Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
NCT05596760
Recruiting
The goal of this clinical trial is to improve communication among clinicians, patients with memory problems, and their family members. We are testing a way to help clinicians have better conversations to address patients' goals for their healthcare. To do this, we created a simple, short guide called the "Jumpstart Guide." The goal of this research study is to show that using this kind of guide is possible and can be helpful for patients and their families. Patients' clinicians may receive a Jum... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Harborview Medical Center, Seattle, Washington +2 locations
Conditions: Dementia, Chronic Disease, Palliative Care, Patient Care, Health Care Quality, Access, and Evaluation, Patient Care, Health Communication, Patient Care Planning, Quality of Life, Dementia, Vascular, Mixed Dementias, Alzheimer Disease, Huntington Disease, Lewy Body Disease, Creutzfeldt-Jakob Syndrome, Frontotemporal Lobar Degeneration, Cognitive Dysfunction, Cognitive Aging
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Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma
NCT05625594
Recruiting
This phase I trial tests the safety, side effects, and best dose of intracerebroventricularly (ICV) administered CD19-chimeric antigen receptor (CAR) T cells in treating patients with central nervous system (CNS) lymphoma. CAR T cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient's blood. Then the gene for a special receptor that binds to a certain protein,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Central Nervous System Lymphoma
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Electrical Stimulation for the Treatment of Optic Neuropathies
NCT05626426
Recruiting
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Byers Eye Institute, Palo Alto, California
Conditions: Glaucoma, Glaucoma, Open-Angle, Optic Nerve Diseases
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The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
NCT05652088
Recruiting
The objective of this study is to understand the effects of HIV cure strategies on the virus and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies with the potential for HIV cure will undergo a colonoscopy to obtain gastrointestinal tissue for research assays. This study will test whether receiving these therapies will induce changes in the immune cells in the gastrointestinal tract and reduce the tissue-associated HIV viral levels.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/02/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: HIV Infection
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Cardiac Power Output in Cardiogenic Shock Patients
NCT05700617
Recruiting
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: The University of Chicago, Chicago, Illinois
Conditions: Heart Failure, Cardiogenic Shock
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Long Term Followup of Patients Enrolled in MC1137, BEAUTY Study
NCT05703399
Recruiting
This study gathers information and samples for further analysis as part of the BEAUTY study. The purpose of the BEAUTY study was to better understand the reasons why or why not breast cancers respond to standard chemotherapy. Collecting samples of blood and tissue and health and treatment information from patients on the BEAUTY study may help doctors identify changes that make cancer better respond to standard chemotherapy and develop better therapies for the treatment of cancer.
Gender:
ALL
Ages:
All
Trial Updated:
07/02/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Breast Carcinoma
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Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
NCT05775159
Recruiting
GEMINI-Hepatobiliary study will assess the efficacy, safety and tolerability of novel immunomodulators alone and in combination with other anticancer drugs in participants with specified advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Research Site, Birmingham, Alabama +60 locations
Conditions: Hepatocellular Carcinoma, Biliary Tract Cancer
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SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
NCT05812755
Recruiting
The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and markers of kidney and brain injury in patients having heart surgery. The main questions it aims to answer are: 1. Does soluble guanylyl cyclase stimulation improve blood vessel function compared to placebo? 2. Does soluble guanylyl cyclase stimulation decrease markers of kidney injury and brain injury compared to placebo? Participants wil... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Endothelial Dysfunction, Vascular Diseases, Kidney Injury, Brain Disease, Vascular Inflammation
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MADRE (Mammograms Available Due to Research and Education)
NCT05841355
Recruiting
The design builds on past studies by integrating social network analysis (SNA) and implementation science (IS) into a longitudinal randomized clinical trial (RCT). The investigator will compare the long-term effects of interventions by examining guideline-concordant initial and repeat Breast Cancer (BC) screening.
Gender:
FEMALE
Ages:
Between 40 years and 74 years
Trial Updated:
07/02/2025
Locations: Mile Square Health Center, Chicago, Illinois +1 locations
Conditions: Breast Cancer Screening
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Novel Mental Health Therapies to Improve Military Readiness
NCT05887713
Recruiting
To evaluate the efficacy of CES as a therapy to treat and mitigate symptoms of generalized anxiety in DoD beneficiaries in a prospective clinical trial and compare this to sham (placebo) CES.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada
Conditions: Anxiety, Alpha Stim, Cranial Electrotherapy Stimulation, Cognitive Behavioral Therapy, Heart Rate Variability
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The Brain Processes Underlying Speech Motor Learning and Speech Production
NCT05918679
Recruiting
The aim of this research is to develop protocols that selectively target and improve speech-motor learning processes. Participants will be asked to name pictures, read words/sentences, and listen to sounds while their speech signals will be collected during the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Healthy Adults
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Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
NCT05977179
Recruiting
The primary objective of this study is to conduct a 16-week randomized controlled trial aimed at investigating the effectiveness of the Whole-Diet Approach when following a healthy US-style diet rich in anti-inflammatory properties. The study will focus on evaluating its impact on reducing symptoms related to Post-Acute Sequelae of SARS-CoV-2 Infection (PACS) in adults aged 50 years and older. The main research questions this study aims to answer are: 1. Does adhering to a healthy US-style die... Read More
Gender:
ALL
Ages:
Between 50 years and 94 years
Trial Updated:
07/02/2025
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Post-Acute COVID-19 Syndrome, Fatigue
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