A Study of an Alternative Treatment Approach (Preoperative Radiotherapy, Then Mastectomy, Then Immediate Reconstruction Surgery) in People With T4 Breast Cancer
NCT05412225
Recruiting
The purpose of this study to test an alternative treatment approach that involves giving participants radiotherapy before their mastectomy (preoperative radiotherapy) and performing immediate reconstruction surgery at the time of mastectomy. The immediate reconstruction surgery is called an immediate autologous reconstruction (IR) and is different than the standard reconstruction surgery people with T4 breast cancer have. IR is a surgical procedure where immediately following your mastectomy, th... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Breast Cancer, Invasive Breast Cancer
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CIMR Neuromuscular Research Biobank
NCT05434572
Recruiting
The purpose of this research repository is to collect, store, and share with other researchers any tissues that subjects with all types of neuromuscular disease are willing to donate. These samples will be stored at Virginia Commonwealth University (VCU) and will be used for future research with this population.
Gender:
ALL
Ages:
75 years and below
Trial Updated:
07/01/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuromuscular Diseases, Neuromuscular Disorder, Neuromuscular Diseases in Children
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Rehab CARES In USA: Clinical Trial
NCT05542121
Recruiting
In Phase 2, Patients in a community-based setting who have had a stroke will be evaluated by rehabilitation professionals and asked to perform a battery of clinical assessments before and after standard of care and robot assisted therapy with Rehab CARES system of simple force-feedback robots that are adapted to deliver single and group therapy.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/01/2025
Locations: Mercy Living Independently for Elders (L.I.F.E) - West Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Stroke, Hemiplegia
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Hydrogen's Feasibility and Safety as a Therapy in ECPR
NCT05574296
Recruiting
The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/01/2025
Locations: Children's National Hospital, Washington, District of Columbia +3 locations
Conditions: Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
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Healthy for Two-Home Visiting (H42-HV): Health Coaching for Pregnant Women
NCT05619705
Recruiting
The purpose of this study is to compare the effectiveness of H42-HV integrated into home visiting compared with usual home visiting services in reducing postpartum weight retention (difference between pre-pregnancy weight and weight at 6 months postpartum) among pregnant and postpartum participants. The overall goal is to improve long-term cardiometabolic health.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
Conditions: Postpartum Weight Retention, Pregnancy Weight Gain, Overweight and Obesity, Behavior, Health
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REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)
NCT05632809
Recruiting
To learn about the effects of the investigational drug NKTR-255 in combination with the standard drug durvalumab on locally advanced NSCLC when given after CRT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Lung Cancer
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Metastatic Leiomyosarcoma Biomarker Protocol
NCT05653388
Recruiting
Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs in approximately 50% of patients diagnosed with leiomyosarcoma and prognosis is poor in setting of metastatic disease. A minority of patients benefit from treatment with chemotherapy and early biomarkers of benefit from treatment are lacking. A biomarker of tumor response and patient survival benefit... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/01/2025
Locations: Sarcoma Oncology Research Center, Santa Monica, California +9 locations
Conditions: Leiomyosarcoma
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Autonomic Effects of Stimulation in SCI
NCT05664646
Recruiting
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: James J. Peters VA Medical Center, Bronx, NY, Bronx, New York
Conditions: Spinal Cord Injury
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Using a Telehealth and Shared Decision-Making Model to Address Preventative Medicine Strategies Among Communities in Louisiana
NCT05676970
Recruiting
This study is a 12-18 month behavioral intervention study to assess the impact of enrolling individuals a clinical pharmacist run Telehealth education focused on wellness and preventive health strategies. Individuals will be randomized to either a wellness education only model focusing on nutrition, diabetes, hyperlipidemia and hypertension or a wellness education model with personalized preventative medicine strategies for the patient. All participants will complete individual and group based i... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/01/2025
Locations: Xavier University of Louisiana, New Orleans, Louisiana
Conditions: Preventative Medicine
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D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients
NCT05734560
Recruiting
The purpose of this research study is to determine the safety and efficacy of administering a single intracerebral (within the brain) dose of investigational compounds called D2C7-immunotoxin (IT) and 2141-V11 in residual disease (within tumor margins) after surgery, followed by later repeated injections of 2141-V11 in the subcutaneous area (under the skin) around the lymph nodes of the head and neck for adults newly diagnosed with a type of cancerous brain tumor called glioblastoma. The word "i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Newly Diagnosed MGMT Unmethylated Glioblastoma
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Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
NCT05773144
Recruiting
To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Kaiser Permanente Northern California, Oakland, California +2 locations
Conditions: Colonic Neoplasms
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A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951
Recruiting
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy) and standard adjuvant endocrine therapy (ET) for at least 2 years and up to 5 years. The planned duration of treatment in either arm of the study is 60 months.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
07/01/2025
Locations: Research Site, Birmingham, Alabama +723 locations
Conditions: Breast Cancer, Early Breast Cancer
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