Fertilo In Vitro Research Study and Trial
NCT06858111
Recruiting
The goal of this clinical trial is to evaluate the safety and efficacy of using Fertilo for In vitro maturation (IVM) in participants 18-35 years of age. The main question it aims to answer is whether the use of Fertilo is superior to using Medicult IVM for In vitro maturation. Researchers will compare the number of ongoing pregnancies at 12 weeks gestation for participants in each arm. * Arm 1 participants will have all cumulus oocyte complexes (COCs), or eggs surrounded by helper cells, cult... Read More
Gender:
FEMALE
Ages:
Between 18 years and 35 years
Trial Updated:
07/16/2025
Locations: Reproductive Fertility Center, Corona, California +10 locations
Conditions: In Vitro Maturation of Oocytes
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A Study to Evaluate INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors
NCT06873789
Recruiting
This study will be conducted to evaluate INCB177054 given as monotherapy or in combination with retifanlimab in participants with select advanced or metastatic solid Tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: The Angeles Clinic and Research Institute, Los Angeles, California +8 locations
Conditions: Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
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A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis.
NCT06899217
Recruiting
The goal of this clinical trial is to evaluate if the study drug CIN-102 (deudomperidone) can help to decrease nausea severity associated with idiopathic gastroparesis severity in adult subjects. The main questions it aims to answer are: * To evaluate the efficacy of CIN-102 on symptoms of gastroparesis when given to patients with idiopathic gastroparesis compared to a placebo * To evaluate the safety of CIN-102 when given to patients with idiopathic gastroparesis compared to a placebo Partic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: G & L Research, LLC, Foley, Alabama +71 locations
Conditions: Idiopathic Gastroparesis
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Comparison of New SUREcore Biopsy of Needle to Standard of Care During Transperineal Prostate Biopsies
NCT06907446
Recruiting
To study a novel biopsy needle system for performing transperineal prostate biopsy. Prostate biopsy remains the standard approach for prostate cancer detection. While pre-biopsy MRI allows for targeting of visible lesions, systemic or 'off target' samples are recommended due to the well-recognized risk of undegrading and under sampling with current commercially available needles. The SureCore plus single-use biopsy needle produces a more intact tissue core with a same caliber 18g needle with \~2... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: UC Davis Departments of Urologic Oncology, Sacramento, California
Conditions: Prostate Cancer
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Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes
NCT06923488
Recruiting
The goal of this interventional clinical trial is to evaluate the safety and tolerability of leflunomide in combination with decitabine as treatment for patients with relapsed or refractory myelodysplastic syndromes (R/R MDS). The main question this study aims to answer are to evaluate and estimate the maximum tolerated doses and/or biologically active doses of the combination of leflunomide-decitabine in participants. Decitabine will be administered at a dose of 20 mg/m2 by continuous intrave... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: West Virginia University Cancer Institute, Morgantown, West Virginia
Conditions: Myelodysplastic Syndromes
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Clinical Study of QRX003 Lotion in Subjects With Netherton Syndrome
NCT06953466
Recruiting
The goal of this clinical trial (via an expanded access Treatment Protocol) is to learn if QRX003 (an investigational drug) applied topically to the skin (including up to the entire body \[except the scalp\]) works to treat the genetic disease Netherton syndrome. It will also learn about the safety of QRX003. The main questions the trial aims to answer are: 1. Does QRX003 impact the clinical presentation of NS in adults and minors by improving the clinical symptoms (diseased skin area, itch, an... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
07/16/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Netherton Syndrome
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Skills for Talking About Cannabis for Families of Young Adults With Psychosis
NCT06961877
Recruiting
The objectives of this research is to (1) create a family intervention and provider manual to train family members of young people with psychosis (YP-P) who are heavy cannabis users new communication skills to motivate change in the YP-P's cannabis use, (2) pre-test the intervention with 10 family member participants and adapt the intervention based on their recommendations, and (3) evaluate the feasibility and acceptability of the intervention in a randomized pilot trial (n=40). The investigato... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: The University of Washington, Seattle, Washington
Conditions: Caregiver Burden, Cannabis Use, Expressed Emotion, Communications Skills
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Music Use in Parturients Admitted to Labor & Delivery
NCT06969105
Recruiting
The goal of this clinical trial is to learn if music use affects anxiety or pain levels in parturients admitted to labor and delivery. It will also learn about the effect of music use on patient satisfaction. The main questions it aims to answer are: Does music use affect anxiety levels in parturients admitted to labor and delivery? Does music use affect pain levels in parturients admitted to labor and delivery? Does music use affect patient satisfaction in parturients admitted to labor and del... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Anxiety, Pain, Patient Satisfaction
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Study With Phage for CF Subjects With Pseudomonas Lung Infection
NCT06998043
Recruiting
The goal of this Phase 2b clinical trial is to see if nebulized phage (BX004) can treat chronic Pseudomonas aeruginosa (PsA) lung infection in CF subjects. The primary goal is to see if 8 weeks of twice daily BX004 can reduce the amount of PsA in the sputum compared to placebo (on top of background CF therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +13 locations
Conditions: Chronic Pseudomonas Aeruginosa Infection, Cystic Fibrosis (CF)
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Post-Operative Analgesic Selection in Patients Planned for Third Molar Extraction After Undergoing Shared Decision Making Using 2- Versus 3-Option Decision-Aids
NCT07011472
Recruiting
This research protocol is exploring a behavioral intervention: shared decision making with the use of a decision aid to select a post-operative analgesic. Specifically, the investigators will examine the impact of shared decision making on analgesic selection for acute pain management when 2 options are presented to the patient as compared to 3 options which includes an opioid prescription for "just-in-case" pain management. The investigators hypothesize that significantly more patients will cho... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/16/2025
Locations: Rutgers School of Dental Medicine, Newark, New Jersey
Conditions: Pain Management, Shared Decision Making
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Remote Assessment of Digital Neurologic Testing
NCT07014982
Recruiting
The RADiaNT study investigates whether guided meditation, using the Muse™ headband and biofeedback app, can improve sleep, mood, and cognitive performance, aiming to assess its impact on mental and emotional well-being.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Neurology
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A Study of the Pharmacokinetic Interaction Between Pirfenidone, Nintedanib, and Nalbuphine Extended Release (NAL ER) in Healthy Participants
NCT07015398
Recruiting
The primary purpose of this study is to evaluate the effect of steady-state NAL ER on the pharmacokinetics (PK) of pirfenidone or nintedanib and the effect of steady-state pirfenidone or nintedanib on the PK of NAL ER in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/16/2025
Locations: Clinical Pharmacology of Miami, Miami, Florida
Conditions: Healthy Participants
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