Multi-Omics for Maternal Health After Preeclampsia
NCT06340152
Recruiting
To develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/02/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Pre-Eclampsia, Pregnancy Induced Hypertension
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Tislelizumab in People With Colorectal Cancer
NCT06529523
Recruiting
The researchers are doing this study to find out whether tislelizumab is an effective treatment for people with colorectal cancer who are living in Nigeria. The researchers will also look at the safety of the study drug. All participants in this study will be treatment naïve (they have not yet received treatment for their cancer), and their cancer will be mismatch repair deficient (dMMR). dMMR cancer can happen when your cells are unable to repair mistakes made during the cell division process. Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York +2 locations
Conditions: Colorectal Cancer
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Use of a Colorectal Cancer Screening Decision Support Tool in Primary Care
NCT06625983
Recruiting
The research question we pose is, Does a colorectal cancer (CRC) screening decision support tool offered in advance of primary care visits increase CRC screening completion rates? Our work aims to answer this question by evaluating the effectiveness of an MGB decision support tool to 1) promote informed decisions about CRC screening for average risk patients ages 45-75, 2) deploy a decision support tool as part of a primary care bundle questionnaire, and 3) support patients in completing their p... Read More
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
04/02/2025
Locations: Mass General Brigham, Boston, Massachusetts
Conditions: Colorectal Cancer Control and Prevention, Colorectal Cancer Screening, Shared Decision Making, Decision Aid
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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
NCT06703073
Recruiting
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress Syndrome (ARDS) utilizing a platform trial design. Participants will be randomized to receive either a placebo or one of the active treatments. This record describes the default procedures and analyses for all cohorts. Each specific cohort may have additional eligibility requi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: St. Luke's Boise Medical Center, Boise, Idaho +1 locations
Conditions: Acute Respiratory Distress Syndrome (ARDS), ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome
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Listener Training for Improved Intelligibility of People With Parkinson's Disease
NCT06815263
Recruiting
Listener training offers a promising avenue for improving communication for people with dysarthria due to Parkinson's disease by offsetting the intelligibility burden from the patient onto their primary communication partners. Here, we employ a repeated-measures, randomized controlled trial to establish the efficacy of listener training for patients with PD and their primary communication partners. This translational work will establish a new realm of clinical practice in which the intelligibili... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Florida State University, Tallahassee, Florida +1 locations
Conditions: Dysarthria, Hypokinetic
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Evaluating the Reach of Clinical Decision Support for Patients With Heart Failure
NCT06847906
Recruiting
To work best, clinical decision support tools (CDS) must be timed to provide support when healthcare decisions are made, which includes virtual visits (phone or video). Unfortunately, most CDS tools are either missing from virtual visits or not designed for the unique context of virtual visits (e.g., availability of physical assessments and labs, different workflows), which could generate new inequities for patients more likely to use virtual visits. The objective of this study is to test the re... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: UCHealth Primary Care and Cardiology Outpatient Clinics, Aurora, Colorado
Conditions: Decision Support Systems, Clinical, Heart Failure
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IBD Pregnancy Registry
NCT06910553
Recruiting
Data collected through the registry may be used to address a range of research questions and objectives, including but not limited to the following: Research question: Is there an increased risk of adverse maternal, fetal, or infant outcomes among individuals who are exposed to Inflammatory Bowel Disease (IBD) treatments during pregnancy? The primary objective of the registry is to estimate the prevalence of major congenital malformations among pregnant individuals with IBD who are exposed to... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/02/2025
Locations: PPD, Wilmington, North Carolina
Conditions: Inflammatory Bowel Disease (IBD)
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Short Term Genetic Effects of Chemotherapy on Male Germ Cells
NCT02975245
Recruiting
This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.
Gender:
MALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/02/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Cancer
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e-Connect: A Service System Intervention for Justice Youth at Risk for Suicide
NCT03586895
Recruiting
The investigators propose to create e-Connect, a new service delivery model that will enable real time identification and targeted, county-specific referral and linkage of participants with suicidal behavior (SB) and related behavioral health (BH) problems. e-Connect will: (i) establish and formalize interagency referral decisions based on clinical need, jointly derived by JJ (juvenile justice) and BH agencies; (ii) train probation staff to increase BH/SB understanding; (iii) utilize an existing... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
04/02/2025
Locations: Columbia University, New York, New York
Conditions: Suicide
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A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease
NCT04484272
Recruiting
Our long-term goal is to reduce stress and improve sickle cell disease (SCD) pain control with less opioid use through an intervention with self-management relaxation/distraction exercises (RDE), named You Cope, We Support (YCWS). Americans living with SCD suffer recurrent episodes of acute and chronic pain, both of which are exacerbated by stress. Building on the successes of our prior formative studies, we now propose a well-designed, appropriately powered study to test efficacy of YCWS on out... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/02/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Sickle Cell Disease
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Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV
NCT04795219
Recruiting
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated with fat accumulation that ranges from benign, non-progressive liver fat accumulation to severe liver injury, cirrhosis, and liver failure. NAFLD is the most common liver disease in US adults and the second leading cause for liver transplantation in the US. The natural history of NAFLD in the general population has been well described, with those with non-alcoholic fatty liver (NAFL, or simple steatosis) destin... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/02/2025
Locations: University of Alabama, Tuscaloosa, Alabama +7 locations
Conditions: NAFLD, NAFLD-HIV, Hiv
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JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
NCT04892173
Recruiting
This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy and safety of JNJ-90301900 (NBTXR3) / radiation therapy (RT)±cetuximab versus RT±cetuximab in treatment-naïve, platinum-ineligible, elderly participants with locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/02/2025
Locations: Memorial Radiation Oncology Medical Group Laguna Hills, Laguna Hills, California +158 locations
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma, Aged
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