Breathing & Blood Pressure
Recruiting
The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
05/06/2025
Locations: Florida State University, Tallahassee, Florida
Conditions: Healthy, Overweight and Obesity
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Recruiting
The purpose of this study is to test if the combination of ketamine, vs midazolam, with an intensive trauma-focused psychotherapy will be more effective in relieving post-traumatic stress disorder (PTSD). This week-long treatment has the potential to produce a significant therapeutic effect that otherwise would take months to occur. The study will also focus on learning about the neurophysiological changes produced by the proposed clinical trial.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/06/2025
Locations: Yale University School of Medicine, New Haven, Connecticut +1 locations
Conditions: Posttraumatic Stress Disorder
The Goodnight Screen Media Study
Recruiting
To test the timing of evening tablet use on children's circadian phase and sleep (i.e., sleep onset and sleep duration) compared to no screen media use. To explore the effect of evening tablet use on children's inhibitory control and executive function.
Gender:
ALL
Ages:
Between 48 months and 59 months
Trial Updated:
05/06/2025
Locations: Children's Nutrition Research Center, Houston, Texas
Conditions: Sleep, Sleep Hygiene
Peru Decentralized HIV Care
Recruiting
The purpose of this study is to understand the processes by which HIV care is decentralized, an evidence-informed strategy to improve retention in HIV care, in Peru. Decentralization of HIV services has not been evaluated using experimental designs and urban decentralization studies of HIV are uncommon, so this study will lend important insights for future decentralization efforts in Peru and other countries.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Yale University, New Haven, Connecticut +1 locations
Conditions: HIV
An Observational Research Study to Uncover Subtypes of Cancer Cachexia
Recruiting
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable). Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Mercy Hospital Fort Smith, Ft. Smith, Arkansas +194 locations
Conditions: Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Colorectal Carcinoma, Unresectable Lung Non-Small Cell Carcinoma, Unresectable Pancreatic Adenocarcinoma
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
Recruiting
This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.
Gender:
ALL
Ages:
Between 25 years and 50 years
Trial Updated:
05/06/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Depressive Disorder, Major, Inflammation
A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers.
Recruiting
The purpose of this trial is to assess the safety, tolerability and between-group effect size of STIMULAN VG (with debridement) and a course of systemic antibiotics to standard of care (debridement and systemic antibiotics only) for the treatment of osteomyelitis associated stage IV pressure ulcers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: NYU Langone Hospital - Long Island Clinical Research Center, Mineola, New York
Conditions: Pressure Ulcer, Stage IV, Osteomyelitis
Exercise Prehabilitation for Locoregional Esophageal Cancer
Recruiting
The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Esophageal Cancer
A Study to Investigate the Effect on Lung Function of BDA Formulated With a New Propellant (HFO) Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With Asthma
Recruiting
The purpose of this study is to assess the PD equivalence of the approved asthma combination therapy, BDA, delivered using the proposed replacement propellant HFO compared with BDA delivered using the currently approved propellant HFA in participants with asthma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Research Site, Mobile, Alabama +135 locations
Conditions: Asthma
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
Recruiting
* To perform metabolic phenotyping of treatment naïve and recurrent GBM by multitracer \[18F\]Fluciclovine and 18F-FDG PET. * To compare uptake measures of 18F-Fluciclovine and 18F-FDG and MRI quantification of glutamate and lactate levels to tumor tissue laboratory assays (RNA seq and proteomics) of glutamine/glutamate, glucose, and lactate metabolism. * To perform metabolic phenotyping of treatment naïve and recurrent GBM by advanced MRI methods at 7 Tesla
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Glioblastoma, Recurrent Glioblastoma, Glioblastoma Multiforme of Brain
Immunologic Targeting of ESR1 Receptor for Hormone Receptor Expressing Metastatic Breast Cancer
Recruiting
This is a pilot study to determine feasibility and safety of the combination of Dendritic Cell (DC1) vaccines and elacestrant in patients with hormone positive HER2 negative metastatic breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Breast Cancer Metastatic Breast Cancer, HER2-negative Breast Cancer
mHealth-CArdiac REhabilitation for INOCA
Recruiting
This is a multi-site phase II, 2:1 pragmatic randomized trial of 250 participants within the NYU Langone Health (NYULH) and Emory University Medical Center system to evaluate mobile health cardiac rehabilitation (mHealth-CR) in patients who meet clinical criteria for INOCA (ischemia and no obstructive coronary disease on imaging). Participants will be randomized to mHealth-CR or usual care. The study intervention takes place for 3 months which is the time period for most traditional CR programs.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: NYU Langone Health, New York, New York
Conditions: Ischemia