A Study of [14C]-LY4065967 in Healthy Participants
NCT07039045
Recruiting
The purpose of this study is to investigate the absorption, metabolism, excretion, and bioavailability of LY4065967 in healthy male participants. This is a 2-part study. The study will last about 58 days for participants in Part 1 and about 60 days for participants in Part 2.
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
07/16/2025
Locations: Fortrea Clinical Research Unit, Madison, Wisconsin
Conditions: Healthy
Register for Updates
Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans
NCT07071077
Recruiting
The purpose of this study is to assess if storytelling is an effective approach for promoting lifestyle and behavioral change among individuals managing hypertension and to determine if storytelling interventions can help to reduce blood pressure and improve medication adherence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Delaware, Newark, Delaware
Conditions: Hypertension
Register for Updates
Walnuts as an Infant Solid Food for Health
NCT07081698
Recruiting
The objective is to investigate the effect of walnuts on gut microbiota, inflammatory markers, atopic dermatitis status, and indices of allergy outcomes in breastfed infants during early complementary feeding. The three primary aims include: Aim 1: Evaluate the effect of walnut consumption on gut microbiota structure and function, inflammation, atopic dermatitis, and allergy outcomes. Aim 2: Evaluate the impact of walnut consumption on infant growth trajectories and risk of overweight. Aim 3... Read More
Gender:
ALL
Ages:
Between 5 months and 5 months
Trial Updated:
07/16/2025
Locations: Food Science and Human Nutrition Clinical Research Laboratory, Fort Collins, Colorado
Conditions: Gut -Microbiota, Inflammatory Markers, Infant Development
Register for Updates
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
NCT07082543
Recruiting
An 18-month double-blind, randomized, placebo-controlled, multicenter, Phase 3 study to evaluate the safety and efficacy of oral nizubaglustat (AZ-3102) in late-infantile and juvenile forms of GM1 gangliosidosis or GM2 gangliosidosis
Gender:
ALL
Ages:
4 years and above
Trial Updated:
07/16/2025
Locations: Children's Hospital and Research Center at Oakland, Oakland, California +30 locations
Conditions: Gangliosidoses, GM2, Gangliosidosis, GM1
Register for Updates
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)
NCT07082725
Recruiting
An 18-month double-blind, randomized, placebo-controlled, multicenter, Phase 3 study to evaluate the safety and efficacy of oral nizubaglustat (AZ-3102) in late-infantile and juvenile forms of Niemann-Pick type C disease
Gender:
ALL
Ages:
4 years and above
Trial Updated:
07/16/2025
Locations: Children's Hospital and Research Center at Oakland, Oakland, California +26 locations
Conditions: Niemann-Pick Type C Disease
Register for Updates
A Study of TLN-121 in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas
NCT07082803
Recruiting
The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies in patients with relapsed or refractory Non-Hodgkin Lymphomas
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: The START Center for Cancer Care - Midwest, Grand Rapids, Michigan +1 locations
Conditions: Lymphoma, Lymphoma, Non Hodgkin
Register for Updates
A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age
NCT07082829
Recruiting
Characterize the safety, tolerability and pharmacokinetics of ORX142 following single and multiple doses.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/16/2025
Locations: Site #1, Lincoln, Nebraska
Conditions: Excessive Daytime Sleepiness
Register for Updates
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
NCT07083531
Recruiting
This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
07/16/2025
Locations: UConn Health, Farmington, Connecticut
Conditions: Sickle Cell Disease, Sickle Cell Trait
Register for Updates
Frame Support Study
NCT07083700
Recruiting
This is a randomized, controlled pilot study evaluating an intervention of non-significant risk. Potential subjects will be women who have completed an initial new patient consultation at one of the participating fertility clinics. Approximately 400 subjects will be enrolled from multiple fertility clinics.
Gender:
FEMALE
Ages:
Between 22 years and 44 years
Trial Updated:
07/16/2025
Locations: Inception Fertility Research Institute, Houston, Texas
Conditions: Fertility Issues, Emotional Stress
Register for Updates
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
NCT02418442
Recruiting
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +81 locations
Conditions: Rheumatic Joint Disease
Register for Updates
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
NCT02664831
Recruiting
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling me... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Maine Medical Center, Portland, Maine
Conditions: Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
Register for Updates
Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer
NCT03832361
Recruiting
The purpose of this study is to evaluate the activity and safety profile of mirvetuximab soravtansine (IMGN853) in patients with type II endometrial cancers that overexpress folate receptor alpha (FRα).
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
07/15/2025
Locations: Smilow Cancer Hospital at Yale New Haven, New Haven, Connecticut
Conditions: Endometrial Cancer
Register for Updates