Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
NCT06371404
Recruiting
The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurrent PTSD and AUD with control groups. While there are a large number of studies conducted in preclinical stress and addiction models, these findings have not been translated to people living with these... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/07/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Alcohol Use Disorder, Post Traumatic Stress Disorder
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The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
NCT06377852
Recruiting
The purpose of this study is to generate evidence on an alternative dosing strategy for CDK4/6 inhibitors to help more patients with Metastatic Breast Cancer (MBC) (age ≥ 65 years) tolerate side effects and stay on treatment longer, to derive the most clinical benefit from these drugs. The primary objective of the CDK Study is to compare time to treatment discontinuation (TTD) on the approved dosing for palbociclib (125 mg orally daily on days 1-21 of 28-day cycle) or ribociclib (600 mg orally... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/07/2025
Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +62 locations
Conditions: Metastatic Breast Cancer
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Implementing the Spotlight AQ Platform in Adolescent/ Young Adult (16-25 Years Old) Type 1 Diabetics (T1D)
NCT06390371
Recruiting
The goal of this clinical trial is to compare the Spotlight AQ survey platform to the standard of care (SOC) pre-clinic assessment in adolescents \& young adults (16-25 years old) with Type 1 Diabetes (T1D). The main questions it aims to answer are: * Does using the Spotlight AQ survey in clinic decrease the A1c in the people who use it? * Do patients and healthcare providers like using the spotlight AQ survey? Participants will use the Spotlight AQ survey before coming in to two standard of... Read More
Gender:
ALL
Ages:
Between 16 years and 25 years
Trial Updated:
07/07/2025
Locations: Children's Mercy, Kansas City, Missouri
Conditions: Type 1 Diabetes Mellitus
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Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
NCT06392711
Recruiting
The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands. The main question it aims to answer is whether injection of MSCs into salivary glands results in any improvement in dry mouth. Participants will: * have bone marrow collected using a needle * undergo a salivary gland ultrasound * complete questionnaires * receive an injection of the bone marrow cells into a s... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/07/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Xerostomia, Graft-versus-host-disease, Sjogren's Disease
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A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
NCT06423365
Recruiting
The goal of this clinical trial is to learn if an educational website can help patients make an informed decision and engage in shared decision-making with their healthcare provider regarding cholesterol lowering medication use after they have stopped statin therapy due to self-reported muscle symptoms from taking a statin medication. The main questions the trial aims to answer are: 1. Compared to usual care, are patients who engage with the website after experiencing statin-associated muscle s... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
07/07/2025
Locations: Kaiser Permanente Colorado, Aurora, Colorado
Conditions: Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Cardiovascular Diseases, Pharmacists, Placebo Effect
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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NCT06423430
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
07/07/2025
Locations: University of Alabama at Birmingham - Dept. of Psychiatry, Birmingham, Alabama +21 locations
Conditions: Treatment Resistant Depression
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The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
NCT06476795
Recruiting
Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease. Dietary flavanols can be obtained from the intake of foods such as tea, cocoa, wine, berries and apples. Incorporating Chardonnay Marc (the skins and seeds of Chardonnay grapes) into the diet can be an additional source of dietary flavanols. Like other flavanol-rich foods, Chardonnay Marc provides fiber and polysaccharides that may benefit gut health. This study see... Read More
Gender:
FEMALE
Ages:
Between 45 years and 70 years
Trial Updated:
07/07/2025
Locations: University of California, Davis, Davis, California
Conditions: Cardiovascular Diseases, Adiposity, Cardiometabolic Syndrome
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Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes
NCT06478186
Recruiting
A Phase 2 Randomized Study to Evaluate the Effects of triamcinolone acetonide extended-release (TA-ER; Zilretta) vs. triamcinolone acetonide immediate-release (TA-IR; Kenalog) on Blood Glucose Levels in Diabetic Subjects with Knee Osteoarthritis. Subjects should have Type 2 Diabetes Mellitus (T2DM) with HbA1C ≤9 that is managed without insulin and have been diagnosed with symptomatic unilateral or bilateral osteoarthritis (OA) of the knee, based on clinical and radiological criteria (if bilatera... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/07/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Osteoarthritis, Knee, Diabetes Mellitus, Type 2
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Study With [225Ac]Ac-FL-020 in mCRPC Participants
NCT06492122
Recruiting
The purpose of this study is to evaluate the safety, therapeutic effect, and pharmacokinetics of \[225Ac\]Ac-FL-020 in participants with metastatic castration-resistant prostate cancer (mCRPC).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: City of Hope Medical Center, Duarte, California +4 locations
Conditions: Metastatic Castration-resistant Prostate Cancer
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How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care.
NCT06495021
Recruiting
This study is to see Osteopathic Manipulative Therapy, or OMT, can aid in treating patients being seen for respiratory illness and associated symptoms. The hypothesis is that the addition of OMT therapy, alongside other standard care (such as a medication), can help lessen patient symptoms sooner than just other treatment alone, and the duration of the condition will shorten as well.
Gender:
ALL
Ages:
Between 65 years and 100 years
Trial Updated:
07/07/2025
Locations: Geisinger 65-Forward, Buckhorn, Bloomsburg, Pennsylvania
Conditions: Pneumonia, Sinusitis, Bronchitis, Respiratory Disease, Respiratory Tract Infections
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The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
NCT06520345
Recruiting
The purpose of this study is to evaluate the efficacy and safety of 177Lu-TLX591 in patients with metastatic castration-resistant prostate cancer who have progressed following treatment with Androgen Receptor Pathway Inhibitor Treatment
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: Chao Family Comprehensive Cancer Centre, Orange, California +14 locations
Conditions: Metastatic Castration-resistant Prostate Cancer
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Study of NMS-03597812 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia
NCT06549790
Recruiting
The aim of PERKA-812-003 study is to investigate the safety, pharmacokinetics and preliminary anti-tumor activity of treatment with NMS-03597812 as single agent in Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) patients who have exhausted standard treatment, including a subset of patients with TP53 mutations. It is anticipated that combination with venetoclax will be further evaluated following a future protocol amendment, once the Recommended Range Dose (RDR) as single agent has been defi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: City of Hope - Duarte, Duarte, California +6 locations
Conditions: Relapsed/Refractory Acute Myeloid Leukemia
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