Clinical Evaluation of No Needle Dental Anesthesia Compared to Syringe Anesthesia Delivery
NCT06874244
Recruiting
The purpose of the study is to evaluate two different ways to administer the numbing solution. One is with a conventional needle and syringe the other method iontophoresis is a machine that supplies a weak current through electrodes that touch your teeth. Both methods use an anesthesia solution to make your teeth numb but the iontophoresis system contains no needle and the delivery device does not penetrate the gum.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: LSUHSC School of Dentistry, New Orleans, Louisiana
Conditions: Local Anesthesia Injection Pain
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Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
NCT03206060
Recruiting
Background: Pheochromocytoma and paraganglioma are rare tumors. They usually form inside and near the adrenal gland or in the neck region. Not all these tumors can be removed with surgery, and there are no good treatments if the disease has spread. Researchers think a new drug may be able to help. Objective: To learn the safety and tolerability of Lu-177-DOTATATE. Also, to see if it improves the length of time it takes for the cancer to return. Eligibility: Adults who have an inoperable tum... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/07/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pheochromocytoma, Paraganglioma, Neuroendocrine Tumors, Neuroendocrine Neoplasms
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Synergistic Activity of Human Milk Nutrients and Infant Cognition
NCT03838536
Recruiting
Purpose: To establish a whole food, egg, as a viable study material to supplement mothers and infants with nutrients that support optimal brain development. There will be 84 breastfeeding dyads, 3 months postnatal. Mothers will be randomized to a whole egg or egg white (due to lack of an appropriate control food). Initial diet intake will be screened using the NDSR. Participants will come to the lab 3 times across 3 months (age 3 months, 4.5 months, and 6 months). Milk, saliva, and plasma will... Read More
Gender:
ALL
Ages:
Between 3 months and 35 years
Trial Updated:
03/07/2025
Locations: Nutrition Research Institute, Kannapolis, North Carolina
Conditions: Breastfeeding, Exclusive
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The HPV 9-10 Trial: Early Initiation of HPV Vaccination
NCT04722822
Recruiting
Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not have their children vaccinated when it is recommended at age 11 or 12. In this study, we will examine in a randomized trial whether earlier initiation of the vaccine at age 9-10 years will result in less parental refusal and higher rates of full vaccination at younger ages, before early sexua... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California at Los Angeles, Los Angeles, California +1 locations
Conditions: HPV
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A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and Adults
NCT05164094
Recruiting
The main objective of Part A of this trial is to evaluate the safety and reactogenicity of mRNA-1189 in 18- to 30-year-old healthy adults, the main objective of Part B is to evaluate the safety and reactogenicity of mRNA-1189 in 12- to \<18-year-old healthy EBV-seronegative adolescents, and the main objective of Part C is to evaluate the safety and reactogenicity of mRNA-1189 in 10- to 21-year-old healthy adolescents and adults.
Gender:
ALL
Ages:
Between 10 years and 30 years
Trial Updated:
03/07/2025
Locations: Medical Affiliated Research Institute, Huntsville, Alabama +66 locations
Conditions: Epstein-Barr Virus Infection
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A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age
NCT05436834
Recruiting
This study will evaluate the safety and immunogenicity of the mRNA-1273.214 vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concerns (VOCs) in participants aged 6 months to \<6 years, when administered as a primary series in SARS-CoV-2 vaccine-naïve participants (Part 1) and a single booster dose (BD) given to participants who previously received 2 doses of the mRNA-1273 vaccine as a primary series (Part 2); and will evaluate the safety and immunogenicity of t... Read More
Gender:
ALL
Ages:
Between 6 months and 5 years
Trial Updated:
03/07/2025
Locations: Trinity Clinical Research, LLC, Bessemer, Alabama +73 locations
Conditions: SARS-CoV-2
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3D Printed Breast Models in the Surgical Management of Breast Cancer
NCT05755984
Recruiting
To learn if providing a 3-D printed model of the breast can help breast cancer patients make decisions related to their care. During this study, some study participants will receive the 3-D printed model and some study participants will receive traditional breast imaging scans to learn if the 3-D printed model
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer
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CirrhosisRx CDS System
NCT05967273
Recruiting
The aim of the study is to compare the effect of CirrhosisRx, a novel clinical decision support (CDS) system for inpatient cirrhosis care, versus "usual care" on adherence to national quality measures and clinical outcomes for hospitalized patients with cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California San Francisco Medical Center, San Francisco, California
Conditions: Cirrhosis, Decision Support Systems, Clinical
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Alcohol After Bariatric Surgery 2
NCT06257771
Recruiting
The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are: * Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy?... Read More
Gender:
ALL
Ages:
Between 21 years and 64 years
Trial Updated:
03/07/2025
Locations: University of Illinois at Urbana Champaign, Urbana, Illinois
Conditions: Sleeve Gastrectomy
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Expansion of the T1DES Pilot to a Public Hospital
NCT06494722
Recruiting
Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-30 years with type 1 diabetes (T1D). In order to combat this issue, this study assesses the feasibility of the culturally tailored intervention T1DES and evaluates the effect of the T1DES intervention on diabetes outcomes in a pilot randomized clinical trial among Black young adults with T1D.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
03/07/2025
Locations: Grady Health System, Atlanta, Georgia
Conditions: Type 1 Diabetes
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Progesterone in Gender Affirming Hormone Therapy Study
NCT06807580
Recruiting
This study aims to study the effects of Oral Progesterone in Transgender Women. The primary goal is to study the effect of progesterone on psychological distress and secondarily on sleep quality, breast size, quality of life and gender congruence and cardiovascular risk.
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
03/07/2025
Locations: Emory Transgender Clinic, Atlanta, Georgia
Conditions: Transgender Women
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Voiceitt for People With Impairments in Speech
NCT06874322
Recruiting
The primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the Voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (CP), stroke, Amyotrophic Lateral Sclerosis (ALS), or Parkinson's disease.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
03/07/2025
Locations: Center for Assistive Technology, Pittsburgh, Pennsylvania
Conditions: Speech Impairment, Speech Disorder
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