A Study to Evaluate the Effect of Food or no Food on the Bioavailability of an Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult Subjects
NCT07043634
Recruiting
This study will examine comparative bioavailability of single dose of a fixed dose combination (FDC) of extended release Torsemide and Spironolactone given with or without food in healthy adult subjects.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
06/27/2025
Locations: Sarfez Pharmaceuticals, Vienna, Virginia
Conditions: Bioavailability Heathy Volunteers
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Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)
NCT07046585
Recruiting
The FIND-CRC study is a prospective collection of samples and data from participants who are at average risk of developing colorectal cancer (CRC). Collected samples and data will be analyzed to evaluate the clinical performance of the Natera CRC Screening Test.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/27/2025
Locations: Natera, Inc, Austin, Texas +1 locations
Conditions: Colo-rectal Cancer
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The Airports, Air Quality, and Asthma (AAA) Study
NCT07047430
Recruiting
For children with asthma, exposure to indoor air pollution increases the risk of a serious asthma exacerbation, which can be life-threatening. Interventions aimed at improving indoor air quality, including use of a portable air cleaner with a high-efficiency particulate air (HEPA) filter, can reduce this risk, but the effectiveness, feasibility and acceptability of HEPA air cleaners varies by setting. In collaboration with a community health worker (CHW) delivered asthma education program, the i... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
06/27/2025
Locations: University of Washington, Seattle, Washington
Conditions: Pediatric Asthma
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FRESH-EATS Project
NCT07053644
Recruiting
The goal of this randomized controlled trial is to determine the feasibility of the FRESH-EATS project in children ages 8-12 and their parents/caregivers residing in low-income, predominantly minority neighborhoods. The main questions it aims to answer are: Is the FRESH-EATS intervention feasible to implement and well-received by parent-child dyads? Does the FRESH-EATS multilevel multicomponent intervention improve dietary behaviors of children and their parents/caregivers compared to the compa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: University of South Florida, Tampa, Florida
Conditions: Dietary Behaviors, Obesity and Overweight
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Continuous Glucose Monitoring, Diabetes Education, and Peer Support for Management of Uncontrolled Type 2 Diabetes
NCT07054125
Recruiting
This research study is investigating whether a diabetes virtual group visit program using a continuous glucose monitor (CGM) can help improve glucose levels and quality of life in individuals with uncontrolled type 2 diabetes. People in the study will join group visits virtually to discuss using CGM, understanding CGM, and other information about ways to bring blood sugars to your goal (nutrition, movement, reducing stress, and techniques to start a new habit).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Whole Endo, Asheville, North Carolina
Conditions: Type 2 Diabetes Mellitus - Poor Control
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I-CARE Rural Pilot: Remote Digital Intervention for Rural-Dwelling Dementia Caregivers
NCT07054385
Recruiting
The purpose of this study is to assess feasibility and to estimate efficacy of our app "Brain CareNotes" for dementia caregivers who reside in a rural setting (as defined by RUCA codes 4 through 10). The Brain CareNotes app is designed to reduce informal caregiver burden of those caring for individuals with Alzheimer's disease and related dementias (ADRD) and behavioral and psychological symptoms of dementia (BPSD) of individuals with ADRD. The study will enroll up to 60 rural caregivers of comm... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Indiana University Bloomington, Bloomington, Indiana
Conditions: Caregiver Burden, Alzheimer&Amp;#39;s Disease
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Rural Autistic Individuals - Supporting Expression
NCT07054866
Recruiting
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are especially disadvantaged by the lack of accessible services in their rural communities. Individuals with other cognitive profiles, including Developmental Language Disorder (DLD), ADHD, Dyslexia, and others are welcome too. The study uses methods of eye tracking and recor... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
06/27/2025
Locations: Montana State University, Bozeman, Montana
Conditions: Autism Disorder, Language Development Disorders, ADHD, Typical Development, Rural Health, Children, Neuroimaging, Eye Tracking, EEG, fNIRS
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Evaluate the Efficacy and Safety of NT-0796 in Participants With Obesity With or Without Type 2 Diabetes Mellitus
NCT07055516
Recruiting
A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NT-0796 as an Adjunct to a Reduced Calorie Diet and Increased Physical Activity in Obese Participants With/Without Type 2 Diabetes over a 6 months treatment period.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/27/2025
Locations: Investigative site, Mesa, Arizona +8 locations
Conditions: Obesity and Type 2 Diabetes
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Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
NCT00071045
Recruiting
This study will collect biological samples for use in research experiments aimed at better understanding the clinical features of certain diseases. The specimens may be used to evaluate the effectiveness of known therapies, refine treatment approaches, identify potential new therapies, and explore opportunities for disease prevention. The following individuals 2 years of age or older may be eligible for this study: * Patients with a cancerous solid tumor or a cancerous or non-cancerous blood d... Read More
Gender:
ALL
Ages:
Between 2 years and 100 years
Trial Updated:
06/26/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Neoplasms, Hematologic Neoplasms, Healthy Volunteers
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A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
NCT03165734
Recruiting
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thromb... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center, Birmingham, Alabama +206 locations
Conditions: Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
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Non-invasive Nerve Stimulation for PTSD and Sleep
NCT03170440
Recruiting
In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/26/2025
Locations: UF Health Jacksonville, Gainesville, Florida +2 locations
Conditions: Post Traumatic Stress Disorder, Traumatic Brain Injury
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Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
NCT03581318
Recruiting
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs. Researchers want to find better MRI methods and new ways of imaging cardiovascular disease and better understand normal and abnormal cardiovascular and brain function. Researchers are also interested in seeing if gadolinium, the commonly used MRI contrast agent, stays in the body lo... Read More
Gender:
ALL
Ages:
Between 7 years and 100 years
Trial Updated:
06/26/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal and Abnormal Cardiovascular Physiology
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