recruiting
This research is being done to find out more about the potential risks and benefits of early treatment in participants with high risk Clonal Cytopenia of Unknown Significance (CCUS). This study will give eligible CCUS participants the option of either being observed or taking an oral drug as treatment. The names of the study drug involved in this study is: -Decitabine/cedazuridine (DEC/CED) (a nucleoside metabolic inhibitor and cytidine deaminase inhibitor).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Clonal Cytopenia of Undetermined Significance, Cytopenia
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Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction
NCT06831149
Recruiting
Investigators performing this research want to look at the use of a special imaging process during a specific throat surgery. Using this imaging may help to lower a common complication that called a pharyngocutaneous fistula (PCF). A PCF is a leak in the tube in the throat that helps with breathing and digesting food. The imaging is called the SPY Fluorescence System. This system can identify tissue that is not receiving enough blood. The SPY Fluorescence System uses a special dye, called Indoc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Squamous Cell Carcinoma, Pharyngocutaneous Fistula
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Stimulating the Cochlear Apex Without Longer Electrodes
NCT06901674
Recruiting
The most common cochlear implant intervention provides an electrode array that stimulates less than half of the length of the cochlea, leaving the regions which represent lower frequencies in the normally functioning ear unstimulated. Providing stimulation over the entire cochlea has the potential to improve speech understanding, sound quality, as well as spectral and temporal representation. Increasing the length of the electrode array to cover a greater portion of the cochlea has many potentia... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/24/2025
Locations: NYU Langone Health, New York, New York
Conditions: Deafness With a Cochlear Implant
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Inherited Retinal Degenerative Disease Registry
NCT02435940
Recruiting
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation. It is a patient-initiated registry accessible via a secure on-line portal at www.MyRetinaTracker.org. Affected individuals who register are guided to create a profile that captures their perspective on their retinal disease and its progress; family history; genetic testing results; preventive measures; g... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/24/2025
Locations: Foundation Fighting Blindness, Columbia, Maryland
Conditions: Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome, Bassen-Kornzweig Syndrome, Batten Disease, Best Disease, Choroidal Dystrophy, Choroideremia, Cone Dystrophy, Cone-Rod Dystrophy, Congenital Stationary Night Blindness, Enhanced S-Cone Syndrome, Fundus Albipunctatus, Goldmann-Favre Syndrome, Gyrate Atrophy, Juvenile Macular Degeneration, Kearns-Sayre Syndrome, Leber Congenital Amaurosis, Refsum Syndrome, Retinitis Pigmentosa, Retinitis Punctata Albescens, Retinoschisis, Rod-Cone Dystrophy, Rod Dystrophy, Rod Monochromacy, Stargardt Disease, Usher Syndrome
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Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C
NCT03471143
Recruiting
Niemann-Pick disease, type C (NPC) is a lethal, autosomal recessive, lysosomal storage disorder characterized by neurodegeneration in early childhood and death in adolescence. NPC results from mutation of either the Niemann-Pick C1 disease (NPC1) (\~95% of cases) or NPC2 genes. NPC is characterized by the endolysosomal storage of unesterified cholesterol and lipids in both the central nervous system and peripheral tissues such as the liver. Individuals with NPC demonstrate progressive central ne... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
03/24/2025
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Niemann-Pick Disease, Type C
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Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer
NCT03922893
Recruiting
This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.
Gender:
ALL
Ages:
All
Trial Updated:
03/24/2025
Locations: Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey +6 locations
Conditions: Cancer
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In-Utero Endoscopic Correction of Spina Bifida
NCT04362592
Recruiting
The purpose of this study is to evaluate the feasibility and effectiveness of performing fetoscopic surgical correction of fetal spina bifida. Two surgical approaches will be utilized: the percutaneous technique versus the laparotomy/uterine exteriorization technique.
Gender:
FEMALE
Ages:
Between 18 years and 52 years
Trial Updated:
03/24/2025
Locations: Hollywood Presbyterian Medical Center, Los Angeles, California +1 locations
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele
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Early-Line Anti-EGFR Therapy to Facilitate Retreatment for Select Patients With mCRC
NCT04587128
Recruiting
The study will use previously established doses of panitumumab or cetuximab in the metastatic setting for the treatment of unresectable colorectal cancer (CRC). It is designed to investigate an alternative treatment strategy to maximize the benefit to inhibition of epidermal growth factor receptor (EGFR) for a highly selected patient population. It will enroll 71 participants with left-sided, unresectable metastatic CRC. Participants will be on study up to 5 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Metastatic Colorectal Cancer
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